Nonalcoholic fatty liver disease (NAFLD) in children

Sathya, P; Martin, Steven R.; Álvarez, Fernando

doi:10.1097/00008480-200210000-00006

Cited by 36 publications

(32 citation statements)

References 62 publications

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“…The presence of non-alcoholic fatty liver disease (NAFLD) was significantly higher in patients with dyslipidemia, as described previously [34], reflecting the association of NAFLD with the metabolic syndrome.…”

Section: Discussionsupporting

confidence: 66%

Frequency of Cardiovascular Risk Factors in Obese Children and Adolescents Referred to a Tertiary Care Center in Israel

Shalitin

Phillip

2008

Horm Res Paediatr

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Aims: To establish the frequency of dyslipidemia in obese Israeli children and adolescents and its association with other cardiovascular disease (CVD) risk factors. Methods: Files of 262 patients (5.1–18.8 years) with BMI >95th percentile for age and gender were reviewed for anthropometric and biochemical parameters of CVD risk. Dyslipidemia and hypertension were defined as cut-off point ≧95th percentile of healthy children. Results: Compared to patients with normal lipid profile, dyslipidemic patients (n = 71) had significantly higher prevalence of fatty liver (p < 0.001), higher percent body fat (males, p = 0.044), and higher C-reactive protein (females, p = 0.001). There was no significant difference in age, BMI-SDS, or familial CVD-related disorders. The hypertensive patients (n = 137) were significantly older than the normotensive patients (p < 0.001), had higher percent body fat (p = 0.008), larger waist circumference (p < 0.001), and higher HOMA-IR (p < 0.001). There were no significant between-group differences in BMI-SDS. The most significant factors associated with CVD risk were waist circumference and insulin level. Conclusions: Obese Israeli children have high rates of CVD risk factors, most of them unrelated to BMI-SDS or age. Therefore, we recommend screening for them in obese children with increased waist circumference of any age to detect those who require more intense interventions.

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Section: Discussionsupporting

confidence: 66%

Frequency of Cardiovascular Risk Factors in Obese Children and Adolescents Referred to a Tertiary Care Center in Israel

Shalitin

Phillip

2008

Horm Res Paediatr

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“…In the present study, the second third subjects of the obese group had elevated serum transaminase levels caused by suggesting that obese students should take blood examinations for screening of NAFLD. Moreover, nonalcoholic steatohepatitis (NASH), in which fatty change and inflammation of the liver occur in the absence of excess alcohol intake, is increasingly recognized in obese children (27,28). NASH can develop into liver cirrhosis and liver failure.…”

Section: Discussionmentioning

confidence: 99%

Brachial-ankle Pulse Wave Velocity in Japanese University Students

et al. 2005

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Objective Pulse wave velocity (PWV) correlates well with arterial distensibility and stiffness and is a useful non-invasive index to assess arteriosclerosis. The present study was conducted to evaluate the validity of noninvasive brachial-ankle PWV (baPWV) measurements in overweight young adults.Methods Three hundred and fifty-three students were voluntarily enrolled (mean age: 20±2, 93 women and 260 men). The subjects were divided into three groups: normal (18.5< = body mass index (BMI) <25 n=120), overweight (25< = BMI <30 n=164) and obese (BMI > = 30, n=69). The baPWV was measured using volume-plethymographic apparatus.Results Hypertension and hyperlipidemia were diagnosed in one-third of the subjects of the obese group and nonalcoholic fatty liver disease (NAFLD) was diagnosed in 64% of the obese group. The baPWV in male subjects was significantly higher in the obese group than in the overweight group and in the males with NAFLD than in those without NAFLD. The stepwise linear regression analysis showed that PWV was significantly associated with mean blood pressure (p<0.001) and -GTP (p=0.03).Conclusion Mean blood pressure was a powerful determination for baPWV in the university students. BaPWV may be useful to predict the initial stage of arteriosclerosis and conceivably NAFLD including nonalcoholic steatohepatitis (NASH) in obese young adults.

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“…Childhood NAFLD has become an important childhood liver disease [35][36][37]. It is likely to reach epidemic proportions in children in the next decade.…”

Section: Nafld and Nash In Childrenmentioning

confidence: 99%