Noncationic Material Design for Nucleic Acid Delivery

Jiang, Ziwen; Thayumanavan, S.

doi:10.1002/adtp.201900206

Cited by 37 publications

(39 citation statements)

References 265 publications

(106 reference statements)

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“…Conclusively, this review has described a variety of supramolecular architectures that were assembled from both nucleic acids and peptides with structural orders that ranged from the molecular to nano-scales. The rational and modular molecular and structural designs for the construction and engineering of such supramolecular architectures to equip them with desired functions and properties would facilitate the elucidation of their beneficial bio-applications, such as sensor [ 140 ], cell-culturing matrix for regenerative medicine [ 141 , 142 , 143 ], and drug-releasing material [ 144 , 145 , 146 , 147 ]. Furthermore, synergistically combining the strengths of both molecules (nucleic acids and peptides) would be essential to widening the scope of future research projects.…”

Section: Discussionmentioning

confidence: 99%

Supramolecular Architectures of Nucleic Acid/Peptide Hybrids

Higashi

Rozi

Hanifah

et al. 2020

IJMS

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Supramolecular architectures that are built artificially from biomolecules, such as nucleic acids or peptides, with structural hierarchical orders ranging from the molecular to nano-scales have attracted increased attention in molecular science research fields. The engineering of nanostructures with such biomolecule-based supramolecular architectures could offer an opportunity for the development of biocompatible supramolecular (nano)materials. In this review, we highlighted a variety of supramolecular architectures that were assembled from both nucleic acids and peptides through the non-covalent interactions between them or the covalently conjugated molecular hybrids between them.

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Section: Discussionmentioning

confidence: 99%

Supramolecular Architectures of Nucleic Acid/Peptide Hybrids

Higashi

Rozi

Hanifah

et al. 2020

IJMS

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“…Recently, noncationic/neutral nucleic delivery systems have been proposed and designed as promising candidates with reduced toxicity profiles via either neutralizing the cationic moieties within the materials or directly formulating with noncationic materials. [ 113–115 ] Gong et al. developed a ternary multifunctional nucleic acid delivery system ( Figure ).…”

Section: Biomedical Applications Of Polysaccharide–peptide Conjugatesmentioning

confidence: 99%

Polysaccharide–Peptide Conjugates: A Versatile Material Platform for Biomedical Applications

Song

Fan

et al. 2020

Adv Funct Materials

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Natural polymers, such as polysaccharides and proteins, have been widely studied for numerous biomedical applications because of their bioactivity, natural origin, and biodegradability. To address the different needs of a broad spectrum of biomedical applications, natural polymers are modified with or conjugated to small molecular compounds, synthetic and natural polymers, and inorganic nanomaterials and surfaces. Among these hybrid materials, polysaccharide–peptide conjugates have drawn much attention due to their design flexibility, biocompatibility, tunable degradability, and structure similarity to naturally occurring glycoproteins. In the past 20 years, polysaccharide–peptide conjugates have demonstrated the promising potential to address many long‐standing medical challenges. Thus, the design, conjugation chemistry and method, and biomedical applications of polysaccharide–peptide conjugates are summarized and discussed in this review. The conjugation techniques are reviewed from the view of the chemical reactions. Meanwhile, some inspiring examples of polysaccharide–peptide conjugates in biomedical applications, including drug delivery systems, nucleic acid delivery carriers, tissue engineering, and antimicrobial applications, are highlighted. Moreover, the outlook on the challenges and demands of polysaccharide–peptide conjugates is also elaborated.

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“…Also, the anti-FX II aptamer was introduced as an antithrombosis drug by inhibiting the blood coagulation pathway [ 75 , 76 ]. Furthermore, the biocompatibility of aptamer nucleic acids and their low immunogenetic make the aptamers ideal drug targeting carriers, therapeutic agents and functional material for in vivo sensing applications [ 77 , 78 , 79 ].…”

Section: Introductionmentioning

confidence: 99%

Aptamer-Functionalized Hybrid Nanostructures for Sensing, Drug Delivery, Catalysis and Mechanical Applications

Vázquez‐González

Willner

2021

IJMS

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Sequence-specific nucleic acids exhibiting selective recognition properties towards low-molecular-weight substrates and macromolecules (aptamers) find growing interest as functional biopolymers for analysis, medical applications such as imaging, drug delivery and even therapeutic agents, nanotechnology, material science and more. The present perspective article introduces a glossary of examples for diverse applications of aptamers mainly originated from our laboratory. These include the introduction of aptamer-functionalized nanomaterials such as graphene oxide, Ag nanoclusters and semiconductor quantum dots as functional hybrid nanomaterials for optical sensing of target analytes. The use of aptamer-functionalized DNA tetrahedra nanostructures for multiplex analysis and aptamer-loaded metal-organic framework nanoparticles acting as sense-and-treat are introduced. Aptamer-functionalized nano and microcarriers are presented as stimuli-responsive hybrid drug carriers for controlled and targeted drug release, including aptamer-functionalized SiO2 nanoparticles, carbon dots, metal-organic frameworks and microcapsules. A further application of aptamers involves the conjugation of aptamers to catalytic units as a means to mimic enzyme functions “nucleoapzymes”. In addition, the formation and dissociation of aptamer-ligand complexes are applied to develop mechanical molecular devices and to switch nanostructures such as origami scaffolds. Finally, the article discusses future challenges in applying aptamers in material science, nanotechnology and catalysis.

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Noncationic Material Design for Nucleic Acid Delivery

Cited by 37 publications

References 265 publications

Supramolecular Architectures of Nucleic Acid/Peptide Hybrids

Supramolecular Architectures of Nucleic Acid/Peptide Hybrids

Polysaccharide–Peptide Conjugates: A Versatile Material Platform for Biomedical Applications

Aptamer-Functionalized Hybrid Nanostructures for Sensing, Drug Delivery, Catalysis and Mechanical Applications

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