Noncoding RNAs: Regulating the crosstalk between tumor-associated macrophages and gastrointestinal cancer

Wang, Bingyu; Tan, Bibo

doi:10.1016/j.biopha.2022.113370

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2023

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“…Tumor‐associated macrophages (TAMs) are macrophages differentiated from monocytes that are recruited to tumor tissues through chemokines in the tumor microenvironment. 1 An increasing number of studies have found that TAMs play an important role in a variety of tumors, such as liver cancer, 2 breast cancer, 3 gastrointestinal cancer, 4 ovarian cancer. 5 Therefore, TAMs have become a hot spot in cancer research in recent years.…”

Section: Introductionmentioning

confidence: 99%

The role of tumor‐associated macrophages in hepatocellular carcinoma progression: A narrative review

Zhang,

Yu,

Zhao

et al. 2023

Cancer Medicine

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Hepatocellular carcinoma (HCC) is one of the most common malignant tumors in the world, with complex etiology and mechanism, and a high mortality rate. Tumor‐associated macrophages (TAMs) are an important part of the HCC tumor microenvironment. Studies in recent years have shown that TAMs are involved in multiple stages of HCC and are related to treatment and prognosis in HCC. The specific mechanisms between TAMs and HCC are gradually being revealed. This paper reviews recent advances in the mechanisms associated with TAMs in HCC, concentrating on an overview of effects of TAMs on drug resistance in HCC and the signaling pathways linked with HCC, providing clues for the treatment and prognosis determination of HCC.

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