Nonalcoholic fatty liver disease (NAFLD) from pathogenesis to treatment concepts in humans

Pafili, Kalliopi; Roden, Michael

doi:10.1016/j.molmet.2020.101122

Cited by 166 publications

(130 citation statements)

References 240 publications

Supporting

Mentioning

118

Contrasting

Unclassified

Order By: Relevance

“…Currently, a number of monotherapies have demonstrated clinical benefits to various degrees, but their efficacy in promoting both NASH resolution and fibrosis improvement is still relatively limited. 2 So far, whether combination therapy may potentially result in enhanced therapeutic efficacy against NASH is still largely unexplored.…”

mentioning

confidence: 99%

Combined ASBT Inhibitor and FGF15 Treatment Improves Therapeutic Efficacy in Experimental Nonalcoholic Steatohepatitis

Matye

Wang

Luo

et al. 2021

Cellular and Molecular Gastroenterology and Hepatology

View full text Add to dashboard Cite

show abstract

mentioning

confidence: 99%

Combined ASBT Inhibitor and FGF15 Treatment Improves Therapeutic Efficacy in Experimental Nonalcoholic Steatohepatitis

Matye

Wang

Luo

et al. 2021

Cellular and Molecular Gastroenterology and Hepatology

View full text Add to dashboard Cite

show abstract

“…Chronic UPR/ER stress contributes to the pathogenesis of HCC and disease development [149,154]. Multiple risk factors are commonly associated with carcinogenesis of HCC such as HBV/HCV viral infections, excessive alcoholic consumption, obesity and NAFLD [13][14][15][16][17]155]. However, the precise contribution of each of the factors to ER stress induction is not clear, and their importance to HCC may depend on ER stress duration, presence or absence of genetic factors, cross-talks with other pathogenic pathways, and liver disease stages.…”

Section: Discussionmentioning

confidence: 99%

Endoplasmic Reticulum Stress Signaling and the Pathogenesis of Hepatocarcinoma

Wei

Fang

2021

IJMS

View full text Add to dashboard Cite

Hepatocellular carcinoma (HCC), also known as hepatoma, is a primary malignancy of the liver and the third leading cause of cancer mortality globally. Although much attention has focused on HCC, its pathogenesis remains largely obscure. The endoplasmic reticulum (ER) is a cellular organelle important for regulating protein synthesis, folding, modification and trafficking, and lipid metabolism. ER stress occurs when ER homeostasis is disturbed by numerous environmental, physiological, and pathological challenges. In response to ER stress due to misfolded/unfolded protein accumulation, unfolded protein response (UPR) is activated to maintain ER function for cell survival or, in cases of excessively severe ER stress, initiation of apoptosis. The liver is especially susceptible to ER stress given its protein synthesis and detoxification functions. Experimental data suggest that ER stress and unfolded protein response are involved in HCC development, aggressiveness and response to treatment. Herein, we highlight recent findings and provide an overview of the evidence linking ER stress to the pathogenesis of HCC.

show abstract

“…Excessive caloric intake rich in saturated fats, refined carbohydrates and/or sugar-sweetened beverages, has been implicated in the development of NAFLD [26][27][28] to occur via increased HCL [3,26]. But diets containing saturated fat, not only promote hepatic triglyceride accumulation, but also favor gluconeogenesis, resulting from allosteric activation of pyruvate carboxylase flux and increased glycerol flux, and induce insulin resistance by lipid-mediated inhibition of insulin signaling [2].…”

Section: Discussionmentioning

confidence: 99%

Improving insulin sensitivity, liver steatosis and fibrosis in type 2 diabetes by a food-based digital education-assisted lifestyle intervention program: a feasibility study

et al. 2021

Self Cite

View full text Add to dashboard Cite

Purpose Recent trials demonstrated remission of type 2 diabetes and non-alcoholic fatty liver disease (NAFLD) following formula diet-induced weight loss. To improve the outreach for populations in need, many mobile health apps targeting weight loss have been developed with limited scientific evaluation of these apps. The present feasibility study investigated the effects of a novel approach incorporating a regular ‘whole food-based’ low-calorie diet combined with app-based digital education and behavioral change program on glucose metabolism and disease management. Methods Twenty-four individuals with type 2 diabetes followed this approach supported by weekly coaching calls for 12 weeks. Phenotyping included bioimpedance analysis, mixed-meal tolerance test, magnetic resonance spectroscopy and transient elastography for assessing liver fat content and liver stiffness. Results Over 12 weeks, participants reduced their body weight by 9% (97 ± 13 to 88 ± 12 kg), body mass index (BMI; 33 ± 5 to 29 ± 4 kg/m2), total fat mass (31 ± 10 to 27 ± 10%) (all p < 0.01) and liver fat by 50% alongside with decreased liver stiffness. Target HbA1c (< 6.5%) was achieved by 38% and resolution of NAFLD (liver fat content < 5.6%) was observed in 30% of the participants. Conclusion This novel approach combining digital education with a low-calorie diet results in effective improvements of body weight, glycemic control and NAFLD and could complement existing care for patients with type 2 diabetes. Trial registration NCT04509245

show abstract

Nonalcoholic fatty liver disease (NAFLD) from pathogenesis to treatment concepts in humans

Cited by 166 publications

References 240 publications

Combined ASBT Inhibitor and FGF15 Treatment Improves Therapeutic Efficacy in Experimental Nonalcoholic Steatohepatitis

Combined ASBT Inhibitor and FGF15 Treatment Improves Therapeutic Efficacy in Experimental Nonalcoholic Steatohepatitis

Endoplasmic Reticulum Stress Signaling and the Pathogenesis of Hepatocarcinoma

Improving insulin sensitivity, liver steatosis and fibrosis in type 2 diabetes by a food-based digital education-assisted lifestyle intervention program: a feasibility study

Contact Info

Product

Resources

About