Nonanimal Stabilized Hyaluronic Acid for Lip Augmentation and Facial Rhytid Ablation

Bosniak, Stephen; Cantisano-Zilkha, Marian; Glavas, Ioannis P.

doi:10.1001/archfaci.6.6.379

Cited by 38 publications

(26 citation statements)

References 22 publications

(19 reference statements)

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“…The high subject satisfaction rates for Volbella™ eclipsed those seen for Restylane ® in a Brazilian study6 of 1446 consecutive patients treated in up to four areas of the face. Of the 685 patients who received Restylane ® for lip augmentation, 77.8% were satisfied at 3 months (38.3% very satisfied, 39.6% satisfied, and 22.2% unsatisfied), 50.8% were satisfied at 6 months (8.0% very satisfied, 42.8% satisfied, and 49.2% unsatisfied), and 36.6% were satisfied at 9 months (4.7% very satisfied, 32.0% satisfied, and 63.4% unsatisfied).…”

Section: Discussionmentioning

confidence: 99%

Juvéderm® Volbella™ in the perioral area: a 12-month prospective, multicenter, open-label study

Eccleston¹,

Murphy²

2012

CCID

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Background:Hyaluronic acid dermal fillers are frequently used for lip augmentation, and a new filler has been developed with characteristics especially suited for the lips.Methods:Four European sites treated 60 subjects with Juvéderm® Volbella™ injectable gel in the perioral area, and subjects returned to the clinic at 1, 3, 6, 9, and 12 months for follow-up. The primary effectiveness endpoint established a priori was a Month 3 responder rate on the 4-point Lip Fullness Scale (LFS) of ≥40% and statistically > 0%, where responders improved ≥ 1 point from baseline on the investigator’s assessment of LFS. At follow-up, subjects assessed lip fullness goal achievement, the look and feel of their lips, and their satisfaction with the effects of treatment.Results:The Month 3 LFS responder rate was 93.2% (P < 0.0001), so the primary endpoint was met, and clinical effectiveness was demonstrated. The responder rate over time showed that 78.0% of subjects still had improved lip fullness at Month 9 and 48.3% at Month 12. After treatment 98.3% of subjects reported that their lip fullness goal had been achieved, and this was maintained at 86.4% at Month 9 and 56.9% at Month 12. At Month 1, 81.0% of subjects reported that their lips felt smooth, and 91.4% reported that their lips looked natural (scores of 7–10 on an 11-point scale, where 0 was an unfavorable outcome and 10 was a favorable outcome). Similarly, 96.6% of subjects reported being satisfied (scores between 7 and 10 on an 11-point scale where 0 = very dissatisfied, 10 = very satisfied) at Month 1, and by Month 12 more than 80% of subjects were still satisfied. There were no severe adverse events related to treatment.Conclusion:Juvéderm® Volbella™ injectable gel is well tolerated and has been demonstrated to provide a smooth and natural improvement in lip fullness that lasts for up to 1 year.

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Section: Discussionmentioning

confidence: 99%

Juvéderm® Volbella™ in the perioral area: a 12-month prospective, multicenter, open-label study

Eccleston¹,

Murphy²

2012

CCID

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“…Several open-label reports or randomised, no treatment – controlled studies, have described the effectiveness of HA in lip augmentation. [ 13 14 15 16 ] However, there are different HA products on the market, and the process of development in the product is still continued.…”

Section: Introductionmentioning

confidence: 99%

Assessment of the efficacy and safety of hyaluronic acid gel injection in the restoration of fullness of the upper lips

Yazdanparast

Samadi

Hasanzadeh

et al. 2017

J Cutan Aesthet Surg

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Background and Aim:Lips have a significant role in face aesthetic perception, and lip augmentation is one of the most commonly requested aesthetic procedures. Non-permanent dermal fillers, such as hyaluronic acid (HA), are used for augmenting the lips. This article presents the results of Phase II, before – after designed study, assessing the safety and efficacy of a soft tissue HA filler, for upper lip augmentation.Materials and Methods:Investigators treated 10 healthy adult women 28–45 years old, using a single injection of Hyamax Kiss soft tissue HA filler (a product from Hyamed Laboratories, Switzerland) for upper lip augmentation. The primary efficacy endpoint was an increase in lip fullness at least one grade on Medicis Lip Fullness Scale at 2, 12 and 24 weeks post-treatment. Furthermore, the effectiveness and durability of filler were assessed using a 5-point Investigator's Global Assessment (IGA). Adverse events and volunteers' satisfaction were reported using visual analog scale.Results:Response to treatment (as defined above) after 2, 12 and 24 weeks were observed in 80%, 70% and 80% of patients, respectively. No statistical difference was found in response to treatment rate between follow-up visits (P = 0.83). The mean value of IGA score in weeks 2, 12 and 24 were 3.4 ± 0.96, 3.3 ± 0.67 and 3.3 ± 0.67, respectively. The study subjects were almost all satisfied with their lip improvement. Reported adverse effects were temporary and mostly mild in severity.Conclusion:Soft tissue HA filler tested in this study was well tolerated, efficient and durable when used for upper lip augmentation.

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“…Surgical options used alone or in combination with variable degrees of success include midface lift, tarsal strips, microfat grafting, suborbital malar (cheek) implants, and transconjunctival lower lid blepharoplasty with fat transposition or transfer, 6–10 but the patient must be willing to undergo a surgical procedure with the associated risks and recuperative time. Alternatively, filling agents may be used but with extreme caution in this delicate and highly vascularized area 11–15 . A thorough understanding of periocular anatomy must precede using any injectable agent in the periorbital region.…”

Section: Discussionmentioning

confidence: 99%

Definition of the tear trough and the tear trough rating scale

Sadick

Bosniak

Cantisano-Zilkha³

et al. 2007

J of Cosmetic Dermatology

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Nonanimal Stabilized Hyaluronic Acid for Lip Augmentation and Facial Rhytid Ablation

Cited by 38 publications

References 22 publications

Juvéderm® Volbella™ in the perioral area: a 12-month prospective, multicenter, open-label study

Juvéderm® Volbella™ in the perioral area: a 12-month prospective, multicenter, open-label study

Assessment of the efficacy and safety of hyaluronic acid gel injection in the restoration of fullness of the upper lips

Definition of the tear trough and the tear trough rating scale

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Nonanimal Stabilized Hyaluronic Acid for Lip Augmentation and Facial Rhytid Ablation

Cited by 38 publications

References 22 publications

Juv&eacute;derm&reg; Volbella&trade; in the perioral area: a 12-month prospective, multicenter, open-label study

Juv&eacute;derm&reg; Volbella&trade; in the perioral area: a 12-month prospective, multicenter, open-label study

Assessment of the efficacy and safety of hyaluronic acid gel injection in the restoration of fullness of the upper lips

Definition of the tear trough and the tear trough rating scale

Contact Info

Product

Resources

About

Juvéderm® Volbella™ in the perioral area: a 12-month prospective, multicenter, open-label study

Juvéderm® Volbella™ in the perioral area: a 12-month prospective, multicenter, open-label study