Nonclinical Evaluation of Compound‐Related Cytopenias

O'Rourke, Laurie G.

doi:10.1002/9781119500537.ch12

Cited by 1 publication

(1 citation statement)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Hematopoiesis occurs in the bone marrow of healthy adult birds. Extramedullary hematopoiesis in the liver is induced by specific cytokines and growth factors when decreased production in the bone marrow does not meet the need for circulating erythrocytes and/or leukocytes (O'Rourke 2021). This suggests that there may be toxicant‐induced bone marrow dysfunction and adequate numbers of blood cells are not being produced.…”

Section: Discussionmentioning

confidence: 99%

Dietary Exposure of Japanese Quail (Coturnix japonica) to Perfluorooctane Sulfonate (PFOS) and a Legacy Aqueous Film‐Forming Foam (AFFF) Containing PFOS: Effects on Reproduction and Chick Survivability and Growth

Bursian

Link

McCarty

et al. 2021

Enviro Toxic and Chemistry

View full text Add to dashboard Cite

Effects of perfluorooctane sulfonate (PFOS) and a legacy aqueous film‐forming foam (AFFF) containing 91% PFOS (AFFF PFOS) on reproduction, chick survivability, and growth of Japanese quail (Coturnix japonica) were determined. Day‐old Japanese quail were administered PFOS or AFFF PFOS at 6 dietary concentrations ranging from 0 to 21 mg kg–1 feed for a total of 20 wk. At the age of 4 wk, 16 male/female pairs per treatment were assigned to cages, and egg laying was induced by the age of 10 wk. Eggs were collected daily, set weekly, and incubated for 18 d for the following 10 wk. Hatchlings were fed uncontaminated feed for 2 wk and euthanized to collect blood and liver. After 10 wk of egg collection, adults were euthanized to collect blood, liver, and kidneys. Significantly increased myofiber numbers in the liver and glomerular sclerosis in the kidneys of adults indicated damage at greater doses. Perfluorooctane sulfonate or AFFF PFOS did not significantly affect egg production; however, hatchability was decreased at the highest PFOS dose. The no‐observed‐adverse‐effect levels for chick survivability, considered the critical effect, were 4.1 mg PFOS kg feed–1 (0.55 mg kg body wt–1 d–1) and 5.0 mg AFFF PFOS kg feed–1 (0.66 mg kg body wt−1 d–1), resulting in calculated average toxicity reference values of 0.25 mg kg feed–1 and 0.034 mg kg body weight–1 d–1. Environ Toxicol Chem 2021;40:2521–2537. © 2020 SETAC

show abstract

Section: Discussionmentioning

confidence: 99%