Noncoding RNAs in subchondral bone osteoclast function and their therapeutic potential for osteoarthritis

Duan, Li; Liang, Yujie; Xu, Xiao; Wang, Jifeng; Li, Xingfu; Sun, Deshun; Deng, Zhiqin; Li, Wen‐Cui; Wang, Daping

doi:10.1186/s13075-020-02374-x

Cited by 28 publications

(13 citation statements)

References 55 publications

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“…Increased numbers and activity of osteoclasts are responsible for bone destruction in abnormal metabolic bone diseases such as osteoporosis, osteoarthritis, and malignancies (Stopeck 2017 ; Duan et al. 2020 ; Yu et al. 2021 ).…”

Section: Discussionmentioning

confidence: 99%

Regulation of bone and fat balance by Fructus Ligustri Lucidi in ovariectomized mice

Qin

Wei

et al. 2023

Pharmaceutical Biology

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Context Fructus Ligustri Lucidi (FLL), a commonly used herb of traditional Chinese medicine (TCM), is the fruit of Ligustrum lucidum Ait. (Oleaceae). The ethanol extract of FLL is a potential candidate for preventing and treating postmenopausal osteoporosis (PMOP) by nourishing the liver and kidneys. Objective This study determines whether an ethanol extract of FLL has anti-osteoporotic effects in ovariectomized (OVX) mice and explores the underlying mechanism. Materials and methods The OVX model of eight-week-old C57BL/6J female mice was taken, and ovariectomy was used as PMOP. Mice were divided into five groups: sham-operated group ( n = 10), OVX group ( n = 10), OVX + E 2 group ( n = 10; 0.039 mg/kg), OVX + FLL group ( n = 10; 2 g/kg) and OVX + FLL group ( n = 10; 4 g/kg). Mice were treated by gavage with FLL or CMCNa once daily for 8 weeks. We harvested uteri, femur, and tibias from mice; bone mineral density (BMD) and bone microstructure were obtained by X-ray absorptiometry and micro-CT. Furthermore, the effect of FLL on the balance of osteoblast and adipocyte differentiation was investigated using bone marrow mesenchymal stem cells (BMMSCs). Results The results indicated that FLL did not affect OVX-induced estradiol reduction. Compared with OVX mice, FLL significantly increased BMD (63.54 vs. 61.96), Conn. D (86.46 vs. 57.00), and left tibial strength (13.91 vs. 11.27), decreased Tb. Sp (0.38 vs. 0.44) and body fat content (4.19% vs. 11.24%). FLL decreased osteoclast activity and enhanced RUNX2 expression; inhibited perilipin peroxisome proliferator-activated receptor gamma (PPARγ) expression and adipocyte differentiation from BMMSCs. Conclusions FLL prevented additional bone loss and improved bone microstructure in OVX mice by modulating bone and fat balance, suggesting that FLL might be a therapeutic agent for PMOP.

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Section: Discussionmentioning

confidence: 99%

Regulation of bone and fat balance by Fructus Ligustri Lucidi in ovariectomized mice

Qin

Wei

et al. 2023

Pharmaceutical Biology

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“…At present, the incidence of OA is very high, and its pathogenesis is still unclear. Studying the specific pathological process and molecular pathway of OA is of great clinical significance ( Duan et al, 2020 ). First, ncRNA can be used to diagnose OA.…”

Section: Discussionmentioning

confidence: 99%

Crosstalk Among circRNA/lncRNA, miRNA, and mRNA in Osteoarthritis

Kong

Sun

Zhang

et al. 2021

Front. Cell Dev. Biol.

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Osteoarthritis (OA) is a joint disease that is pervasive in life, and the incidence and mortality of OA are increasing, causing many adverse effects on people’s life. Therefore, it is very vital to identify new biomarkers and therapeutic targets in the clinical diagnosis and treatment of OA. ncRNA is a nonprotein-coding RNA that does not translate into proteins but participates in protein translation. At the RNA level, it can perform biological functions. Many studies have found that miRNA, lncRNA, and circRNA are closely related to the course of OA and play important regulatory roles in transcription, post-transcription, and post-translation, which can be used as biological targets for the prevention, diagnosis, and treatment of OA. In this review, we summarized and described the various roles of different types of miRNA, lncRNA, and circRNA in OA, the roles of different lncRNA/circRNA-miRNA-mRNA axis in OA, and the possible prospects of these ncRNAs in clinical application.

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“…These ncRNAs, such as microRNA (miRNA), long noncoding RNA (lncRNA), and circular RNA (circRNA), are involved in the pathological development of OA, which can be used as diagnostic and therapeutic markers for OA progression and prognosis. Recent preclinical evidence shows that many ncRNAs can directly affect the expression of key genes involved in OA, which have great translational potential in OA treatment ( Duan et al, 2020 ). Future research on elucidating the role of ncRNAs will also help in better understanding the etiology of OA.…”

Section: Methodsmentioning

confidence: 99%

Recent Advances in Pharmacological Intervention of Osteoarthritis: A Biological Aspect

Deng

Zong

et al. 2021

Front. Pharmacol.

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Osteoarthritis (OA) is a degenerative joint disease in the musculoskeletal system with a relatively high incidence and disability rate in the elderly. It is characterized by the degradation of articular cartilage, inflammation of the synovial membrane, and abnormal structure in the periarticular and subchondral bones. Although progress has been made in uncovering the molecular mechanism, the etiology of OA is still complicated and unclear. Nevertheless, there is no treatment method that can effectively prevent or reverse the deterioration of cartilage and bone structure. In recent years, in the field of pharmacology, research focus has shifted to disease prevention and early treatment rather than disease modification in OA. Biologic agents become more and more attractive as their direct or indirect intervention effects on the initiation or development of OA. In this review, we will discuss a wide spectrum of biologic agents ranging from DNA, noncoding RNA, exosome, platelet-rich plasma (PRP), to protein. We searched for key words such as OA, DNA, gene, RNA, exosome, PRP, protein, and so on. From the pharmacological aspect, stem cell therapy is a very special technique, which is not included in this review. The literatures ranging from January 2016 to August 2021 were included and summarized. In this review, we aim to help readers have a complete and precise understanding of the current pharmacological research progress in the intervention of OA from the biological aspect and provide an indication for the future translational studies.

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Noncoding RNAs in subchondral bone osteoclast function and their therapeutic potential for osteoarthritis

Cited by 28 publications

References 55 publications

Regulation of bone and fat balance by Fructus Ligustri Lucidi in ovariectomized mice

Regulation of bone and fat balance by Fructus Ligustri Lucidi in ovariectomized mice

Crosstalk Among circRNA/lncRNA, miRNA, and mRNA in Osteoarthritis

Recent Advances in Pharmacological Intervention of Osteoarthritis: A Biological Aspect

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