Nonalcoholic Fatty Liver Disease: Diagnostic and Fat-Grading Accuracy of Low-Flip-Angle Multiecho Gradient-Recalled-Echo MR Imaging at 1.5 T

Yokoo, Takeshi; Bydder, Mark; Hamilton, Gavin; Middleton, Michael S.; Gamst, Anthony; Wolfson, Tanya; Hassanein, Tarek; Patton, Heather; Lavine, Joel E.; Schwimmer, Jeffrey B.; Sirlin, Claude B.

doi:10.1148/radiol.2511080666

Cited by 294 publications

(438 citation statements)

References 53 publications

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“…The influence of J-coupling on established T 2 values for lipids has been acknowledged (11,18,21,35), and to minimize its affect on calculated T 2 , STEAM (stimulated echo acquisition mode) (36), or PRESS sequences with a range of short TEs were employed (7,11,18,21). In this work we applied a technique, previously employed to rewind the scalar coupling evolution of lipid methyl protons at 3 T (26), to the 2.1 ppm lipid allylic protons, to the 2.3 ppm lipid protons in a position to the carbonyl group, and to the 2.8 ppm lipid diallylic protons.…”

Section: Discussionmentioning

confidence: 99%

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Effect of J‐coupling on lipid composition determination with localized proton magnetic resonance spectroscopy at 9.4 T

Yahya

Tessier²,

Fallone

2011

Magnetic Resonance Imaging

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Purpose: To demonstrate, at 9.4 T, that J-coupling interactions exhibited by lipid protons affects lipid composition determination with a point resolved spectroscopy (PRESS) sequence. Materials and Methods:Experiments were conducted on four oils (almond, corn, sesame, and sunflower), on visceral adipose tissue of a euthanized mouse, and on pure linoleic acid at 9.4 T. The 2.1, 2.3, and 2.8 ppm resonances were measured at multiple echo times (TEs) by a standard PRESS sequence and by a PRESS sequence consisting of narrow-bandwidth refocusing pulses designed to rewind the J-coupling evolution of the target peak protons in the voxel of interest. T 2 corrections were performed on both groups of data for the three peaks and lipid compositions for the oils and for the mouse tissue were determined. Lipid compositions were also calculated from a short-TE standard PRESS spectrum.Results: A chemical analysis of the samples was not performed; however, the oil compositions calculated from resonance peaks acquired with the PRESS sequence designed to minimize J-coupling effects, following T 2 relaxation correction, closely agreed with values in the literature, which was not the case for all of the compositions determined from the regular PRESS spectra. Conclusion:The presented work brings to attention the significance of J-coupling effects when calculating lipid compositions from localized proton spectra.

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Section: Discussionmentioning

confidence: 99%

“…LIPID MEASUREMENTS by proton magnetic resonance spectroscopy (MRS) have been useful in understanding a number of disorders, including diabetes (1-3), obesity (3)(4)(5), liver disease (6,7), and cancer (3,(8)(9)(10). It has been suggested that there may be a link between the composition of fatty tissue and the risk of suffering from such diseases (11,12).…”

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confidence: 99%

Effect of J‐coupling on lipid composition determination with localized proton magnetic resonance spectroscopy at 9.4 T

Yahya

Tessier²,

Fallone

2011

Magnetic Resonance Imaging

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“…86 Table 3 presents results of the imaging techniques used in diagnosis of NAFLD-NASH. 86,[90][91][92][93][94][95][96][97][98][99][100][101][102][103][104][105][106][107][108][109] The underlying physical principle of imaging techniques are the same between adults and children. Consequently research in both age groups could be used to approve the use of these methods in pediatric field.…”

Section: Image Studiesmentioning

confidence: 99%

“…101 Liver stiffness measurement by transient elastography is a reliable method for predicting significant liver fibrosis. [102][103][104][105][106][107][108] Discordance of transient elastography with liver pathology may be related to unsatisfactory liver biopsy specimen. 101 Magnetic resonance offers imaging and spectroscopic methods for quantification of fat with relatively high accuracy without any invasive procedures or radiation exposure.…”

Section: Magnetic Resonance Imagingmentioning

confidence: 99%

Nonalcoholic fatty liver disease: a challenge for pediatricians

Widhalm

Ghods

2010

Int J Obes

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Background: Nonalcoholic fatty liver disease (NAFLD) is the most common cause of pediatric liver disease. Its prevalence is related to the growing epidemic in childhood obesity during the past decades. At present, NAFLD and nonalcoholic steatohepatitis (NASH) are increasingly recognized worldwide. In spite of alarming trend in the epidemiology in pediatric field and growing risk of end stage liver disease, there is no significant advance in its diagnosis and treatment. Aim: To provide a detailed review for diagnosis and management of NAFLD and NASH. Methods: By using Pubmed to find review articles and relevant research. Results: The prevalence ranges from at least 3% in children overall to about 50% in obese children. The noninvasive biomarkers can be used to identify NAFLD/NASH patients. Diagnostic criteria based on biochemical and immunological indicators in the high-risk group of children could prevent about half of cases from receiving an invasive test. The pharmacological and surgical interventions have shown a growing role in pediatric NAFLD. Novel treatment modalities, such as probiotics, have hardly been studied. Conclusion: Early diagnosis by using noninvasive screening methods in high-risk groups is the most effective strategy against the NAFLD. The biology of early growth and development, including hepatic metabolism, may hold the key to pediatric NAFLD. Prevention of overweight children and childhood obesity is undoubtedly the best strategy for treating NAFLD.

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“…On in-phase images, the signal intensity difference between lobes is likely to be smaller. Advanced MR imaging techniques that are designed to simultaneously assess fat and iron accumulation are now being developed (16,17). These techniques are likely to facilitate the diagnosis of lobar fat accumulation that is superimposed over iron overload; however, these techniques are not yet commercially available.…”

Section: Fat Accumulationmentioning

confidence: 99%

CT and MRI of diffuse lobar involvement pattern in liver pathology

Karçaaltıncaba¹,

Sirlin²

2010

Diagn Interv Radiol

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Focal, segmental, and diffuse liver pathologies have been described in the literature. This article describes a pattern in which liver pathology is confined to a lobe. This lobar pattern has not been described previously to our knowledge. Herein, we illustrate computed tomography (CT) and magnetic resonance imaging (MRI) findings of diffuse lobar involvement patterns in various liver conditions. Diffuse lobar involvement can be observed in benign (steatosis, hepatic iron overload, cholestasis, perfusion alterations, infarction, alveolar hydatid cysts, trauma, and hemangiomas) and primary malignant (hepatocellular carcinoma) pathologies. Diffuse lobar involvement in metastatic disease appears to be rare. Due in part to their potentially unusual appearances, the diagnosis of lobar pathologies using imaging can be challenging, and entities with lobar patterns can cause diagnostic confusion. Liver MRI can be used as a problem-solving tool for diffuse lobar pathologies detected on ultrasonography and CT. Inand out-of-phase MRI can help in the assessment of lobar fat accumulation.

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Nonalcoholic Fatty Liver Disease: Diagnostic and Fat-Grading Accuracy of Low-Flip-Angle Multiecho Gradient-Recalled-Echo MR Imaging at 1.5 T

Abstract: Relaxation- and interference-corrected fat quantification at low-flip-angle multiecho GRE MR imaging provides high diagnostic and fat-grading accuracy in NAFLD.

Cited by 294 publications

References 53 publications

Effect of J‐coupling on lipid composition determination with localized proton magnetic resonance spectroscopy at 9.4 T

Effect of J‐coupling on lipid composition determination with localized proton magnetic resonance spectroscopy at 9.4 T

Nonalcoholic fatty liver disease: a challenge for pediatricians

CT and MRI of diffuse lobar involvement pattern in liver pathology

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