Noncanonical Amino Acids: Bringing New-to-Nature Functionalities to Biocatalysis
Bart Brouwer,
Franco Della-Felice,
Jan Hendrik Illies
et al.
Abstract:Biocatalysis has become an important component of modern organic chemistry, presenting an efficient and environmentally friendly approach to synthetic transformations. Advances in molecular biology, computational modeling, and protein engineering have unlocked the full potential of enzymes in various industrial applications. However, the inherent limitations of the natural building blocks have sparked a revolutionary shift. In vivo genetic incorporation of noncanonical amino acids exceeds the conventional 20 a… Show more
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