Noncoding RNAs Associated with Therapeutic Resistance in Pancreatic Cancer

Son, Seung Wan; Song, Mun Gyu; Yun, Ba Da; Park, Jong Kook

doi:10.3390/biomedicines9030263

Cited by 6 publications

(6 citation statements)

References 225 publications

(180 reference statements)

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“…Nonetheless, it suggests that lncRNA-based cancer therapy can be a potential strategy against cancers. Growing evidence suggests that the modulation of lncRNA expression sensitizes cancer cells to anti-cancer agents [17,207,208]. Since a therapeutic response can be improved by combination therapy, exploring a novel strategy of lncRNA-based cancer therapy in combination with other hypoxia-targeting agents (e.g., HIF inhibitors and prodrugs) is As mentioned in Sections 2.2.9 and 2.3.1, lncRNAs can behave differently depending on cancer types.…”

Section: Discussionmentioning

confidence: 99%

“…Growing evidence suggests that the modulation of lncRNA expression sensitizes cancer cells to anti-cancer agents [ 17 , 207 , 208 ]. Since a therapeutic response can be improved by combination therapy, exploring a novel strategy of lncRNA-based cancer therapy in combination with other hypoxia-targeting agents (e.g., HIF inhibitors and prodrugs) is worth considering.…”

Section: Discussionmentioning

confidence: 99%

“…LncRNAs can regulate a broad range of cellular signaling regardless of oxygen levels [ 17 , 216 , 217 ], and solid cancers are heterogeneous in terms of oxygenation [ 218 ]. Therefore, targeting an individual lncRNA can have a chance of controlling both well-oxygenated and hypoxic cancer cells.…”

Section: Discussionmentioning

confidence: 99%

“…Hypoxia also activates the epithelial-to-mesenchymal transition (EMT) process and cancer stemness, eventually promoting cancer aggressiveness and metastasis [ 12 , 13 , 14 , 15 , 16 ]. In terms of therapeutic resistance, several cellular factors and events including anti-apoptotic/survival factors, EMT, and stemness are associated with a reduction in the sensitivity of cells to cancer treatments [ 17 , 18 ]. Therefore, hypoxia is considered as one of the causes of drug resistance in cancer.…”

Section: Introductionmentioning

confidence: 99%

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The Hypoxia–Long Noncoding RNA Interaction in Solid Cancers

Son

Yun

Song

et al. 2021

IJMS

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Hypoxia is one of the representative microenvironment features in cancer and is considered to be associated with the dismal prognosis of patients. Hypoxia-driven cellular pathways are largely regulated by hypoxia-inducible factors (HIFs) and notably exert influence on the hallmarks of cancer, such as stemness, angiogenesis, invasion, metastasis, and the resistance towards apoptotic cell death and therapeutic resistance; therefore, hypoxia has been considered as a potential hurdle for cancer therapy. Growing evidence has demonstrated that long noncoding RNAs (lncRNAs) are dysregulated in cancer and take part in gene regulatory networks owing to their various modes of action through interacting with proteins and microRNAs. In this review, we focus attention on the relationship between hypoxia/HIFs and lncRNAs, in company with the possibility of lncRNAs as candidate molecules for controlling cancer.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The Hypoxia–Long Noncoding RNA Interaction in Solid Cancers

Son

Yun

Song

et al. 2021

IJMS

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“…Pancreatic cancer is one of digestive cancers with the highest mortality rate [ 14 ]. Most cases of pancreatic cancer are generally diagnosed in advanced stages, with poor treatment outcomes and poor prognosis [ 15 ].…”

Section: Discussionmentioning

confidence: 99%

CircSEC24A upregulates TGFBR2 expression to accelerate pancreatic cancer proliferation and migration via sponging to miR-606

Chen

Liu

et al. 2021

Cancer Cell Int

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Background Circular RNA (circRNA), producing by special selective splicing, was widely expressed in the cytoplasm of eukaryotic cells as a newly non-coding RNAs. It played different roles in a variety of diseases including cancer and performed different functions. Nonetheless, reports on the specific function of circRNA in pancreatic cancer (PC) were still rarely so far. In particular, the role of circSEC24A in PC remains unclear. Methods Real-time fluorescent quantitative PCR was used to evaluate the expression level of circSEC24A in pancreatic cancer tissues and cell lines. Furthermore, we used some functional experiments, such as EDU and Transwell assays, to explore the effects of circSEC24A on the proliferation and invasiveness of pancreatic cancer. Finally, the corresponding relationship among circSEC24A, miR-606 and TGFBR2 was explored by dual luciferase reporter and other mechanism studies. Results The expression of circSEC24A in both pancreatic cancer tissues and cell lines was evidently up-regulated. Furthermore, knockdown of circSEC24A significantly inhibited the proliferative, migration and invasive capacity of pancreatic cancer cells, whereas miR-606 inhibitor obviously counteracted these effects. Further study confirmed that circSEC24A alleviated suppression on target TGFBR2 expression by directly sponging miR-606 and then influenced the tumorigenesis of pancreatic cancer. Conclusions These findings indicated that the progression of pancreatic cancer can be driven by circSEC24A influencing miR-606/TGFBR2 axis. Therefore, circSEC24A might be used as a critical biomarker influencing the early diagnosis and prognosis of pancreatic cancer.

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