Noncaseating pulmonary granulomas associated with small cell carcinoma of the lung

Lynch, Joseph P.; Flint, Andrew; Miller, Donald M.; Fantone, Joseph C.

doi:10.1016/0002-9343(85)90416-4

Cited by 15 publications

(4 citation statements)

References 24 publications

(8 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In contrast, lung cancer patients [21] and breast cancer patients [22] do not appear to benefit much. There is a remarkable case though reported by Lynch of a patient with small-cell lung cancer that presented itself as pulmonary granulomas, remaining undetected and therefore untreated for twelve months despite the meticulous diagnostic work-up [23]. The authors suggest that maybe the sarcoidal reactions represented a host-defense mechanism against the neoplasm.…”

Section: Discussionmentioning

confidence: 99%

Untitled

2015

JCPCR

View full text Add to dashboard Cite

Sarcoid-like reactions in lymph nodes have been described in cancer patients lacking systemic symptoms and signs of sarcoidosis. They are hypothesized to represent immune host response against the neoplastic cells. Their presence may hinder proper staging resulting in serious therapeutic ramifications, either in the form of overtreatment or less often under treatment. We present two cases of mediastinal lymphadenopathy in cancer patients that was presumed to be due to metastatic disease. Despite the administration of chemotherapy, the lesions persisted necessitating a biopsy that revealed their true nature. These clinical cases emphasize the importance of differential diagnosis of lymphadenopathy in the context of malignant disease.

show abstract

Section: Discussionmentioning

confidence: 99%

Untitled

2015

JCPCR

View full text Add to dashboard Cite

show abstract

“…61 The second hypothesis is that solid tumors are associated with an intense inflammatory reaction from the host defense that can evolve into granulomas. 65 Solid tumors are infiltrated with greater amounts of T cells. Lymphokines produced by infiltrating T cells and macrophages can increase glomerular permeability and cause MCD.…”

Section: Discussionmentioning

confidence: 99%

Minimal Change Disease as a Paraneoplastic Manifestation of Solid Malignant Tumors

Yong

Khow

2012

Nephrology Research & Reviews

View full text Add to dashboard Cite

Solid malignant tumors are associated with a wide range of paraneoplastic manifestations including glomerular diseases. Membranous nephropathy is commonly associated with solid malignancies but minimal change disease (MCD) has predominantly been reported in association with Hodgkin’s lymphoma. The association between MCD and solid malignant tumors has not previously been well described. All case reports and series in the English medical literature of patients with MCD and solid malignant tumors, including malignant thymoma, were systematically reviewed. Thirty-one patients with non-thymoma solid malignant tumors and 26 patients with malignant thymoma associated with MCD were identified. Nephrotic syndrome was present in 91% (52 of 57) of cases. Among those with malignant thymoma and MCD, 16 of 25 (64%) patients whose renal function were reported had impaired renal function, defined as serum creatinine over 120 mmol/L, at the time of presentation. In the solid malignancy group, 15 of 25 (60%) had renal impairment. In the malignant thymoma group, complete, partial or no remission of MCD was observed in 11, 5 and 8 cases, respectively, within the follow-up interval of each report. In the non-thymoma group, 12 of 31 went into complete remission and 10 were in partial remission. Nine cases showed no response to the treatment. There is an association between the activity of MCD and the malignancy status. Death was reported in 15 of 23 patients with solid non-thymoma malignancies and 6 of 13 with malignant thymoma. MCD is associated with solid malignant tumors infrequently as a paraneoplastic manifestation. The response of MCD to treatment and survival of this group of patients can be variable depending on the disease stage of the associated malignancy

show abstract

“…SL reactions are relatively less common in solid tumors as compared to lymphomas. In a study by Lynch et al, the authors found that SL reaction was associated with improved prognosis in small cell carcinoma of the lung [21]. Recently, Steinfort et al [22] studied eight patients with nonsmall cell carcinoma lung where sarcoidal granulomas were present in regional lymph nodes.…”

Section: Prognostic Significancementioning

confidence: 99%

Sarcoid Granulomas in Malignancy

Arora¹,

Kaur²,

Ro³

2020

Sarcoidosis and Granulomatosis - Diagnosis and Management

View full text Add to dashboard Cite

Noncaseating epithelioid granulomas without accompanying systemic symptoms of sarcoidosis have been described in association with many primary tumors where they are designated as sarcoid-like (SL) reaction. Morphologically, this SL reaction is similar to granulomas found in systemic sarcoidosis comprising of focal accumulation of epithelioid cells and multinucleated giant cells. They can be seen either adjacent to the primary malignancy or in local draining lymph nodes. Additionally, sarcoid-like granulomas can affect other organs distant from the primary neoplasm, such as the spleen, bone marrow, and skin. This sarcoid-like reaction is thought to occur as an immunologic T-cell-mediated response to antigens expressed by the neoplastic cells or soluble tumor antigens. Whether the presence of this sarcoid-like reaction has any prognostic significance in the associated neoplasm is unclear.

show abstract

Noncaseating pulmonary granulomas associated with small cell carcinoma of the lung

Cited by 15 publications

References 24 publications

Untitled

Untitled

Minimal Change Disease as a Paraneoplastic Manifestation of Solid Malignant Tumors

Sarcoid Granulomas in Malignancy

Contact Info

Product

Resources

About