Noncontact photoacoustic imaging achieved by using a low-coherence interferometer as the acoustic detector

Wang, Yi; Li, Chunhui; Wang, Ke

doi:10.1364/ol.36.003975

Cited by 101 publications

(94 citation statements)

References 20 publications

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“…A fiber-optical interferometry based sensor may be more robust for acoustic detection in magnetothermoacoustics. 37 The theoretical modeling of the experimentally measured heating characteristics has been performed based on the simplest monodispersive model. A polydispersive model will certainly improve the estimation accuracy, if the core-sizedistribution of the SPION can be precisely measured.…”

Section: Discussionmentioning

confidence: 99%

Magnetothermoacoustics from magnetic nanoparticles by short bursting or frequency chirped alternating magnetic field: A theoretical feasibility analysis

et al. 2013

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Purpose:To propose an alternative method of thermoacoustic wave generation based on heating of magnetic nanoparticles (MNPs) using alternating magnetic field (AMF). Methods: The feasibility of thermoacoustic wave generation from MNPs by applying a short-burst of AMF or a frequency-modulated AMF is theoretically analyzed. As the relaxation of MNPs is strongly dependent upon the amplitude and frequency of AMF, either an amplitude modulated, fixed frequency AMF (termed time-domain AMF) or a frequency modulated, constant amplitude AMF (termed frequency-domain AMF) will result in time-varying heat dissipation from MNPs, which has the potential to generate thermoacoustic waves. Following Rosensweig's model of specific power loss of MNPs in a steady-state AMF, the time-resolved heat dissipations of MNPs of superparamagnetic size when exposed to a short bursting of AMF and/or to a linearly frequency chirped AMF are derived, and the resulted acoustic propagation is presented. Based on experimentally measured temperaturerise characteristics of a superparamagnetic iron-oxide nanoparticle (SPION) matrix in a steady-state AMF of various frequencies, the heat dissipations of the SPION under time-domain and frequencydomain AMF configurations that could have practical utility for thermoacoustic wave generation are estimated. Results:The initial rates of the temperature-rise of the SPION matrix were measured at an ironweight concentration of 0.8 mg/ml and an AMF frequency of 88.8 kHz to 1.105 MHz. The measured initial rates of temperature-rise were modeled by Rosensweig's theory, and projected to 10 MHz AMF frequency, at which a 1 μs bursting corresponding to a 1.55 mm axial resolution of acoustic detection could contain 10 complete cycles of AMF oscillation and the power dissipation is approximately 84 times of that at 1 MHz. Exposing the SPION matrix to a 1 μs bursting of AMF at 10 MHz frequency and 100 Oe field intensity would produce a volumetric heat dissipation of 7.7 μJ/cm 3 over the microsecond duration of the AMF burst. If the SPION matrix is exposed to a 1 ms long AMF train at 100 Oe field intensity that chirps linearly from 1 to 10 MHz, the volumetric heat dissipation produced over each 2π phase change of the AMF oscillation is estimated to increase from 0.15 to 1.1 μJ/cm 3 within the millisecond duration of the chirping of AMF. Conclusions: The heat dissipations upon SPION (∼1 mg/ml iron-weight concentration) by a 1 μs bursting of 100 Oe AMF at 10 MHz and a 1 ms train of 100 Oe AMF that chirps linearly from 1 to 10 MHz were estimated to determine the potential of thermal-acoustic wave generation. Although thermoacoustic wave generation from MNPs by time-or frequency-domain AMF applications is predicted, the experimental generation of such a wave remains challenging. © 2013 American Association of Physicists in Medicine. [http://dx

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Section: Discussionmentioning

confidence: 99%

Magnetothermoacoustics from magnetic nanoparticles by short bursting or frequency chirped alternating magnetic field: A theoretical feasibility analysis

et al. 2013

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“…[39][40][41] In order to achieve the noncontact detection of ultrasonic signals, Wang Yi et al employed the low coherence Michelson interferometer (the detection bandwidth up to 17 MHz) achieving noncontact PA signal detection. 28 In 2012, Cedric Blatter adopted phasesensitive optical coherence tomography system to realize the noncontact measurements of PA signals (the bandwidth of 13 MHz), and acquired PA and OCT images of simulated samples. 42 In the same year, Monchalin et al utilized the confocal FP interferometer (the axial resolution 20 m, the lateral resolution 50-100 m) for the detection of PA signal and have successfully realized the PA and ultrasonic imaging of biological tissue.…”

Section: All-optical Pa Detectionmentioning

confidence: 99%

“…[28][29][30][31] The probe is divided into two beams through a beam splitter, one beam is focused through a lens onto a mirror, the other beam is focused on the surface of the sample by a dichroic mirror and an objective lens, and the light is emitted from the sample arm and re°ected by the reference arm. Beam is coherent light through the photodetector to receive coherent signal, which formed the Michelson interferometer.…”

Section: All-optical Pa Detectionmentioning

confidence: 99%

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All-optically integrated photoacoustic and optical coherence tomography: A review

Qiao

Chen

2017

J. Innov. Opt. Health Sci.

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All-optically integrated photoacoustic (PA) and optical coherence tomography (OCT) dualmode imaging technology that could o®er comprehensive pathological information for accurate diagnosis in clinic has gradually become a promising imaging technology in the aspect of biomedical imaging during the recent years. This review refers to the technology aspects of alloptical PA detection and system evolution of optically integrated PA and OCT, including Michelson interferometer dual-mode imaging system, Fabry-Perot (FP) interferometer dualmode imaging system and Mach-Zehnder interferometer dual-mode imaging system. It is believed that the optically integrated PA and OCT has great potential applications in biomedical imaging.

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“…Thus, no extra PAM display is required, which can significantly enhance clinical translation. In the future, three issues needs to be addressed: (1) noncontact detection of photoacoustic signals to remove water or ultrasound gel coupling, 21 (2) improvement of the image display rate using graphics processing unit, 22 and ( …”

mentioning

confidence: 99%

In vivo virtual intraoperative surgical photoacoustic microscopy

Han

Lee

Kim

et al. 2013

Applied Physics Letters

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We developed a virtual intraoperative surgical photoacoustic microscopy system by combining with a commercial surgical microscope and photoacoustic microscope (PAM). By sharing the common optical path in the microscope and PAM system, we could acquire the PAM and microscope images simultaneously. Moreover, by employing a beam projector to back-project 2D PAM images onto the microscope view plane as augmented reality, the conventional microscopic and 2D cross-sectional PAM images are concurrently mapped on the plane via an ocular lens of the microscope in real-time. Further, we guided needle insertion into phantom ex vivo and mice skins in vivo. A surgical microscope is a vital tool during operations since it started being used in otolaryngology.1,2 In spite of the continuous improvement of the surgical microscopy performance, it could mainly provide the enlarged surface images without the sub-surface information. Because of this limitation, surgeons are required to have significant experiences and heavy trainings in current clinical practices. Thus, noninvasive visualization of the sub-surface information should play an important role during ophthalmic, microvascular, and neuro-surgeries. 3-5Conventional optical microscopic techniques such as optical coherence tomography (OCT) and fluorescence microscopy (FM) has been applied for this purpose.6-10 OCT mainly provide microstructures of tissues based on optical scattering while the penetration depth of FM is significantly shallow and requires to use the exogenous contrast agents. However, real-time noninvasive mapping of microvasculatures are crucial to verify bleeding regions, guide vascular reconnection, or delineate angiogenesis during the surgeries. 11 To meet this purpose, we are convinced to develop a noninvasive surgical microscopy system to image microvasculatures and surgical intervention without any contrast agent beyond the skin surface in real-time.Photoacoustic microscopy (PAM) is a rising imaging technique that combines optical excitation and ultrasound detection.12-14 Because PAM can provide label-free optical absorption information in a non-invasive manner with high contrast and resolution, this modality has widely been used to image tumor angiogenesis, tumor metabolism, brain function, ocular structures, molecular information, etc. [15][16][17][18][19][20] In this letter, we developed a near-real-time virtual intraoperative surgical photoacoustic microscope (VISPAM) by integrating PAM and conventional surgical microscopy. The VISPAM system could obtain, process, and display both PAM and microscopic images at the same time. The Hilberttransformed cross-sectional PAM B-scan images were projected back onto the microscope view plane as augmented reality through a home-made optical beam splitter, and then the PAM images were shown via the ocular lens mounted on the microscope. Thus, an additional tabletop display is unnecessary, so it is significantly convenient because surgeons potentially do not need to move their sights during the surgeries. We demo...

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Noncontact photoacoustic imaging achieved by using a low-coherence interferometer as the acoustic detector

Cited by 101 publications

References 20 publications

Magnetothermoacoustics from magnetic nanoparticles by short bursting or frequency chirped alternating magnetic field: A theoretical feasibility analysis

Magnetothermoacoustics from magnetic nanoparticles by short bursting or frequency chirped alternating magnetic field: A theoretical feasibility analysis

All-optically integrated photoacoustic and optical coherence tomography: A review

In vivo virtual intraoperative surgical photoacoustic microscopy

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