Nonbacterial thrombotic endocarditis

Campos, I; Marques, Ana Rita; Sousa, Luciana; Fonseca, Sara; Oliveira, Cátia; Vieira, Catarina; Apolinário, Isabel; Brandão, Ilídio

doi:10.1016/j.repce.2019.09.002

Cited by 2 publications

(2 citation statements)

References 13 publications

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“…In the case of other autoimmune diseases, sterile thrombotic endocardial vegetations have been described also in patients with rheumatoid arthritis [ 38 , 39 , 40 ], inflammatory myositis [ 41 ], systemic sclerosis [ 42 , 43 ], Behçet’s disease [ 44 ], Crohn’s disease [ 45 , 46 , 47 ], and vasculitis, particularly with anti-neutrophil cytoplasmic antibodies (ANCA) [ 48 , 49 , 50 , 51 ] and giant-cell arteritis [ 52 , 53 ] ( Table 1 ).…”

Section: Pathogenesis and Associated Conditionsmentioning

confidence: 99%

Diagnostic Work-Up in Patients with Nonbacterial Thrombotic Endocarditis

Tonutti,

Scarfò,

La Canna

et al. 2023

JCM

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Nonbacterial thrombotic endocarditis (NBTE) is a form of endocarditis that occurs in patients with predisposing conditions, including malignancies, autoimmune diseases (particularly antiphospholipid antibody syndrome, which accounts for the majority of lupus-associated cases), and coagulation disturbances for which the correlation with classical determinants is unclear. The condition is commonly referred to as “marantic”, “verrucous”, or Libman–Sacks endocarditis, although these are not synonymous, representing clinical–pathological nuances. The clinical presentation of NBTE involves embolic events, while local valvular complications, generally regurgitation, are typically less frequent and milder compared to infective forms of endocarditis. In the past, the diagnosis of NBTE relied on post mortem examinations, while at present, the diagnosis is primarily based on echocardiography, with the priority of excluding infective endocarditis through comprehensive microbiological and serological tests. As in other forms of endocarditis, besides pathology, transesophageal echocardiography remains the diagnostic standard, while other imaging techniques hold promise as adjunctive tools for early diagnosis and differentiation from infective vegetations. These include cardiac MRI and 18FDG-PET/CT, which already represents a major diagnostic criterion of infective endocarditis in specific settings. We will herein provide a comprehensive review of the current knowledge on the clinics and therapeutics of NBTE, with a specific focus on the diagnostic tools.

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Section: Pathogenesis and Associated Conditionsmentioning

confidence: 99%

Diagnostic Work-Up in Patients with Nonbacterial Thrombotic Endocarditis

Tonutti,

Scarfò,

La Canna

et al. 2023

JCM

View full text Add to dashboard Cite

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“…51 Prior cases of NBTE have been reported in the setting of long-standing RA. [52][53][54][55] The etiology of endocarditis in the setting of RA is incompletely understood; however, it is believed to be immune-mediated and is driven by antibody-initiated damage of the endothelium with inflammatory cell infiltration. Animal models suggest the role of CD4+ T cells and macrophages in the disease process.…”

Section: Pericarditis Treatmentmentioning

confidence: 99%

Cardiovascular Manifestations in Rheumatoid Arthritis

Sanghavi

Ingressia

Korem

et al. 2022

Cardiology in Review

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Rheumatoid arthritis (RA) is a systemic inflammatory disorder that characteristically affects the joints. RA has extra-articular manifestations that can impact multiple organ systems including the heart, lungs, eyes, skin, and brain. Cardiovascular involvement is a leading cause of mortality in RA. Cardiovascular manifestations of RA include accelerated atherosclerosis, heart failure, pericarditis, myocarditis, endocarditis, rheumatoid nodules, and amyloidosis. Inflammation is an important mediator of endothelial dysfunction and is a key driver of cardiovascular risk and complications in patients with RA. Prompt identification of cardiac pathologies in patients with RA is essential for appropriate management and treatment. Choosing the most appropriate treatment regimen is based on individual patient factors. In this article, we provide a comprehensive review of the epidemiology, pathophysiology, clinical manifestations, diagnosis, and medical management of cardiovascular manifestations of RA. We also discuss the relationship between anti-rheumatic medications, specifically non-steroidal anti-inflammatory drugs, corticosteroids, methotrexate, statins, tumor necrosis factor inhibitors, interleukin-6 inhibitors, Janus kinase inhibitors, and cardiovascular disease.

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Nonbacterial thrombotic endocarditis

Cited by 2 publications

References 13 publications

Diagnostic Work-Up in Patients with Nonbacterial Thrombotic Endocarditis

Diagnostic Work-Up in Patients with Nonbacterial Thrombotic Endocarditis

Cardiovascular Manifestations in Rheumatoid Arthritis

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