Noncoding RNAs in Cancer Diagnosis

Zeng, Mu‐Sheng

doi:10.1007/978-981-10-1498-7_15

Cited by 10 publications

(6 citation statements)

References 220 publications

(141 reference statements)

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“…Increasing evidences revealed that non-coding RNAs, particularly lncRNAs and miRNAs, have considerable potential values in improving the diagnostic and therapeutic of GC. 25,26 Researchers have found a large number of lncRNAs in GC development, such as lncRNA HOXC-AS3, 27 LINC01234 4 and lncRNA-KRTAP5-AS1. 28 Aberrantly expressed lncRNAs are involved in various malignant cytological behaviours of GC cells.…”

Section: Discussionmentioning

confidence: 99%

Long non‐coding RNA MYOSLID functions as a competing endogenous RNA to regulate MCL‐1 expression by sponging miR‐29c‐3p in gastric cancer

Han

Jiang

et al. 2019

Cell Proliferation

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Objective Long non‐coding RNA (lncRNA) has become an important regulator of many human malignancies. However, the biological role and clinical significance of most lncRNA in gastric cancer (GC) remain unclear. Methods We investigate the biological function, mechanism of action and clinical expression of lncRNA MYOSLID in GC. First, we analysed the differential expression of lncRNA MYOSLID in GC tissues and non‐cancerous tissues by analysing the sequencing data obtained from The Cancer Genome Atlas. Subsequently, we verified that lncRNA MYOSLID regulates the proliferation and apoptosis of GC cells by acting as a ceRNA against miR‐29c‐3p. The nude mouse xenograft was used to further confirm the functional significance of lncRNA MYOSLID in vivo. Results We found for the first time that the expression of lncRNA MYOSLID was significantly up‐regulated in GC tissues, and the up‐regulation of lncRNA MYOSLID in GC was correlated with tumour size, AJCC stage, depth of invasion and survival time. In addition, apoptosis and growth arrest can be induced in vitro after knockdown of lncRNA MYOSLID, which inhibits tumorigenesis in mouse xenografts in vivo. Further in‐depth studies revealed that lncRNA MYOSLID acts as a ceRNA of miR‐29c‐3p, resulting in de‐repression of its downstream target gene MCL‐1. Conclusion The lncRNA MYOSLID‐miR‐29c‐3p‐MCL‐1 axis plays a key role in the development of GC. Our findings may provide potential new targets for the diagnosis and treatment of human GC.

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Section: Discussionmentioning

confidence: 99%

Long non‐coding RNA MYOSLID functions as a competing endogenous RNA to regulate MCL‐1 expression by sponging miR‐29c‐3p in gastric cancer

Han

Jiang

et al. 2019

Cell Proliferation

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“…The identification of new targets involved in NSCLC tumor genesis may result in the development of novel diagnostic and prognostic strategies. Recently, with the application of high‐throughput sequencing and bioinformatics, more and more dysregulated lncRNAs have been identified in various tumor tissues, including NSCLC 24,25 . In addition, a growing number of studies have shed light on the biogenesis and function of lncRNAs.…”

Section: Discussionmentioning

confidence: 99%

Increased levels of long noncoding RNA LINC00691 correlate with poor prognosis in non–small‐cell lung cancer patients

Xie

2020

Clinical Laboratory Analysis

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Background Although long intergenic non‐protein coding RNA 691 (LINC00691) has been functionally identified in several tumors, the association between LINC00691 and non–small‐cell lung cancer (NSCLC) has not been reported. The objective of our study was to explore the clinical significance of LINC00691 in NSCLC. Methods RT‐PCR was performed to detect LINC00691 levels in 177 pairs of human NSCLC tissues and matched normal lung specimens. A chi‐squared test was used to analyze the possible influence of LINC00691 on the clinical progress of NSCLC. Kaplan‐Meier methods were used to determine differences in patient survival. The prognostic value of survival variables was evaluated using univariate and multivariate analyses. Results We found that LINC00691 levels were increased in tumor specimens compared with matched normal lung tissues ( P < .01). Increased LINC00691 levels correlated with lymph node metastasis ( P = .025) and advanced TNM stage ( P = .002) in NSCLC patients. Moreover, clinical investigations revealed that NSCLC patients with high LINC00691 expression had a shorter overall survival than those with low LINC00691 expression ( P = .0042). Finally, Cox regression assays confirmed LINC00691 as an independent prognostic factor for NSCLC patients. Conclusions The aberrant expression of LINC00691 may function as a reliable marker for the progression and prognosis of NSCLC in patients.

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“…This makes non-coding RNAs a convenient target for suppressing tumor development with minimal possible impact on healthy cells [ 112 ]. Among other things, non-coding RNAs have shown themselves to be a promising marker for the diagnosis of oncogenic diseases [ 113 ]. This diagnostic method is convenient, as non-coding RNAs can be easily detected in the cells and biological fluids of the patient.…”

Section: Introductionmentioning

confidence: 99%

The Role of Non-Coding RNAs in the Regulation of the Proto-Oncogene MYC in Different Types of Cancer

et al. 2021

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Alterations in the expression level of the MYC gene are often found in the cells of various malignant tumors. Overexpressed MYC has been shown to stimulate the main processes of oncogenesis: uncontrolled growth, unlimited cell divisions, avoidance of apoptosis and immune response, changes in cellular metabolism, genomic instability, metastasis, and angiogenesis. Thus, controlling the expression of MYC is considered as an approach for targeted cancer treatment. Since c-Myc is also a crucial regulator of many cellular processes in healthy cells, it is necessary to find ways for selective regulation of MYC expression in tumor cells. Many recent studies have demonstrated that non-coding RNAs play an important role in the regulation of the transcription and translation of this gene and some RNAs directly interact with the c-Myc protein, affecting its stability. In this review, we summarize current data on the regulation of MYC by various non-coding RNAs that can potentially be targeted in specific tumor types.

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Noncoding RNAs in Cancer Diagnosis

Cited by 10 publications

References 220 publications

Long non‐coding RNA MYOSLID functions as a competing endogenous RNA to regulate MCL‐1 expression by sponging miR‐29c‐3p in gastric cancer

Long non‐coding RNA MYOSLID functions as a competing endogenous RNA to regulate MCL‐1 expression by sponging miR‐29c‐3p in gastric cancer

Increased levels of long noncoding RNA LINC00691 correlate with poor prognosis in non–small‐cell lung cancer patients

The Role of Non-Coding RNAs in the Regulation of the Proto-Oncogene MYC in Different Types of Cancer

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