Noncoding RNAs involved in the STAT3 pathway in glioma

Zheng, Bin; Ji, Wei; Xu, Bin; Huo, Zhengyuan; Huang, Hui; Huang, Jin; Jiao, Jiantong; Shao, Jianghua; Zhang, Xiaolu

doi:10.1186/s12935-021-02144-y

Cited by 19 publications

(17 citation statements)

References 105 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…STAT3 activation has been observed in many human cancers, including breast, melanoma, and thyroid cancer 50 , 51 . Evidence points to STAT3 playing a critical role in GBM development and progression 52 , and its transcriptional activation is regulated by IL-6-mediated JAK2 27 . STAT3 is an oncogenic transcription factor whose structural and persistent activation of its proteins is highly regulated.…”

Section: Discussionmentioning

confidence: 99%

Inhibition of STAT3 signaling as critical molecular event in HUC-MSCs suppressed Glioblastoma Cells

Wang¹,

Zhang²,

Liu³

et al. 2023

J. Cancer

View full text Add to dashboard Cite

Objective: We investigated the effect of human umbilical cord mesenchymal stem cells (HUC-MSCs) supernatants on proliferation, migration, invasion, and apoptosis in glioblastoma (GBM) cell lines RG-2, U251, U87-MG, and LN-428, as well as their apoptosis and autophagy-mediated through IL-6/JAK2/STAT3 signaling pathway to explore the molecular mechanisms. Methods: In this study, RG-2, U251, U87-MG, and LN-428 cells were treated with 9 mg/ml HUC-MSCs supernatants. Their responses to HUC-MSCs supernatants treatment and the status of STAT3 signaling were analyzed by multiple experimental approaches to elucidate the importance of HUC-MSCs supernatants for GBM. Results: The results demonstrated that after treatment with HUC-MSCs supernatants, in vitro proliferation of RG-2, U251, U87-MG, and LN-428 cells were inhibited, and their sustained growth was also blocked. RG-2, U251, and U87-MG cells showed significant S phase accumulation, while LN-428 cells were blocked in G0/G1 phase. Their migratory invasive capacities were inhibited, and their apoptosis and autophagy ratios were increased. These effects were mediated through the IL-6/JAK2/STAT3 and its downstream signaling pathway. Conclusion: Our data showed that HUC-MSCs supernatants had anti-tumor effects on GBM cells. It inhibited the proliferation, migration, and invasion of GBM cells and promoted their apoptosis. Negative regulation of the IL-6/JAK2/STAT3 signaling pathway enhanced apoptosis and autophagy in tumor cells, thereby improving the therapeutic effect on GBM.

show abstract

Section: Discussionmentioning

confidence: 99%

Inhibition of STAT3 signaling as critical molecular event in HUC-MSCs suppressed Glioblastoma Cells

Wang¹,

Zhang²,

Liu³

et al. 2023

J. Cancer

View full text Add to dashboard Cite

show abstract

“…It was shown that Stat3 and miR-21 closely interact, 40 and the complex interplay between non-coding RNAs (including miR-21) and Stat3 related to its function in glioma has recently been thoroughly reviewed. 41 Moreover, miR-21 downregulates human telomerase reverse transcriptase expression through its action on Stat3, inhibiting glioma cell growth. 42 Therefore, glioma cells lacking miR-21 might upregulate the Stat3 pathways involved in tumor progression.…”

Section: Discussionmentioning

confidence: 99%

CRISPR-Cas knockout of miR21 reduces glioma growth

Nieland

Solinge

Cheah

et al. 2022

Molecular Therapy - Oncolytics

View full text Add to dashboard Cite

“…The ncRNAs can be classified into small ncRNAs (sncRNAs, 18-200 nt), lncRNAs (>200 nt), and circRANs with a unique loop structure, based on the 200 nt cut-offs of their mature transcript length ( Bian et al, 2021 ). The small ncRNAs can be divided into small nuclear RNAs (snRNAs), small nucleolar RNAs (snoRNAs), miRNAs, and piRNAs ( Pinho et al, 2022 ).…”

Section: Regulation Of Tgf-β/smad Signaling Pathway By Ncrnas In Card...mentioning

confidence: 99%

Mechanism of action of non-coding RNAs and traditional Chinese medicine in myocardial fibrosis: Focus on the TGF-β/Smad signaling pathway

Meng²,

Wang³

et al. 2023

Front. Pharmacol.

View full text Add to dashboard Cite

Cardiac fibrosis is a serious public health problem worldwide that is closely linked to progression of many cardiovascular diseases (CVDs) and adversely affects both the disease process and clinical prognosis. Numerous studies have shown that the TGF-β/Smad signaling pathway plays a key role in the progression of cardiac fibrosis. Therefore, targeted inhibition of the TGF-β/Smad signaling pathway may be a therapeutic measure for cardiac fibrosis. Currently, as the investigation on non-coding RNAs (ncRNAs) move forward, a variety of ncRNAs targeting TGF-β and its downstream Smad proteins have attracted high attention. Besides, Traditional Chinese Medicine (TCM) has been widely used in treating the cardiac fibrosis. As more and more molecular mechanisms of natural products, herbal formulas, and proprietary Chinese medicines are revealed, TCM has been proven to act on cardiac fibrosis by modulating multiple targets and signaling pathways, especially the TGF-β/Smad. Therefore, this work summarizes the roles of TGF-β/Smad classical and non-classical signaling pathways in the cardiac fibrosis, and discusses the recent research advances in ncRNAs targeting the TGF-β/Smad signaling pathway and TCM against cardiac fibrosis. It is hoped, in this way, to give new insights into the prevention and treatment of cardiac fibrosis.

show abstract

Noncoding RNAs involved in the STAT3 pathway in glioma

Cited by 19 publications

References 105 publications

Inhibition of STAT3 signaling as critical molecular event in HUC-MSCs suppressed Glioblastoma Cells

Inhibition of STAT3 signaling as critical molecular event in HUC-MSCs suppressed Glioblastoma Cells

CRISPR-Cas knockout of miR21 reduces glioma growth

Mechanism of action of non-coding RNAs and traditional Chinese medicine in myocardial fibrosis: Focus on the TGF-β/Smad signaling pathway

Contact Info

Product

Resources

About