2014
DOI: 10.1364/boe.5.001980
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Noncontact quantitative biomechanical characterization of cardiac muscle using shear wave imaging optical coherence tomography

Abstract: Abstract:We report on a quantitative optical elastographic method based on shear wave imaging optical coherence tomography (SWI-OCT) for biomechanical characterization of cardiac muscle through noncontact elasticity measurement. The SWI-OCT system employs a focused air-puff device for localized loading of the cardiac muscle and utilizes phasesensitive OCT to monitor the induced tissue deformation. Phase information from the optical interferometry is used to reconstruct 2-D depth-resolved shear wave propagation… Show more

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Cited by 93 publications
(70 citation statements)
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“…The time t for the wave to propagate from a reference measurement position to each location was obtained by cross-correlation analysis. The elastic wave velocity, c, was then obtained by the inverse slope of the linear fit of the propagation distances, Δd, to the elastic wave propagation delays, Δt [42]. Since the tissue-mimicking agar phantoms can be treated as an isotropic homogeneous elastic material, the Young's modulus [43], E, was estimated by [23,40,44]:…”
Section: J Of Biomedical Photonics and Eng 1(4)mentioning
confidence: 99%
“…The time t for the wave to propagate from a reference measurement position to each location was obtained by cross-correlation analysis. The elastic wave velocity, c, was then obtained by the inverse slope of the linear fit of the propagation distances, Δd, to the elastic wave propagation delays, Δt [42]. Since the tissue-mimicking agar phantoms can be treated as an isotropic homogeneous elastic material, the Young's modulus [43], E, was estimated by [23,40,44]:…”
Section: J Of Biomedical Photonics and Eng 1(4)mentioning
confidence: 99%
“…Point dynamic loading is attractive as a source of shear waves, and an attractive noncontact localized method is the micro-air puff developed and applied extensively by the Larin group [45, 57, 63, 81, [97][98][99][100][101][102][103][104][105][106][107][108][109][110][111][112][113][114][115][116], mainly to the cornea, but also to skin [108,116], cardiac and skeletal muscles [104], cartilage [101,106], fat and soft tissue tumors [97], and kidneys [112]. Similar to ARF-based excitation, an air puff can deliver a localized and well-controlled impulse stimulus, which can be accompanied by measurement of the tissue displacement or measurement of the air puff-induced elastic wave.…”
Section: Loading Methodsmentioning
confidence: 99%
“…The elastic wave velocity can be calculated from the ratio of the propagation distance to the time delay, which is usually obtained through the cross-correlation of the OCE-measured local axial displacement profiles along the wave propagation path (see Fig. 8(g)) [104,180]. As indicated by Eq.…”
Section: Surface Elastic Wave Methods and Applicationsmentioning
confidence: 99%
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“…Benefiting from the micrometer spatial resolution and millimeter penetration of optical coherence tomography (OCT), optical coherence elastography (OCE) based on the shear wave measurement has shown promising results in biomedical studies, including blood coagulation assessment, 8 ocular elasticity assessment, 4,9 and cardiac muscle measurement. 10 In an OCE application, an excitation from a force source, such as an ultrasonic transducer, 11-15 an airpuff device, 9 and a piezo-transducer (PZT), 16 is commonly applied to induce vibration, and OCT is used to detect the displacement and visualize the shear wave. Using shear wave elastography, the shear modulus is quantified by tracking the shear wave propagation.…”
mentioning
confidence: 99%