A reverse dispersion fiber (RDF) with depressed core-index profile has been developed successfully using plasma chemical vapor deposition (PCVD) process. The fabricated RDF has a core-effective-area of 45 µm 2 , dispersion of -19.65 ps/nm/km and dispersion slope of -0.132ps/ nm 2 /km while maintaining the low bending induced attenuation and low PMD value. The dispersion-managed pairs, which consisted of RDF and non-zero dispersion shifted fiber with ultra large effective core-area (ULAF), have the ultra low dispersion slope of less than 0.006 ps/ nm 2 /km at the wavelength range of 1530 nm to 1625 nm, and the largest dispersion value is lower than 0.2 ps/nm/ km. Moreover, the attenuation characteristic also shows a remarkable flatness over the broadband wavelength, the attenuation at 1550 nm is only 0.224 dB/km. The dispersion-managed pairs are suitable for large capacity, high bit-rate long-haul wavelength division multiplexing (WDM) transmission system without using dispersion compensation mode.