Nonalcoholic Fatty Liver Disease Markers Are Associated with Insulin Resistance in Type 1 Diabetes

Bulum, Tomislav; Kolarić, Branko; Duvnjak, Lea; Duvnjak, Marko

doi:10.1007/s10620-011-1807-7

Cited by 27 publications

(15 citation statements)

References 53 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…33 Moreover, we have previously observed that insulin resistance, the most important antecedent of microalbuminuria, was independently associated with ALK in type 1 diabetes. 27 In multivariate logistic regression analysis, we found that ALK levels tend to be higher in patients with lower serum creatinine levels and in those with higher eGFR, which seems to be contradictory to the previous studies indicating that higher ALK levels are not associated with worsening of renal function. However, the levels of ALK were especially increased in hyperfiltrating subjects.…”

Section: Discussioncontrasting

confidence: 99%

“…2,26 Insulin resistance is the central pathophysiological phenomenon of metabolic syndrome, and it has been shown that NAFLD markers are associated with insulin resistance in type 1 diabetes and that insulin resistance contributes to the progression of nephropathy in type 1 diabetes. 27,28 It has been suggested that NAFLD may be involved in the pathogenesis of CKD through the systemic release of various proinflammatory and procoagulant mediators from steatotic liver including C-reactive protein (CRP), tumor necrosis factor-alfa (TNF-a), transforming growth factor-beta 1 (TGF-b1), plasminogen activator inhibitor 1 (PAI-1), interleukin-6, advanced glycated end-products, and other pro-inflammatory cytokines. 13 However, it has been shown that NAFLD is associated with an increased prevalence of CKD in type 1 diabetes independently of metabolic syndrome.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Alkaline phosphatase is independently associated with renal function in normoalbuminuric type 1 diabetic patients

et al. 2014

Self Cite

View full text Add to dashboard Cite

Nonalcoholic fatty liver disease (NAFLD) is associated with an increased prevalence of chronic kidney disease in patients with type 1 diabetes. The aim of this study was to explore the relationship between markers of NAFLD, namely concentrations of aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALK), g-glutamyltransferase (GGT), bilirubin, and renal function in type 1 diabetic patients. This study included 313 normoalbuminuric type 1 diabetic patients with estimated glomerular filtration rate (eGFR) 460 mL/min/1.73 m 2 , without clinical evidence of cirrhosis or other causes of chronic liver disease and before any interventions with statins, angiotensin-converting enzyme (ACE) inhibitors or angiotensin II receptor blockers. ALT, GGT, and bilirubin levels were significantly higher in subjects in the highest quartile of serum creatinine compared to those in lowest quartile (21 vs. 20 U/L, 18 vs. 14 U/L, and 14 vs. 10 mmol/L, respectively, for all p50.05). ALK levels were significantly higher in subjects in the highest quartile of urinary albumin excretion rate compared to those in lowest quartile (71 vs. 69 U/L, p ¼ 0.03), as well as in hyperfiltrating subjects compared to those with normal or mildly impaired eGFR (81 vs. 68 and 64 U/L, p50.001). In a multiple logistic regression model adjusted for age, sex, duration of diabetes, HbA1c, and body mass index (BMI), only ALK levels were significantly associated with disturbances in serum creatinine and eGFR in our subjects (p 0.007), with odds ratios of 0.98-1.02. NAFLD associated markers, particularly ALK, are associated with renal function in normoalbuminuric type 1 diabetic patients.

show abstract

Section: Discussioncontrasting

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Alkaline phosphatase is independently associated with renal function in normoalbuminuric type 1 diabetic patients

et al. 2014

Self Cite

View full text Add to dashboard Cite

show abstract

“…It is not possible to conclusively rule out an association between shift work and liver unhealthiness by our observations of relative young and healthy workers, since adverse effects of circadian disruption on liver health have been found in both animal (Filipski et al, 2009;Konturek et al, 2011) and human studies (Copertaro et al, 2008;Larsson et al, 2009;Ma et al, 2009;Nakamura et al, 1998) and have been supported by studies on gene expression (Szantoova et al, 2011). Determining the exact effects of RSW on liver health in the future may require longer monitoring and other surrogate markers, such as microRNA-122 (Arataki et al, 2013;Spaniel et al, 2013;Waidmann et al, 2012;Xing et al, 2013), aspartate aminotransferase, glutamyl transpeptidase, and bilirubin levels (Bulum et al, 2011). Besides conventional parameters, one can measure the body temperature and monitor the melatonin rhythm, to demonstrate the mismatch between central and peripheral rhythm among shift workers (Cermakian & Boivin, 2009).…”

Section: Discussionmentioning

confidence: 99%

Long-term day-and-night rotating shift work poses a barrier to the normalization of alanine transaminase

Lin

Hsieh

Chen

2013

Chronobiology International

View full text Add to dashboard Cite

To evaluate the impact of day-and-night rotating shift work (RSW) on liver health, we performed a retrospective analysis of the association between long-term RSW exposure and the normalization of plasma alanine transaminase (ALT) levels over a five-year period. The data from physical examinations, blood tests, abdominal sonographic examinations, personal histories, and occupational records were collected from a cohort of workers in a semiconductor manufacturing company. The sample population was divided into three subgroups for analysis, according to self-reported shift work status over the five-year interval: persistent daytime workers, workers exposed intermittently to RSW (i-RSW), and workers exposed persistently to RSW (p-RSW). Records were analyzed for 1196 male workers with an initial mean age of 32.5 years (SD 6.0 years), of whom 821 (68.7%) were identified as rotating shift workers, including 374 i-RSW (31.3%) and 447 p-RSW workers (37.4%). At the beginning of the follow-up, 275 were found to have elevated ALT (e-ALT): 25.1% daytime workers, 23.0% i-RSW workers, and 21.3% p-RSW workers (p = 0.098). Of those with e-ALT at the beginning, 101 workers showed normalized serum ALT levels at the end of five-year follow-up: 40 (10.7%) of 375 daytime workers, 32 (8.6%) of 374 i-RSW workers, and 29 (6.5%) of 447 p-RSW workers (p = 0.016). Compared with the workers having persistent e-ALT at the end of follow-up, the workers normalized serum ALT levels had significantly lesser exposures to RSW during follow-up. By performing multivariate logistic regression analyses, and comparing with the persistent daytime co-workers, after controlling for confounding variables (age, occupational factors, educational levels, lifestyle factors, metabolic syndrome, hepatovirus infection, and fatty liver), analysis indicated that the workers exposed to p-RSW were 46% less likely (OR, 0.54; 95% CI, 0.30-0.95; p = 0.03) to attain normal ALT levels within a five-year interval. These observations demonstrate that persistent day-and-night RSW pose a vigorous obstacle to the normalization of e-ALT among workers with preexisting abnormal liver function. We suggest that workers and managers approach with caution the consideration of assigning or accepting long-term day-and-night RSW when an employee health screening shows evidence of abnormal liver function.

show abstract

“…In a logistic regression model, taking age, sex, BMI, and duration of diabetes into consideration, increased levels of ASAT, ALAT, and ALP were correlated with an increased risk of developing insulin resistance. The authors noted that the majority of their patients with the most severe insulin resistance had ultrasound-proven liver steatosis [89].…”

Section: Prevalence Of Nafld In Type 1 Diabetes Patientsmentioning

confidence: 99%

Hepatic Steatosis in Type 1 Diabetes

Regnell

Lernmark

2011

Rev Diabet Stud

View full text Add to dashboard Cite

■ AbstractIslet autoimmunity in type 1 diabetes results in the loss of the pancreatic β-cells. The consequences of insulin deficiency in the portal vein for liver fat are poorly understood. Under normal conditions, the portal vein provides 75% of the liver blood supply. Recent studies suggest that non-alcoholic fatty liver disease (NAFLD) may be more common in type 1 diabetes than previously thought, and may serve as an independent risk marker for some chronic diabetic complications. The pathogenesis of NAFLD remains obscure, but it has been hypothesized that hepatic fat accumulation in type 1 diabetes may be due to lipoprotein abnormalities, hyperglycemia-induced activation of the transcription factors carbohydrate response element-binding protein (ChREBP) and sterol regulatory element-binding protein 1c (SREBP-1c), upregulation of glucose transporter 2 (GLUT2) with subsequent intrahepatic fat synthesis, or a combination of these mechanisms. Novel approaches to non-invasive determinations of liver fat may clarify the consequences for liver metabolism when the pancreas has ceased producing insulin. This article aims to review the factors potentially contributing to hepatic steatosis in type 1 diabetes, and to assess the feasibility of using liver fat as a prognostic and/or diagnostic marker for the disease. It provides a background and a case for possible future studies in the field.

show abstract

Nonalcoholic Fatty Liver Disease Markers Are Associated with Insulin Resistance in Type 1 Diabetes

Cited by 27 publications

References 53 publications

Alkaline phosphatase is independently associated with renal function in normoalbuminuric type 1 diabetic patients

Alkaline phosphatase is independently associated with renal function in normoalbuminuric type 1 diabetic patients

Long-term day-and-night rotating shift work poses a barrier to the normalization of alanine transaminase

Hepatic Steatosis in Type 1 Diabetes

Contact Info

Product

Resources

About