Noncompliance as a cause of renal graft loss

Graft Failure Due to Noncompliance Among 628 Kidney Transplant Recipients With Long-term Follow-up

“…Earlier studies (28,29,37) reported that the significantly higher risk of medical noncompliance among African Americans (vs. non-Hispanic whites) was completely explained by a lower socioeconomic status (i.e., the effect of race/ethnicity was no longer significant once the effect of socioeconomic status was controlled). However, two international studies (15,42), in which all immunosuppressive medications, outpatient clinical visits, and laboratory work were free of charge to all transplant patients, reported significantly greater noncompliance among younger transplant recipients. Clearly, socioeconomic status did not directly explain why younger patients were more likely to become noncompliant.…”

Two Corticosteroid-Free Regimens—Tacrolimus Monotherapy after Basiliximab Administration and Tacrolimus/Mycophenolate Mofetil—in Comparison with a Standard Triple Regimen in Renal Transplantation: Results of the Atlas Study

“…As diabetes mellitus and hyperlipidemia are key risk factors for posttransplant cardiovascular disease, a major cause of posttransplant mortality (2, 3), corticosteroid-free immunosuppression with basiliximab induction followed by tacrolimus monotherapy may have important clinical long-term implications. Non-compliance with immunosuppressive therapy is a problem in renal transplantation and an important factor contributing to late renal allograft loss (1,(25)(26)(27)(28). Therefore, the administration of fewer immunosuppressive drugs, as is the case with Bas/Tac, and the associated benefits in terms of safety profile, may help improve patient compliance.…”

Prospective Study on Late Consequences of Subclinical Non-Compliance with Immunosuppressive Therapy in Renal Transplant Patients

“…Increasing evidence shows that also non-compliance has a negative impact on graft function, late acute-rejection episodes, organ loss and in some transplant populations death (7)(8)(9)13). Successful outcome in renal transplantation depends on the continued use of immunosuppressive medication.…”