Nonbladder Related Symptoms in Patients With Interstitial Cystitis

Erickson, Deborah; Morgan, K.; Ordille, Sarah; Keay, Susan; Xie, Sharon X.

doi:10.1016/s0022-5347(05)65984-8

Cited by 66 publications

(15 citation statements)

References 14 publications

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“…Although reports of extrapelvic symptoms in IC/BPS cases 1,2 and an association with other functional pain syndromes such as IBS and fibromyalgia are not new, 3–5 to our knowledge the possibility that somatization disorder presents in a classic PSPS pattern has not previously been considered in the UCPPS literature. We thought that this possibility should be further investigated in a subset of patients with complaints of numerous extrapelvic symptoms.…”

Section: Discussionmentioning

confidence: 93%

“…This may explain why extrapelvic symptoms are more prevalent among female patients with IC/BPS in previous studies. 1,2 Patients with IC/BPS may be characterized into 3 subgroups, including those with 1) bladder symptoms only, 2) pelvic symptoms and 3) multiple symptoms of other organ systems, eg fibromyalgia and IBS. 21 Although we did not specifically test this hypothesis in this study, our results raise the possibility that in a subset of patients with UCPPS, eg those with multiple symptoms of other organ systems, somatization disorder may be one of the common processes that help explain the association between UCPPS and other functional syndromes.…”

Section: Discussionmentioning

confidence: 99%

“…These extrapelvic symptoms may be painful or nonpainful, eg numbness, dizziness or palpitation. 1,2 Recent studies showed that IC/BPS may be associated with other functional syndromes, such as IBS, fibromyalgia or vulvodynia. 3–5 The pathophysiology behind this association is poorly understood.…”

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confidence: 99%

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Polysymptomatic, Polysyndromic Presentation of Patients With Urological Chronic Pelvic Pain Syndrome

et al. 2012

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Purpose Somatization disorder has been described in several comorbid functional syndromes of urological chronic pelvic pain syndrome, such as irritable bowel syndrome. We investigated whether a subset of patients with urological chronic pelvic pain syndrome may have the polysymptomatic, polysyndromic presentation pattern that is common in somatization disorder. Materials and Methods A total of 70 male and female patients with urological chronic pelvic pain syndrome and 35 age matched controls without the syndrome completed a 59-item symptom checklist to assess the classic polysymptomatic, polysyndromic symptom pattern. The 2 operational tools used were the Perley-Guze derived symptom checklist and the somatic symptom algorithm used for Diagnostic and Statistical Manual, 4th Edition, Text Revision somatization disorder criteria. Results Female patients with urological chronic pelvic pain syndrome (interstitial cystitis/bladder pain syndrome) reported significantly more nonpain symptoms and pain symptoms outside the pelvis than control female urology patients (p = 0.0016 and 0.0018, respectively). Female patients with urological chronic pelvic pain syndrome were more likely to endorse a polysymptomatic, polysyndromic symptom pattern than female controls (27% vs 0%, p = 0.0071). In contrast, male patients with urological chronic pelvic pain syndrome (interstitial cystitis/bladder pain syndrome and/or chronic prostatitis/chronic pelvic pain syndrome) did not report more extrapelvic pain than male controls (p = 0.89). Male patients with urological chronic pelvic pain syndrome were not more likely than male controls to have a polysymptomatic, polysyndromic symptom pattern. Conclusions A subset of female patients with urological chronic pelvic pain syndrome endorses numerous extrapelvic symptoms across multiple organ systems. The checklist may be valuable to assess patients for this polysymptomatic, polysyndromic symptom pattern, which is common in somatization disorder. Recognizing this polysymptomatic, polysyndromic presentation will prompt clinicians to investigate further to determine whether somatization disorder may be an underlying diagnosis in a small subset of patients with urological chronic pelvic pain syndrome who complain of numerous extrapelvic symptoms.

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Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 99%

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Polysymptomatic, Polysyndromic Presentation of Patients With Urological Chronic Pelvic Pain Syndrome

et al. 2012

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“…There is also an association between IC/BPS, CP/CPPS and chronic overlapping pain syndromes (COPC) such as irritable bowel syndrome, fibromyalgia, and chronic fatigue syndrome 1–3 with some studies reporting systemic (e.g., poly-symptomatic, poly-syndromic) symptom presentation. 4, 5 It has been hypothesized that patients with localized pelvic pain might represent a different phenotype than those with more widespread systemic pain. 6, 7 However to date, very few studies have characterized the location of body pain among men and women with IC/BPS or CP/CPPS.…”

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confidence: 99%

Characterization of Whole Body Pain in Urological Chronic Pelvic Pain Syndrome at Baseline: A MAPP Research Network Study

et al. 2017

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Purpose We characterized the location and spatial distribution of whole body pain among patients with urologic chronic pelvic pain syndrome (UCPPS) using a body map; and compared the severity of urinary symptoms, pelvic pain, non-pelvic pain, and psychosocial health among patients with different pain patterns. Methods 233 women and 191 men with UCPPS enrolled in a multi-center, one-year observational study completed a battery of baseline measures, including a body map describing the location of pain during the past week. Participants were categorized as having “pelvic pain only” if they reported pain in the abdomen and pelvis only. Participants who reported pain beyond the pelvis were further divided into two sub-groups based on the number of broader body regions affected by pain: an “intermediate” group (1–2 additional regions outside the pelvis) and a “widespread pain” group (3–7 additional regions). Results Of the 424 enrolled patients 25% reported pelvic pain only, and 75% reported pain beyond the pelvis of which 38% reported widespread pain. Participants with greater number of pain locations had greater non-pelvic pain severity (p<0.0001), sleep disturbance (p=0.035), depression (p=0.005), anxiety (p=0.011), psychological stress (p=0.005), negative affect scores (p=0.0004), and worse quality of life (p≤0.021). No difference in pelvic pain and urinary symptom severity were observed by increasing pain distribution. Conclusions Three-quarters of men and women with UCPPS reported pain outside the pelvis. Widespread pain was associated with greater severity of non-pelvic pain symptoms, poorer psychosocial health and worse quality of life, but not worse pelvic pain or urinary symptoms.

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“…These extra-pelvic symptoms may be painful (e.g., abdominal pain) or non-painful (e.g., numbness, dizziness, palpitation). 1, 2 We have previously shown that about one out of four UCPPS patients reported numerous somatic symptoms in a classic “poly-symptomatic, poly-syndromic” (PSPS) pattern of presentation. 3 The defining features of PSPS are that patients complain of numerous symptoms that are also widely distributed across multiple organ systems.…”

Section: Introductionmentioning

confidence: 99%

Urological Symptoms in a Subset of Patients with Urological Chronic Pelvic Pain Syndrome and a Polysymptomatic, Polysyndromic Pattern of Presentation

et al. 2014

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Purpose To characterize the urologic symptoms of a subset of urologic chronic pelvic pain syndrome (UCPPS) patients who have both a high somatic symptom burden and a wide symptom distribution fitting a “poly-symptomatic, poly-syndromic” (PSPS) pattern of presentation. Materials and Methods 81 UCPPS patients enrolled in the NIDDK MAPP Research Network Study at the Washington University in St. Louis and the University of Alabama at Birmingham sites completed a symptom questionnaire to assess their somatic symptom burden and its distribution, the Genitourinary Pain Index (GUPI) to assess their UCPPS symptoms and impact on quality of life, and self-reported treatment-seeking behaviors for their UCPPS symptoms. The PSPS symptom pattern was defined as self-report of numerous painful and non-painful somatic symptoms across many organ systems and symptom categories on the PSPS questionnaire. Results UCPPS patients with the PSPS pattern reported more severe genitourinary pain on a Likert scale, more frequent pain in the past week, and more widespread distribution of the pain in the genital and pelvic areas compared to UCPPS patients without PSPS. PSPS patients also had significantly higher scores on the pain subscale, quality of life subscale (worse), and the total scores on the GUPI questionnaire than patients without PSPS. Patients with the PSPS pattern reported significantly more treatment-seeking behaviors than other patients. Conclusion The PSPS pattern might be an important phenotypic factor to assess in the evaluation of UCPPS with clinical and research implications. This may be a distinct clinical subgroup among UCPPS patients.

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Nonbladder Related Symptoms in Patients With Interstitial Cystitis

Cited by 66 publications

References 14 publications

Polysymptomatic, Polysyndromic Presentation of Patients With Urological Chronic Pelvic Pain Syndrome

Polysymptomatic, Polysyndromic Presentation of Patients With Urological Chronic Pelvic Pain Syndrome

Characterization of Whole Body Pain in Urological Chronic Pelvic Pain Syndrome at Baseline: A MAPP Research Network Study

Urological Symptoms in a Subset of Patients with Urological Chronic Pelvic Pain Syndrome and a Polysymptomatic, Polysyndromic Pattern of Presentation

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