Nonbacterial Thrombotic Endocarditis in a Child With Non-Hodgkin’s Lymphoma

Ali, Norliza; Konstantinov, Igor E.; Heath, John A.; Bhagwat, Krishna; Cheung, Michael

doi:10.1007/s00246-012-0230-y

Cited by 6 publications

(3 citation statements)

References 7 publications

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“…Among 829 searched studies, 121 studies [ 19 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 ...…”

Section: Resultsunclassified

Lung Cancer as a Leading Cause among Paraneoplastic Non-Bacterial Thrombotic Endocarditis: A Meta-Analysis of Individual Patients’ Data

Rahouma

Khairallah

Dabsha

et al. 2023

Cancers

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Hypercoagulability is strongly associated with cancer and may result in non-bacterial thrombotic endocarditis (NBTE). The aim of our meta-analysis was to explore the demographics and characteristics of this condition in cancer. Databases were systematically searched. The outcomes were to identify the annual trend in premortem diagnosis among the entire cohort and different subgroups and to identify differences in characteristics and survival in the considered population. A total of 121 studies with 144 patients were included. The proportion of marantic endocarditis associated with lung cancer was 0.29 (95% CI, 0.21–0.37; p < 0.001), that associated with pancreatic cancer was 0.19 (95% CI, 0.13–0.27; p < 0.001), that associated with advanced cancer stage (metastasis) was 0.69 (95% CI, 0.61–0.76; p < 0.001), and that associated with adenocarcinoma was 0.65 (95% CI, 0.56–0.72; p < 0.001). Median and 6-month overall survival (OS) were 1.3 months and 32.3%, respectively, with 6-month OS of 20.8% vs. 37.0% in lung vs. other cancers, respectively (p = 0.06) and 42.9% vs. 31.1% among those who underwent intervention vs. those who did not (p = 0.07). Cases discovered in recent years had better survival (HR = 0.98 (95% CI, 0.96–0.99; p = 0.003). While cancer-associated NBTE is a rare entity, lung cancers were the most common tumor site and are frequently associated with more advanced and metastatic cancer stages. The prognosis is dismal, especially among lung cancers.

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Section: Resultsunclassified

Lung Cancer as a Leading Cause among Paraneoplastic Non-Bacterial Thrombotic Endocarditis: A Meta-Analysis of Individual Patients’ Data

Rahouma

Khairallah

Dabsha

et al. 2023

Cancers

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“…Hematologic malignancies are extremely rare among the reported cancer types associated with NBTE. To date, only two of the published cases are diagnosed as non‐Hodgkin lymphoma 2,3 . Interestingly, in a previous review containing 2381 autopsies, 4 BMT was found to impose higher risks of NBTE on the general population and even the patients carrying bone marrow transplantation (BMT) candidate diseases.…”

Section: Figurementioning

confidence: 99%

“…To date, only two of the published cases are diagnosed as non-Hodgkin lymphoma. 2,3 Interestingly, in a previous review containing 2381 autopsies, 4 BMT was found to impose higher risks of NBTE on the general population and even the patients carrying bone marrow transplantation (BMT) candidate diseases. However, the mechanistic association between BMT and NBTE remained unclear.…”

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confidence: 99%