Noncoding RNAs in Cancer Immunology

Li, Qian; Liu, Qiang

doi:10.1007/978-981-10-1498-7_9

Cited by 6 publications

(4 citation statements)

References 75 publications

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“…Their unique features include regulation of multiple targets, ability to be secreted into the extracellular space, and the communication linking capacity between tumor cells and the TME. Therefore, studying miRNAs concerning the complex interactions between the tumor cells and their microenvironment is necessary for understanding the tumor progression and, thus, the development of new therapeutic strategies ( Kros et al, 2014 ; Kohlhapp et al, 2015 ; Li and Liu, 2016 ).…”

Section: Microglia and Astrocytes’ Role In Glioblastoma Malignancymentioning

confidence: 99%

Microglia/Astrocytes–Glioblastoma Crosstalk: Crucial Molecular Mechanisms and Microenvironmental Factors

Matias

Balça-Silva

Graça

et al. 2018

Front. Cell. Neurosci.

130

120

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In recent years, the functions of glial cells, namely, astrocytes and microglia, have gained prominence in several diseases of the central nervous system, especially in glioblastoma (GB), the most malignant primary brain tumor that leads to poor clinical outcomes. Studies showed that microglial cells or astrocytes play a critical role in promoting GB growth. Based on the recent findings, the complex network of the interaction between microglial/astrocytes cells and GB may constitute a potential therapeutic target to overcome tumor malignancy. In the present review, we summarize the most important mechanisms and functions of the molecular factors involved in the microglia or astrocytes–GB interactions, which is particularly the alterations that occur in the cell’s extracellular matrix and the cytoskeleton. We overview the cytokines, chemokines, neurotrophic, morphogenic, metabolic factors, and non-coding RNAs actions crucial to these interactions. We have also discussed the most recent studies regarding the mechanisms of transportation and communication between microglial/astrocytes – GB cells, namely through the ABC transporters or by extracellular vesicles. Lastly, we highlight the therapeutic challenges and improvements regarding the crosstalk between these glial cells and GB.

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Section: Microglia and Astrocytes’ Role In Glioblastoma Malignancymentioning

confidence: 99%

Microglia/Astrocytes–Glioblastoma Crosstalk: Crucial Molecular Mechanisms and Microenvironmental Factors

Matias

Balça-Silva

Graça

et al. 2018

Front. Cell. Neurosci.

130

120

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“…WFDC21P, namely lnc-dendritic cell (lnc-DC) has been observed to be exclusively expressed in human DCs and mediates the differentiation of monocytes to DCs via the activation of signal transducer and activator of transcription 3, which is a transcription factor that regulates numerous immune-associated genes ( 25 , 26 ). Wu et al ( 27 ) suggested that lnc-DC in plasma may be a possible biomarker for systemic lupus erythematosus.…”

Section: Discussionmentioning

confidence: 99%

Identification of a 5‑lncRNA signature‑based risk scoring system for survival prediction in colorectal cancer

Wang

et al. 2018

Mol Med Report

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The present study aimed to investigate potential prognostic long noncoding RNAs (lncRNAs) associated with colorectal cancer (CRC). An mRNA-seq dataset obtained from The Cancer Genome Atlas was employed to identify the differentially expressed lncRNAs (DELs) between CRC patients with good and poor prognoses. Subsequently, univariate and multivariate Cox regression analyses were conducted to analyze the prognosis-associated lncRNAs among all DELs. In addition, a risk scoring system was developed according to the expression levels of the prognostic lncRNAs, which was then applied to a training set and an independent testing set. Furthermore, the co-expressed genes of prognostic lncRNAs were screened using a Multi-Experiment Matrix online tool for construction of lncRNA-gene networks. Finally, Kyoto Encyclopedia of Genes and Genomes pathway and Gene Ontology (GO) function enrichment analyses were performed on genes in the lncRNA-gene networks using KOBAS, GOATOOLS and ClusterProfiler. The present study identified 82 DELs, of which long intergenic nonprotein coding RNA 2159, RP11-452L6.6, RP11-894P9.1 and RP11-69M1.6, and whey acidic protein four-disulfide core domain 21 (WFDC21P) were reported to be independently associated with the prognosis of patients with CRC. A 5-lncRNA signature-based risk scoring system was developed, which may be used to classify patients into low- and high-risk groups with significantly different recurrence-free survival times in the training and testing sets (P<0.05). Co-expressed genes of WFDC21P or RP11-69M1.6 were utilized to construct the lncRNA-gene networks. Genes in the networks were significantly enriched in ‘tight junction’, ‘focal adhesion’ and ‘regulation of actin cytoskeleton’ pathways, and numerous GO terms associated with ‘reactive oxygen species metabolism’ and ‘nitric oxide metabolism’. The present study proposed a 5-lncRNA signature-based risk scoring system for predicting the prognosis of patients with CRC, and revealed the associated signaling pathways and biological processes. The results of the present study may help improve prognostic evaluation in clinical practice.

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“…(5) other unconventional miRNA functions (44). Despite the continued emergence of new species, nowadays, most reports are focused on miRNA and lncRNA and great progress has been made (45).…”

Section: The Achievement In This Fieldmentioning

confidence: 99%

Noncoding RNA in Extracellular Vesicles Regulate Differentiation of Mesenchymal Stem Cells

Yan

2022

Front. Dent. Med

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To achieve the desired outcome in tissue engineering regeneration, mesenchymal stem cells need to undergo a series of biological processes, including differentiating into the ideal target cells. The extracellular vesicle (EV) in the microenvironment contributes toward determining the fate of the cells with epigenetic regulation, particularly from noncoding RNA (ncRNA), and exerts transportation and protective effects on ncRNAs. We focused on the components and functions of ncRNA (particularly microRNA) in the EVs. The EVs modified by the ncRNA favor tissue regeneration and pose a potential challenge.

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Noncoding RNAs in Cancer Immunology

Cited by 6 publications

References 75 publications

Microglia/Astrocytes–Glioblastoma Crosstalk: Crucial Molecular Mechanisms and Microenvironmental Factors

Microglia/Astrocytes–Glioblastoma Crosstalk: Crucial Molecular Mechanisms and Microenvironmental Factors

Identification of a 5‑lncRNA signature‑based risk scoring system for survival prediction in colorectal cancer

Noncoding RNA in Extracellular Vesicles Regulate Differentiation of Mesenchymal Stem Cells

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