Nonbacterial thrombotic endocarditis in patients with malignant neoplastic diseases

Rosen, Peter; Armstrong, Donald

doi:10.1016/0002-9343(73)90079-x

Cited by 130 publications

(42 citation statements)

References 9 publications

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“…2 Not surprisingly, these small friable vegetations frequently embolize, involving different territories, especially the brain. 3 Pulmonary embolism has been documented in up to 50% of patients with NBTE, due to either embolization of right-sided vegetations or, as in the present case, facilitated by a thrombophilic environment. Exceptionally, NBTE verrucous lesions may become infected, as might possibly be the case in the present patient's smaller vegetation.…”

Section: Disclosuressupporting

confidence: 52%

Infected Marantic Endocarditis With Leukemoid Reaction

Sánchez-Enrique

Vilacosta

Moreno

et al. 2014

Circ J

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Section: Disclosuressupporting

confidence: 52%

Infected Marantic Endocarditis With Leukemoid Reaction

Sánchez-Enrique

Vilacosta

Moreno

et al. 2014

Circ J

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“…Cardiac murmurs are infrequently noted [28,29]. When present, these murmurs are nonspecific soft systolic murmurs located at the left lower sternal border.…”

Section: Clinical Manifestation and Diagnosismentioning

confidence: 99%

Nonbacterial Thrombotic Endocarditis in Cancer Patients: Pathogenesis, Diagnosis, and Treatment

2007

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LEARNING OBJECTIVES1. Enumerate procoagulant factors present in malignancy and the risk for thromboembolic events.2. Describe the morbidity associated with nonbacterial thrombotic endocarditis.3. List the recommended evaluations and treatments for nonbacterial thrombotic endocarditis.Access and take the CME test online and receive 1 AMA PRA Category 1 Credit ™ at CME.TheOncologist.com CME CME ABSTRACTThrombophilia is a well-described consequence of cancer and its treatment. The pathogenesis of this phenomenon is complex and multifactorial. Nonbacterial thrombotic endocarditis (NBTE) is a serious and potentially underdiagnosed manifestation of this prothrombotic state that can cause substantial morbidity in affected patients, most notably recurrent or multiple ischemic cerebrovascular strokes. Diagnosis of NBTE requires a high degree of clinical suspicion as well as the judicious use of two-dimensional echocardiography to document the presence of valvular thrombi. In the absence of contraindications to therapy, treatment consists of systemic anticoagulation, which may ameliorate symptoms and prevent further thromboembolic episodes, as well as control of the underlying malignancy whenever possible. The Oncologist 2007;12:518 -523 Disclosure of potential conflicts of interest is found at the end of this article.

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“…In contrast, NBTE is frequently asymptomatic and requires a high index of clinical suspicion. Since a definitive diagnosis can only be made by pathological examination, this is usually an autopsy finding [5]. …”

Section: Discussionmentioning

confidence: 99%

Nonbacterial Thrombotic Endocarditis Presenting with Leg Pain and a Left Atrial Mass Lesion

et al. 2018

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Systemic lupus erythematosus (SLE) is a major cause of nonbacterial thrombotic endocarditis (NBTE) associated with intracardiac sterile vegetations. It is rare for vegetations to present as an atrial tumor. This report describes a 48-year-old female with SLE and antiphospholipid syndrome complicated by recurrent thrombosis on anticoagulation. A large left atrial mass lesion was detected on echocardiography during a work-up for leg burning. Infective endocarditis could not be confirmed, and hence left atrial mass lesion was the most likely diagnosis. The patient was managed surgically and the pathology report revealed fibrin networks in a pattern similar to that of thrombosis, characteristic of NBTE.

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Nonbacterial thrombotic endocarditis in patients with malignant neoplastic diseases

Cited by 130 publications

References 9 publications

Infected Marantic Endocarditis With Leukemoid Reaction

Infected Marantic Endocarditis With Leukemoid Reaction

Nonbacterial Thrombotic Endocarditis in Cancer Patients: Pathogenesis, Diagnosis, and Treatment

Nonbacterial Thrombotic Endocarditis Presenting with Leg Pain and a Left Atrial Mass Lesion

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