Nonadherence to antihypertensive drugs

Abegaz, Tadesse Melaku; Shehab, Abdulla; Gebreyohannes, Eyob Alemayehu; Bhagavathula, Akshaya Srikanth; Elnour, Asim Ahmed

doi:10.1097/md.0000000000005641

Cited by 363 publications

(202 citation statements)

References 52 publications

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“…42-46 Drug poor or non-adherence is perhaps the most common and important risk factor of heart failure among patients with hypertension. In the systematic analysis by Abegaz et al 47 , 43 to 65.5% of patients who fail to adhere to prescribed medications are hypertensives. In this study, 45.2% of hypertensive patients were non-adherent to medications, 31.2% of those hypertensives with co-morbidities were non-adherent with 83.7% of non-adherence noticed in those with uncontrolled blood pressure.…”

Section: Discussionmentioning

confidence: 99%

Risk factors of heart failure among patients with hypertension attending a tertiary hospital in Ibadan, Nigeria: The RISK-HHF case-control study

Oguntade

Ajayi

2020

Preprint

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Background: Hypertension is the leading cause of heart failure in sub-Saharan Africa. Preventive public health approach to reduce the scourge of HF must seek to understand the risk factors of heart failure in at risk populations. The aim of this study was to characterize the modifiable risk factors of HF among patients with hypertension attending a cardiology clinic. Methods: One hundred and one (101) case-control age- and sex-matched pairs were recruited. The study population were adults with a clinical diagnosis of hypertensive heart failure (cases) and hypertension. They were interviewed and evaluated for modifiable cardiovascular risk factors. Associations between variables were tested with McNemar’s chi square test and paired sample t test as appropriate. Conditional logistic regression modelling was used to determine the risk factors of HF in the study population while ‘punafcc’ package in stata15 was used to calculate the population attributable fraction (PAF) of risk factors. Results: Low education attainment ( aOR: 2.38, 95% CI: 0.91-6.20; PAF: 21.1%, 95% CI: 5.1-34.5 ) showed borderline association with HF while alcohol consumption (aOR: 10.40, 95% CI: 2.30-47.04; PAF: 33.5%, 95% CI: 21.6-43.6) and suboptimal medication adherence (aOR: 7.00, 95% CI: 2.31-21.26; PAF: 69.7%, 95% CI: 59.4-77.4) were strong risk factors for HF even after adjustment for other modifiable risk factors. These three dominant risk factors accounted for 89% of the PAF of HF. Dietary factors were not significantly associated with HF risk in adjusted analyses. Conclusions: The risk factors for heart failure in hypertensive patients are largely modiﬁable. Public health interventions and preventive cardiovascular care to improve medication adherence and reduce alcohol consumption among patients with hypertension are recommended.

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Section: Discussionmentioning

confidence: 99%

Risk factors of heart failure among patients with hypertension attending a tertiary hospital in Ibadan, Nigeria: The RISK-HHF case-control study

Oguntade

Ajayi

2020

Preprint

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“…Another possible reason is that older people might have more than one disease due to aging process, which might have led them using many drugs which make them tired, hence, stop taking drugs. Also, cognitive and functional impairment in elderly patients increases their risk of poor drug compliance, so they need a family to remind, support and assist them in taking drugs [21].…”

Section: Discussionmentioning

confidence: 99%

Using the Health Believe Model to Explain the Patient’s Compliance to Anti-hypertensive Treatment in Three District Hospitals - Dar Es Salaam, Tanzania: A Cross Section Study

Joho

Leshabari

2019

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Background Hypertension is one of the most important cardiovascular risk factors; but compliance to anti-hypertensive medications remains to be a public health challenge worldwide. Health belief model have been used to explain adoption of preventive measures to health problems. This study used the health belief model as a framework to explain the compliance to anti-hypertensive drugs among elderly hypertensive patients. The study aimed at finding the influence of health belief model in treatment compliance among elderly hypertensive patients in three district hospitals in Dar es Salaam, Tanzania. Methods We conducted an analytical cross- sectional study in three District hospitals in Dar es Salaam Region. We included patients who were on antihypertensive medications. Simple random sampling was used to enrol study participants. Data were collected using structured questionnaires. Data were analysed using SPSS. Frequency distribution and Multivariate analysis was done using Linear Multiple Regression to identify variables which are strongest predictor of treatment compliance among variables of Health Believe Model. Results: A total of 135 participants were enrolled, 56% were compliant to treatment. Multiple linear regression was used to operationalize the Health Belief Model with treatment compliance being dependant variable. The predictor variables were perceived benefit, perceived barriers and cues to action. Multivariate analysis indicated significant model fit for the data (F = 11.19 and P value < 0.001). The amount of variance in treatment compliance that is explained by the predictors is 30.3% (R² = 0.303) with perceived barrier being the strongest predictor of treatment compliance (β = -0.477; p < 0.001). A negative beta coefficient indicates a negative association between perceived barriers and treatment compliance. Other predictor variables were not statistically associated with treatment compliance. Conclusion: The study showed that almost half of study participants had hypertensive treatment compliance, with the use of health believe model the important strongest variable was perceived barrier to treatment. An innovative strategy on improving patients’ perception of barrier to treatment is recommended to increase treatment compliance. Key words: Hypertension, Treatment compliance, lifestyle

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“…No entanto, a escala ainda mais utilizada é o MAQ, mesmo apresentando uma consistência interna de baixa qualidade 26;44 e um desempenho fraco. No caso de usuários de medicamentos anti-hipertensivos, tem-se outra realidade, a MMAS-8 é considerada a escala mais conhecida e amplamente utilizada para investigar a adesão à farmacoterapia 49 . Identificaram-se outras três escalas de aferição por autorrelato, além da MMAS-8, que também são apropriadas para hipertensão: o BMQ, a escala de Hill-Bone Compliance e a escala de adesão de Culig 49 .…”

Section: Discussionunclassified

Métodos para aferir a adesão à farmacoterapia em doenças crônicas: uma revisão narrativa

2017

JAFF

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Resumo: Estima-se que a não-adesão atinja quase a metade dos usuários crônicos de medicamento. Objetivo: considerando a importância da identificação da não-adesão à farmacoterapia, tem-se o objetivo de mapear a literatura existente no que diz respeito aos métodos de aferi-la. Método: esta revisão narrativa foi conduzida sem limitação temporal, por meio de buscas realizadas nas bases de dados MEDLI-NE/PubMed, Scielo e Google Acadêmico. Para isso, utilizaram-se os descritos em Ciências da Saúde (DeCS) (Medication Adherence e Adesão à Medicação; Patient Compliance e Cooperação do Paciente; Surveys and Questionnaires e Inquéritos e Questionários); os termos MESH (medication adherence, patient compliance, surveys and questionnaires); e outros termos gerais. Resultados: os métodos para aferir adesão são categorizados em medidas diretas e indiretas. Não há um padrão ouro para aferir a adesão, pois sempre há vantagens e desvantagens em cada método. A medida indireta de autorrelato parece ser o método mais indicado para monitorar a adesão e avaliar o comportamento da não-adesão e para ser utilizado na prática clínica. Conclusão: apesar da riqueza de informações encontradas nesta área, não há consenso entre os pesquisadores. Deve-se verificar qual dimensão se quer medir quanto à adesão e então escolher o instrumento adequado ou então associar instrumentos para realizar a medida pretendida.

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Nonadherence to antihypertensive drugs

Abstract: Supplemental Digital Content is available in the text

Cited by 363 publications

References 52 publications

Risk factors of heart failure among patients with hypertension attending a tertiary hospital in Ibadan, Nigeria: The RISK-HHF case-control study

Risk factors of heart failure among patients with hypertension attending a tertiary hospital in Ibadan, Nigeria: The RISK-HHF case-control study

Using the Health Believe Model to Explain the Patient’s Compliance to Anti-hypertensive Treatment in Three District Hospitals - Dar Es Salaam, Tanzania: A Cross Section Study

Métodos para aferir a adesão à farmacoterapia em doenças crônicas: uma revisão narrativa

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