Noncancer Deaths in White Adult Cancer Patients

Brown, Barry W.; Brauner, Christopher; Minnotte, Michael C.

doi:10.1093/jnci/85.12.979

Cited by 227 publications

(162 citation statements)

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“…Cancer is the underlying cause of death among the vast majority of women with cancer (2, 3). The underlying cause of many "non-cancer" deaths can often be associated directly with nontreatment or even with some cancer treatment complications (35). Although length of survival is highly accurate in these cancer registries, the underlying cause of death is not (14).…”

Section: Discussionmentioning

confidence: 99%

Breast Cancer Survival in Ontario and California, 1998–2006: Socioeconomic Inequity Remains Much Greater in the United States

Gorey¹,

Luginaah²,

Holowaty³

et al. 2009

Annals of Epidemiology

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This study re-examined the differential effect of socioeconomic status on the survival of women with breast cancer in Canada and the United States. Ontario and California cancer registries provided 1,913 cases from urban and rural places. Stage-adjusted cohorts (1998Stage-adjusted cohorts ( -2000 were followed until 2006. Socioeconomic data were taken from population censuses. SES-survival associations were observed in California, but not in Ontario, and Canadian survival advantages in low-income areas were replicated. A better controlled and updated comparison reaffirmed the equity advantage of Canadian health care.

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Section: Discussionmentioning

confidence: 99%

Breast Cancer Survival in Ontario and California, 1998–2006: Socioeconomic Inequity Remains Much Greater in the United States

Gorey¹,

Luginaah²,

Holowaty³

et al. 2009

Annals of Epidemiology

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“…Cancer is the underlying cause of most deaths among younger women with breast cancer [26,27]. Moreover, the underlying cause of many "non-cancer" deaths can often be directly associated with non-treatment or even with some cancer treatment complications [63]. And this study's hypothesized African American disadvantage among younger women was not only observed for survival, but also for receipt of a number of treatments.…”

Section: Study Limitations and Strengthsmentioning

confidence: 86%

Increased racial differences on breast cancer care and survival in America: historical evidence consistent with a health insurance hypothesis, 1975–2001

Gorey

Luginaah

Schwartz

et al. 2008

Breast Cancer Res Treat

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Purpose-This study examined whether race/ethnicity had differential effects on breast cancer care and survival across age strata and cohorts within stages of disease. Methods-TheDetroit Cancer Registry provided 25,997 breast cancer cases. African American and non-Hispanic white, older Medicare-eligible and younger non-eligible women were compared. Successive historical cohorts (1975-1980 and 1990-1995) CIHR Author Manuscript CIHR Author Manuscript CIHR Author ManuscriptResults-African American disadvantages on survival and treatments increased significantly, particularly among younger women who were much more likely to be uninsured. Within node positive disease all treatment disadvantages among younger African American women disappeared with socioeconomic adjustment.Conclusions-Growth of this racial divide implicates social, rather than biological, forces. Its elimination will require high quality health care for all.

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“…16 Men with prostate cancer have higher rates of non-cancer mortality than do men in the general population, and some of the excess non-cancer deaths may be treatment-induced. 17 In men undergoing ADT, metabolic changes are observed often, which may lead to an increased risk of type 2 diabetes, cardiovascular diseases and metabolic syndrome and might contribute to the increase of non-cancer deaths. 18 A review of the literature suggests that male hypogonadism is accompanied by an increased risk of insulin resistance and diabetes mellitus.…”

Section: Discussionmentioning

confidence: 99%

Androgen deprivation therapy through bilateral orchiectomy: increased metabolic risks

Jiang¹,

Zhang²,

Zhang³

et al. 2011

Asian J Androl

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Prostate cancer is one of the most common malignancies in men. Previous research has determined that androgen deprivation therapy (ADT) may be accompanied by an unfavourable metabolic profile. In this prospective study, 133 men were recruited, including 46 prostate cancer patients who had undergone bilateral orchiectomy and been on flutamide (the ADT group), 37 men with prostate cancer who had undergone radical prostatectomy (the non-ADT group) and 50 normal control subjects (the control group). All subjects were followed for at least 12 months. From baseline to 3 months, men in the ADT group had increased levels of fasting serum insulin and low-density lipoprotein compared to the other two groups (P,0.05). No obvious changes were found in the other parameters (P.0.05). After 12 months, men in the ADT group had increased levels of waist circumference, fasting serum insulin and glucose, total cholesterol, high-density lipoprotein and low-density lipoprotein compared to the other two groups (P,0.05). Additionally, the morbidity rate of metabolic syndrome in the ADT group was higher (P,0.05) compared to the other two groups. ADT through surgical castration for men with prostate cancer may be associated with unfavourable metabolic changes. The benefits of the therapy should be balanced prudently against these risks.

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Noncancer Deaths in White Adult Cancer Patients

Cited by 227 publications

References 0 publications

Breast Cancer Survival in Ontario and California, 1998–2006: Socioeconomic Inequity Remains Much Greater in the United States

Breast Cancer Survival in Ontario and California, 1998–2006: Socioeconomic Inequity Remains Much Greater in the United States

Increased racial differences on breast cancer care and survival in America: historical evidence consistent with a health insurance hypothesis, 1975–2001

Androgen deprivation therapy through bilateral orchiectomy: increased metabolic risks

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