Nonallergic rhinitis with eosinophilia (NARES syndrome) *1Clinical and immunologic presentation

Jacobs, Robert L.; Freedman, Peter M.; Boswell, R N

doi:10.1016/0091-6749(81)90019-1

Cited by 158 publications

(69 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The definite difference between the two groups, however, indicates that the phenomenon we are describing is not ubiquitous and that it might well represent a form of hyperreactivity ofthe nasal mucosa. It has been reported that conditions such as vasomotor rhinitis, nasal mastocytosis, and nonallergic rhinitis with eosinophilia are associated with nasal sensitivity to climatic changes (35)(36)(37). It has also been reported that when volunteers breathed or hyperventilated cold air through their nose, nasal irritation and increased nasal airway resistance occurred (38)(39)(40).…”

Section: Discussionmentioning

confidence: 99%

Nasal challenge with cold, dry air results in release of inflammatory mediators. Possible mast cell involvement.

et al. 1985

View full text Add to dashboard Cite

The purpose of our study was to assess the effect of cold, dry air (CDA) on the nasal mucosa of selected individuals in relation to the release of inflammatory mediators associated with mast cells. 12 subjects with a history of nasal symptoms of rhinorrhea and congestion upon cold or dry environmental exposure were challenged by nasal breathing of CDA and warm, moist air (WMA). Each subject was tested on two occasions with the order of the challenges reversed. Symptom scores were recorded, and the levels of histamine, prostaglandin (PG) D2, kinins, and 1H1-N-a-tosyl-L-arginine methyl ester (TAME)-esterase activity in nasal lavage fluids were measured.CDA caused a significant increase in mediator levels and in symptom scores as compared to baseline or to WMA. No significant increase in symptom scores or mediators was noted after WMA challenge, with the exception of a marginal increase in kinins. The response to CDA was similar, regardless of challenge order. Changes in mediators correlated with one another, and symptom scores correlated significantly with the levels of histamine, kinins, and PGD2. Five subjects without a history of nasal symptoms on cold air exposure had no change in mediators or symptom scores after CDA or WMA challenge. We conclude that CDA causes the release of inflammatory mediators possibly associated with mast cells and speculate that such a mechanism may be involved in the bronchospasm induced by CDA in asthmatics.

show abstract

Section: Discussionmentioning

confidence: 99%

Nasal challenge with cold, dry air results in release of inflammatory mediators. Possible mast cell involvement.

et al. 1985

View full text Add to dashboard Cite

show abstract

“…Nonallergic rhinitis with eosinophilia syndrome was defined in the early 1980s (199)(200)(201). Although it probably does not represent a disease entity on its own, it may be regarded as a subgroup of idiopathic rhinitis, characterized by the presence of nasal eosinophilia and PER symptoms of sneezing, itching, rhinorrhoea and occasionally a loss of sense of smell in the absence of demonstrable allergy.…”

Section: Nares and Eosinophilic Rhinitismentioning

confidence: 99%

Allergic Rhinitis and its Impact on Asthma (ARIA) 2008*

Bousquet¹,

Khaltaev²,

Cruz³

et al. 2008

Allergy

3,801

1,761

View full text Add to dashboard Cite

“…Over the years, several studies on nasal cytology helped to clarify some of the pathophysiological mechanisms underlying IgE-mediated rhinitis, as well as the identification of new classified entities such as non-allergic rhinitis with eosinophilia (nonallergic rhinitis with eosinophils , NARES), with mast cells (non-allergic rhinitis with mast cell, NARMA), neutrophilic forms (non-allergic rhinitis with neutrophils, NARNE) and, finally, the eosinophil-mast cell (non-allergic rhinitis with eosinophils and mast cell, NARESMA) [8][9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Nasal cytology: the “infectious spot”, an expression of a morphological-chromatic biofilm

Gelardi

Passalacqua

Fiorella

et al. 2011

Eur J Clin Microbiol Infect Dis

View full text Add to dashboard Cite

The purpose of study was to describe some "morphological-chromatic" patterns (i.e.spots of cyan colour) identified during the study of nasal cytology in patients with both bacterial and fungal infectious rhinological disorders. These peculiar aspects strongly suggest the presence of a microscopic biofilm. We retrospectively examined 1,410 nasal cytology specimens from subjects who underwent clinical-instrumental investigations (history, ENT visit, nasal endoscopy and nasal cytology) from January to August 2010. The control samples were represented by 30 subjects not suffering from infectious rhinological diseases. The presence of particular spots of "Cyan", was found in colour in 107/1,410 rhinocytograms (7.6 %) within which bacterial colonies and/or fungal spores were found.We called these colored spot formations "Infectious Spots" (IS). 2The positivity to PAS staining confirmed the polysaccharide nature of the colored spots and allowed us to relate them to biofilms. This study demonstrates, for the first time, that nasal cytology performed by optical microscope can play an important role in detecting biofilms.

show abstract

Nonallergic rhinitis with eosinophilia (NARES syndrome) *1Clinical and immunologic presentation

Cited by 158 publications

References 38 publications

Nasal challenge with cold, dry air results in release of inflammatory mediators. Possible mast cell involvement.

Nasal challenge with cold, dry air results in release of inflammatory mediators. Possible mast cell involvement.

Allergic Rhinitis and its Impact on Asthma (ARIA) 2008*

Nasal cytology: the “infectious spot”, an expression of a morphological-chromatic biofilm

Contact Info

Product

Resources

About