Noncoding RNAs in tumor metastasis: molecular and clinical perspectives

Liu, Qiu-Luo; Zhang, Zhe; Wei, Xiawei; Zhou, Zong‐Guang

doi:10.1007/s00018-021-03929-0

Cited by 22 publications

(19 citation statements)

References 236 publications

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“…Therefore, inhibition of tumor metastasis is extremely important in lung cancer treatment. Tumor metastasis is a complex multistep process related to cell migration, invasion, epithelial-to-mesenchymal transition (EMT), ECM degradation and intravascular circulation ( Xu et al, 2014 ; Liu et al, 2021 ). Among these processes, the degradation of ECM is a critical step during the development of tumor metastasis ( Eble and Niland, 2019 ).…”

Section: Resultsmentioning

confidence: 99%

Manganese-Based Prussian Blue Nanocatalysts Suppress Non-Small Cell Lung Cancer Growth and Metastasis via Photothermal and Chemodynamic Therapy

Fang

Liu²,

Jin³

et al. 2022

Front. Bioeng. Biotechnol.

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Based on the safety of prussian blue (PB) in biomedical application, we prepared manganese-based prussian blue (MnPB) nanocatalysts to achieve enhanced photothermal therapy and chemodynamic therapy. And we conducted a series of experiments to explore the therapeutic effects of MnPB nanoparticles (NPs) on non-small cell lung cancer (NSCLC) in vivo and in vitro. For in vitro experiments, the MnPB NPs suppressed growth of A549 cells by reactive oxygen species upregulation and near-infrared irradiation. Moreover, the MnPB NPs could inhibit lung cancer metastasis through downregulating the matrix metalloproteinase (MMP)-2 and MMP-9 expression in A549 cells. And for in vivo experiments, the MnPB NPs inhibited the growth of xenografted tumor effectively and were biologically safe. Meanwhile, Mn2+ as a T1-weighted agent could realize magnetic resonance imaging-guided diagnosis and treatment. To sum up, the results in this study clearly demonstrated that the MnPB NPs had remarkable effects for inhibiting the growth and metastasis of NSCLC and might serve as a promising multifunctional nanoplatform for NSCLC treatment.

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Section: Resultsmentioning

confidence: 99%

Manganese-Based Prussian Blue Nanocatalysts Suppress Non-Small Cell Lung Cancer Growth and Metastasis via Photothermal and Chemodynamic Therapy

Fang

Liu²,

Jin³

et al. 2022

Front. Bioeng. Biotechnol.

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“…Recent studies have reported that MALAT1 exhibits both oncogenic and tumor suppressive functions ( 20 , 34 ). Initially, MALAT1 was identified as a prognostic factor for early-stage non-small cell lung cancer metastasis ( 11 ); subsequent studies found that MALAT1overexpression was associated with poor outcomes in various cancers ( 35 ).…”

Section: Discussionmentioning

confidence: 99%

Long Noncoding RNA MALAT1 and Colorectal Cancer: A Propensity Score Analysis of Two Prospective Cohorts

Zhang

Liu

et al. 2022

Front. Oncol.

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BackgroundPrevious researches have shown that the aberrant expression of Metastasis associated in lung adenocarcinoma transcript 1 (MALAT1) in tumour tissues may serve as a biomarker for colorectal cancer (CRC) prognosis. However, these previous studies have small sample sizes and lacked validation from independent external populations. We therefore aimed to clarify the prognostic value of MALAT1 expression status in CRC patients using a large cohort and validate the findings with another large external cohort.MethodsThe prognostic association between MALAT1 expression status and CRC outcomes was evaluated initially in a prospective cohort in China (n=164) and then validated in an external TCGA population (n=596). In the initial cohort, MALAT1 expression levels were quantified by quantitative reverse transcriptase polymerase chain reaction. Propensity score (PS) adjustment method was used to control potential confounding biases. The prognostic significance was reported as PS-adjusted hazard ratio (HR) and corresponding 95% confidence interval (CI).ResultsThere was no statistically significant association between MALAT1 expression status and CRC patient overall survival (OS) or disease free survival (DFS) in both initial cohort and external validation cohort populations. When combining these populations together, the results did not change materially. The summarized HRPS-adjusted were 1.010 (95% CI, 0.752-1.355, P=0.950) and 1.170 (95% CI, 0.910-1.502, P=0.220) for OS and DFS, respectively.ConclusionsMALAT1 expression status is not associated with prognostic outcomes of CRC patients. However, additional larger population studies are needed to further validate these findings.

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“…Some of the major proteins and signaling pathways that contribute to the progression and metastasis of cancer include anomalous p53, PI3K/AKT/mTOR, EGFR, VEGF and Wnt/β-catenin signaling [4][5][6][7][8][9]. Furthermore, various cancer phenotypes have been shown to be regulated by the tissue microenvironment, microRNAs and epigenetic mechanisms [10][11][12].…”

Section: Introductionmentioning

confidence: 99%

A Low Dose Combination of Withaferin A and Caffeic Acid Phenethyl Ester Possesses Anti-Metastatic Potential In Vitro: Molecular Targets and Mechanisms

Sari

Dhanjal

Elwakeel

et al. 2022

Cancers

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Withaferin A (Wi-A) and Caffeic Acid Phenethyl Ester (CAPE) are the bioactive ingredients of Ashwagandha (Withania somnifera) and propolis, respectively. Both of these natural compounds have been shown to possess anticancer activity. In the present study, we recruited a low dose of each of these compounds and developed a combination that exhibited remarkably potent anti-migratory and anti-angiogenic activities. Extensive molecular analyses including a cDNA array and expression analyses of the specific gene targets demonstrated that such activities are mediated through their effect on cell adhesion/tight junction proteins (Claudins, E-cadherin), inhibition of canonical Wnt/β-catenin signaling pathways and the consequent downregulation of EMT-signaling proteins (Vimentin, MMPs, VEGF and VEGFR) that play a critical role in cancer metastasis. The data supported that this novel combination of Wi-A and CAPE (Wi-ACAPE, containing 0.5 µM of Wi-A and 10 µM of CAPE) may be recruited for the treatment of metastatic and aggressive cancers and, hence, warrant further evaluation by recruiting a variety of experimental and clinical metastatic models.

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Noncoding RNAs in tumor metastasis: molecular and clinical perspectives

Cited by 22 publications

References 236 publications

Manganese-Based Prussian Blue Nanocatalysts Suppress Non-Small Cell Lung Cancer Growth and Metastasis via Photothermal and Chemodynamic Therapy

Manganese-Based Prussian Blue Nanocatalysts Suppress Non-Small Cell Lung Cancer Growth and Metastasis via Photothermal and Chemodynamic Therapy

Long Noncoding RNA MALAT1 and Colorectal Cancer: A Propensity Score Analysis of Two Prospective Cohorts

A Low Dose Combination of Withaferin A and Caffeic Acid Phenethyl Ester Possesses Anti-Metastatic Potential In Vitro: Molecular Targets and Mechanisms

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