Noncoeliac enteropathy: the differential diagnosis of villous atrophy in contemporary clinical practice

Pallav, Kumar; Leffler, Daniel A.; Tariq, Sohaib; Kabbani, Toufic; Hansen, Joshua; Peer, Ann; Bhansali, Arjun; Najarían, Robert M.; Kelly, Ciarán P.

doi:10.1111/j.1365-2036.2011.04938.x

Cited by 90 publications

(87 citation statements)

References 38 publications

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“…However, these findings are not specific for PLE and can be found in various intestinal diseases, including celiac disease (11). Celiac disease occurs in 4.6-7.1% of individuals with Down syndrome (12).…”

Section: Discussionmentioning

confidence: 87%

Immune-mediated Protein-losing Enteropathy with Down Syndrome

et al. 2014

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A 28-year-old woman previously diagnosed to have Down syndrome presented with a one-month history of severe hypoalbuminemia, lower extremity edema, and diarrhea. Her urine was negative for protein. She was diagnosed with immune-mediated protein-losing enteropathy (PLE) based on clinical findings, protein loss evident on 99m Technetium-labeled human serum albumin scintigraphy, and IgM and complement C3 deposition in the duodenum. She did not exhibit any manifestations of collagen diseases. A dramatic remission was achieved and maintained with corticosteroid administration. This is the first report of immunemediated PLE in a patient with Down syndrome.

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Section: Discussionmentioning

confidence: 87%

Immune-mediated Protein-losing Enteropathy with Down Syndrome

et al. 2014

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“…[6][7][8][9] Increased IELs are also present in~70% of patients with noncoeliac enteropathy. 10 Furthermore, mild intraepithelial lymphocytosis has also been described in healthy individuals with varying prevalence in different studies. [11][12][13] Because the presence and titres of coeliac-associated antibodies are known to correlate with the extent of pathological damage, 14 finding…”

Section: Discussionmentioning

confidence: 99%

Duodenal intraepithelial lymphocytosis is common in children without coeliac disease, and is not meaningfully influenced by Helicobacter pylori infection

Guz‐Mark

Zevit

Morgenstern

et al. 2014

Aliment Pharmacol Ther

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“…None of these patients were prescribed systemic steroids or immunosuppressants and all completely recovered after olmesartan was stopped. In these four patients, the median time from the first symptoms to olmesartan cessation was 3 months [1][2][3][4] and the median duration of symptoms was 3 months [2][3][4]. Comparatively, in the rest of the cohort, the median time from the first symptoms to olmesartan cessation was 9 months [0-68] and the median duration of symptoms was 11 months .…”

Section: Outcomementioning

confidence: 99%