Nonalcoholic Steatohepatitis Score is an Independent Predictor of Right Ventricular Dysfunction in Patients with Nonalcoholic Fatty Liver Disease

Sünbül, Murat; Kıvrak, Tarık; Durmuş, Erdal; Akın, Hakan; Aydın, Yücel; Ergelen, Rabia; Yılmaz, Yusuf; Ağırbaşlı, Mehmet

doi:10.1111/1755-5922.12145

Cited by 24 publications

(12 citation statements)

References 32 publications

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“…Rimbas et al agree with our results regarding RV systolic function in cirrhotic patients [11]. On the other hand, Sunbul et al found significantly lower TAPSE and s’ in patients with non-alcoholic fatty liver disease [16].…”

Section: Discussionsupporting

confidence: 90%

“…The same results were obtained for the whole RV and RV-free wall. Reduced RV strain was also found in other investigations that included patients with cirrhosis or even patients with non-alcoholic fatty liver disease [11,15,16]. However, this is the first study that showed layer-specific changes in the RV strain in patients with end-stage liver cirrhosis.…”

Section: Discussionsupporting

confidence: 80%

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Right Heart Remodeling in Patients with End-Stage Alcoholic Liver Cirrhosis: Speckle Tracking Point of View

Zhang

Braun

Koeckritz

et al. 2019

JCM

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Background: Data regarding cardiac remodeling in patients with alcoholic liver cirrhosis are scarce. We sought to investigate right atrial (RA) and right ventricular (RV) structure, function, and mechanics in patients with alcoholic liver cirrhosis. Methods: This retrospective cross-sectional investigation included 67 end-stage cirrhotic patients, who were referred for evaluation for liver transplantation and 36 healthy controls. All participants underwent echocardiographic examination including strain analysis, which was performed offline. Results: RV basal diameter and RV thickness were significantly higher in patients with cirrhosis. Conventional parameters of the RV systolic function were similar between the observed groups. Global, endocardial, and epicardial RV longitudinal strains were significantly lower in patients with cirrhosis. Active RA function was significantly higher in cirrhotic patients than in controls. The RA reservoir and conduit strains were significantly lower in cirrhotic patients, while there was no difference in the RA contractile strain. Early diastolic and systolic RA strain rates were significantly lower in cirrhotic patients than in controls, whereas there was no difference in the RA late diastolic strain rate between the two groups. Transaminases and bilirubin correlated negatively with RV global longitudinal strain and RV-free wall strain in patients with end-stage liver cirrhosis. The Model for End-stage Liver Disease (MELD) score, predictor of 3-month mortality, correlated with parameters of RV structure and systolic function, and RA active function in patients with end-stage liver cirrhosis. Conclusions: RA and RV remodeling is present in patients with end-stage liver cirrhosis even though RV systolic function is preserved. Liver enzymes, bilirubin, and the MELD score correlated with RV and RA remodeling.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 80%

Right Heart Remodeling in Patients with End-Stage Alcoholic Liver Cirrhosis: Speckle Tracking Point of View

Zhang

Braun

Koeckritz

et al. 2019

JCM

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“…Right ventricular function is also found to be impaired in patients with NA-FLD. In those patients, NASH score plays role in predicting right ventricular function (45).…”

Section: Cardiovascular Disordersmentioning

confidence: 99%

Non-alcoholic fatty liver disease: A growing public health problem in Turkey

Kaya

Yılmaz

2019

Turk J Gastroenterol

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Non-alcoholic fatty liver disease (NAFLD) is histologically classified as either non-alcoholic fatty liver or non-alcoholic steatohepatitis (NASH). NASH is the progressive subtype of NAFLD. Individuals with NASH are at significant risk of developing hepatic fibrosis, cirrhosis, hepatocellular carcinoma, and liver-related and all-cause mortality. NAFLD is closely associated with obesity, type 2 diabetes mellitus (T2DM), metabolic syndrome, and cardiovascular events. Its prevalence is estimated to be above 30% in Turkey; and recent studies confirm this estimate. According to these studies, the prevalence of NAFLD in Turkey is between 48.3% and 60.1%. Currently, Turkey can be considered a risky region in terms of NAFLD burden as it is the most obese country in Europe with an obesity prevalence of 32.1% according to the 2016 World Health Organization data. Moreover, along with the increasing prevalence of obesity and T2DM in Turkey, the burden of NAFLD is estimated to increase in the upcoming decade. Despite the growing burden, we lack well-designed systemic studies that investigate NAFLD and its marked histological severity. In this review, we present studies on the burden of NAFLD and NASH, the natural history of NAFLD, and its association with other systemic diseases conducted with Turkish populations.

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“…In addition, patients who developed hepatic steatosis showed an increase in CIMT whereas those without did not see a significant change 47 . In regard to cardiac dysfunction risk, patients with NAFLD, particularly those with non-alcoholic steatohepatitis, have worsened right ventricular function compared with non-NAFLD counterparts 49 . Coupled with type 2 diabetes, the risk for left ventricular dysfunction is also higher: patients with both T2DM and NAFLD have greater left ventricular diastolic dysfunction than those with T2DM alone 50 .…”

Section: Non-alcoholic Fatty Liver Disease As a Risk Factor Of Cardiomentioning

confidence: 99%

The role of NAFLD in cardiometabolic disease: an update

2018

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Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease in the world, yet the complex pathogenesis remains to be fully elucidated. The prevalence of NAFLD has risen precipitously in recent years and is now a leading indication for liver transplantation. New waitlist registrants with non-alcoholic steatohepatitis–induced cirrhosis increased by 170% from 2004 to 2013. In addition, patients with NAFLD are at increased risk of both cardiovascular disease and type II diabetes. In this update, recent studies contributing to the understanding of the place of NAFLD in cardiometabolic disease will be discussed.

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Nonalcoholic Steatohepatitis Score is an Independent Predictor of Right Ventricular Dysfunction in Patients with Nonalcoholic Fatty Liver Disease

Cited by 24 publications

References 32 publications

Right Heart Remodeling in Patients with End-Stage Alcoholic Liver Cirrhosis: Speckle Tracking Point of View

Right Heart Remodeling in Patients with End-Stage Alcoholic Liver Cirrhosis: Speckle Tracking Point of View

Non-alcoholic fatty liver disease: A growing public health problem in Turkey

The role of NAFLD in cardiometabolic disease: an update

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