Nonalcoholic fatty liver disease and the risk of insulin-requiring gestational diabetes

You, Sang Youn; Han, Kyungdo; Lee, Seung-Hawn; Kim, Mee Kyoung

doi:10.1186/s13098-021-00710-y

Cited by 9 publications

(4 citation statements)

References 25 publications

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“…Moreover, a stronger correlation was found in the cohort of women without metabolic syndrome before pregnancy. This confirms the hypothesis that NAFLD is an independent risk factor for CKD, regardless of the presence or absence of metabolic syndrome [35].…”

Section: Aimsupporting

confidence: 87%

Gestational diabetus mellitus and its complications, role of desynchronosis in pathogenesis (a review)

Khara,

Korda,

Podilska

2023

Patologìâ

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Diabetes mellitus is the most common metabolic disorder during pregnancy. The International Diabetes Federation estimates that one in six pregnant women (16.8 %) has diabetes. The prevalence of this disease in the human population is striking and, according to various sources, accounts for 14–25 % of all pregnant women. Most cases of hyperglycemia during pregnancy (75–90 %) is due to gestational diabetes mellitus (GDM). Risk factors, etiology and pathophysiology of GDM are being actively studied, but there are still some controversial issues. For example, the development of GDM in the aspect of circadian rhythm disorders. This problem is especially relevant in connection with pregnancy. After all, there is a two-way relationship here – circadian rhythm disorders affect the course of pregnancy, and pregnancy can be the cause of these disorders. In addition, this problem is relevant for women with a history of endocrine disorders, including diabetes mellitus, as there is a clear link between circadian rhythms and the production of hormones, including insulin. The aim of this review was to show the relationship between the development of GDM, its complications, and circadian rhythm disorders in women. Pregnancy complicated by GDM can have a negative effect on the myocardium and liver. Moreover, this disease has a significant impact on the myocardium of the offspring. GDM also can cause other complications for the mother’s health and fetus or newborn. Scientists have identified a fairly significant number of risk factors for GDM. However, circadian rhythm disorders accompanying pregnancy are often underestimated as a risk factor. In general, there are many controversies regarding the relationship between long / short sleep duration and quality and the risk of developing diabetes, as well as how melatonin and its precursor serotonin affect metabolism in critical organs. Thus, the role of circadian rhythm disorders in the development of diabetes and its consequences is not yet fully understood. It is likely that solving the problem of circadian rhythm disorders will be the key to overcoming a significant proportion of cases of GDM. Therefore, there is an urgent need for further, larger-scale studies to investigate the causal links between circadian rhythm disorders, diabetes mellitus, and pregnancy.

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Section: Aimsupporting

confidence: 87%

Gestational diabetus mellitus and its complications, role of desynchronosis in pathogenesis (a review)

Khara,

Korda,

Podilska

2023

Patologìâ

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“…It has been observed that pregnancy, despite being a physiological moment in a woman's life, can evoke early symptoms of future pathologies such as NAFLD. Several studies, based on the correlation of events occurring in pregnancy and the manifestation of NAFLD over time, have shown an association between some conditions, such as gestational diabetes mellitus (GDM) or eclampsia, and NAFLD in older women [68]. This correlation is confirmed in the study conducted by Hagstrom et al, which considers a A variety of foods contain choline, with meat, fish, nuts, dairy products and eggs providing the richest sources.…”

Section: Pregnancy and Breast Feeding Are Alarm Bells For Nafld In Pr...mentioning

confidence: 81%

Premenopausal Syndrome and NAFLD: A New Approach Based on Gender Medicine

et al. 2022

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Non-alcoholic fatty liver disease (NAFLD) is a multifactorial condition that affects 25% of the world’s population. There is a clear difference in both geographical distribution and sex in childbearing age. These differences are reduced when women become older and senescence begins. The factors that affect the likelihood of developing NAFLD in a premenopausal woman are an imbalance of sex hormones (especially in estradiol and androgen), microbiome dysregulation, insulin resistance, early menarche, the length of time that the woman breastfeeds for and polycystic ovarian syndrome (PCOS). The aim of this review is to identify various physical ailments that may not appear to be serious to young women but that then affect the onset of NAFLD in perimenopause and can degenerate into NASH. These conditions should also be considered in future clinical management, as well as in research opportunities, in order to customize the monitoring and treatment of NAFLD, considering gender medicine for those women who had early metabolic symptoms that were not considered to be significant at the time.

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“…In a large cohort study, NAFLD was detected as a significant risk factor for developing insulin-requiring GDM. Females with NAFLD had a higher likelihood of requiring insulin for GDM (OR=4.19; 95% CI 3.37-5.23), with risk increasing across fatty liver index categories [10].…”

Section: Discussionmentioning

confidence: 99%

From Gestational Diabetes to Fatty Liver: Tracking the Journey to Prediabetes and Diabetes in Women – A Prospective Observational Study

Behera,

Kumari

2024

IJMBS

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Background: Gestational diabetes mellitus (GDM) and non-alcoholic fatty liver disease (NAFLD) are recognized risk variables for the development of prediabetes and diabetes. Understanding the combined effect of these conditions on the progression to glucose intolerance is crucial for developing effective prevention strategies. The study aimed to examine the incidence of prediabetes and diabetes in females with a history of GDM and NAFLD, in contrast to those with only one or neither condition, and to identify key risk factors related with these outcomes. Methods: 200 women were enrolled in a prospective observational study and allocated into four groups: Group A (GDM only), Group B (NAFLD only), Group C (both GDM and NAFLD), and Group D (control group with neither condition). Participants were followed for two years, with incidence rates of prediabetes and diabetes recorded. Baseline characteristics were assessed, and Cox proportional hazards models were used to identify significant risk factors. Results: The highest incidence of prediabetes and diabetes was observed in Group C, with 60% developing prediabetes and 50% developing diabetes. Group A had 40% prediabetes and 20% diabetes incidence, Group B had 36% and 24%, respectively, and Group D had 20% and 10%. Higher BMI, family history of diabetes, history of GDM, and presence of NAFLD were significant risk factors, while healthy dietary habits were protective. Conclusion: Females with a history of both GDM and NAFLD are at a considerably higher risk of developing prediabetes and diabetes. These findings underline the importance of targeted prevention and early intervention strategies in this high-risk population. Recommendations: Healthcare providers should prioritize monitoring and managing women with both GDM and NAFLD to prevent the onset of prediabetes and diabetes. Regular screening and promoting healthy lifestyle modifications are essential to mitigate these risks. Keywords: Gestational Diabetes Mellitus, Non-Alcoholic Fatty Liver Disease, Prediabetes, Diabetes, Risk Factors, Preventive Strategies

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Nonalcoholic fatty liver disease and the risk of insulin-requiring gestational diabetes

Cited by 9 publications

References 25 publications

Gestational diabetus mellitus and its complications, role of desynchronosis in pathogenesis (a review)

Gestational diabetus mellitus and its complications, role of desynchronosis in pathogenesis (a review)

Premenopausal Syndrome and NAFLD: A New Approach Based on Gender Medicine

From Gestational Diabetes to Fatty Liver: Tracking the Journey to Prediabetes and Diabetes in Women – A Prospective Observational Study

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