Nonalcoholic Fatty Liver Disease and Mean Platelet Volume

Madan, Shivank; John, Febin; Pitchumoni, C. S.

doi:10.1097/mcg.0000000000000340

Cited by 38 publications

(40 citation statements)

References 36 publications

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“…MPV and PDW used to evaluate platelet function and activity is a cost‐effective and routinely available test. Increased MPV was associated with a higher risk of death after MI, a higher coronary stent restenosis rate and higher morbidity and cardiovascular mortality risk after a stroke (Arevalo‐Lorido et al., ; Balli et al., ; Madan, John, & Pitchumoni, ). The findings from the meta‐analysis provide strong epidemiological evidence for the important role of platelet in ED pathogenesis.…”

Section: Discussionmentioning

confidence: 99%

Mean platelet volume, platelet distribution width and platelet count in erectile dysfunction: A systematic review and meta-analysis

Ren

Yang

et al. 2017

Andrologia

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The aim of this study was to investigate the relationship between mean platelet volume (MPV), platelet distribution width (PDW), platelet count (PC) and erectile dysfunction (ED). We searched for observational studies from PubMed, EMBASE, Web of Science and CNKI up to 31 March 2016. Two reviewers independently selected the studies and extracted the data. MPV, PDW, and PC and mean differences in these platelet indices between healthy subjects and ED patients were explored using the Comprehensive Meta-Analysis software package. Seven studies including 795 patients and 524 healthy subjects met the inclusion criteria. The MPV was significantly larger in patients with ED than controls with the standardised mean difference of 0.596 fL (95% CI: 0.378, 0.815, p < 0.001). In ED patients, the pooled mean difference in MPV between vasculogenic ED patients and nonvasculogenic ED patients was 0.706 fL in case-control studies (95% CI: 0.410, 1.002, p < 0.001). There was no significant difference in PDW and PC between healthy subjects and ED patients. The available data suggest that larger MPV was associated with ED. Patients with vasculogenic ED tend to have higher MPV than nonvasculogenic ED patients. Further studies are needed to assess whether increased MPV in ED patients is associated with increased cardiovascular disease.

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Section: Discussionmentioning

confidence: 99%

Mean platelet volume, platelet distribution width and platelet count in erectile dysfunction: A systematic review and meta-analysis

Ren

Yang

et al. 2017

Andrologia

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“…Mean platelet volume, a readily available parameter from CBC, provides significant clues about the megakaryocytic activity and platelet activation [8,17]. Mean platelet volume has been found to be increased in a number of diseases like heart disease [6,[18][19][20], type 2 diabetes mellitus [21], nonalcoholic fatty liver disease [22], pancreatitis [23] and malignancies [24]. More importantly, higher MPV values were demonstrated to be associated with higher mortality in coronary artery disease [6,18,20], and increased risk of stroke in atrial fibrillation patients [19].…”

Section: Discussionmentioning

confidence: 99%

The association of mean platelet volume and platecrit and bone marrow fibrosis in patients with essential thrombocythemia: A cohort study

Eren¹,

Doğu²,

Koç³

et al. 2019

Journal of Surgery and Medicine

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Aim: Essential thrombocythemia (ET) patients exhibit higher mean platelet volume (MPV) values compared to the healthy individuals. However, the association of degree of bone marrow fibrosis with either MPV or platecrit (PCT) has not been evaluated previously. The aim of this study was to investigate MPV and PCT values as predictive markers for evaluating bone marrow fibrosis (BMF) in ET patients. Methods: We conducted a retrospective cohort study to analyze the data of ET patients, who were followed in outpatient clinic of our hematology department, between January 2015 and December 2016. Patients older than 18 years, who had bone marrow biopsy, CBC, biochemistry tests and an abdominal sonography performed at the time of diagnosis, JAK2 test ordered and were BCR-ABL negative were included in the study. The patients were divided into two groups according to the presence of BMF as "the BMF group" and "the non-BMF group". The cutoff value for MPV and PCT was determined according to the median value. Fisher's exact test and χ 2 were used for comparative statistical analysis. Results: There were 22 males and 26 females with a median age of 56 years (range, 28-81). The BMF group included 35 (73%) patients while the non-BMF group included 13 (27%) patients. The median MPV was 8.8 fL (6.6-11.5) and median PCT was 0.69% (0.42-2.26), which was considered as the cutoff values for these parameters. There was no significant difference between the groups in patients with MPV ≤8.8 fL and MPV >8.8 fL (p=0.104) and also in patients with PCT ≤0.69% and PCT >0.69% (p=0.616). Conclusion: There is no association between the BMF and MPV and PCT in ET patients. However this is the first study investigating the role of both MPV and PCT in BMF in ET patients.

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“…In a Korean cross-sectional study, Shin et al have observed that the increased values of mean platelet volume (MPV) was significantly associated with the prevalence of non-alcoholic hepatic steatosis in obese population, even after adjustment for confounding variables [ 22 ]. In a recent meta-analysis, Madan et al also reported that MPV is significantly higher in patients with NAFLD, indicating the presence of increased platelet activity in such patients [ 23 ]. Therefore, the previous and present findings implicated that the characteristics of the peripheral platelet in NAFLD individuals should be further investigated in future.…”

Section: Discussionmentioning

confidence: 99%

Risk of reduced platelet counts in patients with nonalcoholic fatty liver disease (NAFLD): a prospective cohort study

Liu¹,

Zhou²,

Cao³

et al. 2018

Lipids Health Dis

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BackgroundThe production of peripheral platelet is mainly regulated by thrombopoietin, which is a glycoprotein hormone predominantly synthesized in the liver. Previously, many studies have reported that there was an inverse correlation between the degree of chronic viral hepatitis and the peripheral platelet count. However, the effect of nonalcoholic fatty liver disease (NAFLD) on the peripheral platelet counts remains unclear.MethodsWith 1303 participants from “The prevention of MS and multi-metabolic disorders in Jiangsu province of China (PMMJS)” cohort study, we investigated the associations between NAFLD and the risk of platelet counts reduction in Chinese adults. The paired-samples T test was used to explore the platelet counts changes between baseline and follow-up. Multivariate logistic regression was used to examine the association between presence of NAFLD and the risk of platelet reduction by calculating the odds ratios (ORs) and 95% confidence interval (CI).ResultsAfter five years of follow-up, platelet counts were markedly reduced from 220.6 ± 42.22 (109/L) at baseline to 208.41 ± 40.70 (109/L) at follow-up in NAFLD group (P < 0.0001). However, platelet counts were slightly lowered from 213.2 ± 43.26(109/L) at baseline to 211.8 ± 41.65 (109/L) at follow-up in non-NAFLD people (P = 0.2349). Meanwhile, there was a significant association between NAFLD and the risks of platelet count reduction, even after adjustment for confounding variables (OR: 1.68, 95% CI: 1.06–2.67). Additionally, among the participants with BMI ≤ 23 kg/m2 and SUA ≤ 344.3 μmol/L, the NAFLD participants have an increased risk of platelet count reduction compared to the persons in non-NAFLD group.ConclusionsOur present results suggested that NAFLD individuals have an increased risk of platelet counts reduction.Electronic supplementary materialThe online version of this article (10.1186/s12944-018-0865-7) contains supplementary material, which is available to authorized users.

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Nonalcoholic Fatty Liver Disease and Mean Platelet Volume

Cited by 38 publications

References 36 publications

Mean platelet volume, platelet distribution width and platelet count in erectile dysfunction: A systematic review and meta-analysis

Mean platelet volume, platelet distribution width and platelet count in erectile dysfunction: A systematic review and meta-analysis

The association of mean platelet volume and platecrit and bone marrow fibrosis in patients with essential thrombocythemia: A cohort study

Risk of reduced platelet counts in patients with nonalcoholic fatty liver disease (NAFLD): a prospective cohort study

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