Non-weight-bearing effect of trunk and peripheral fat mass on bone mineral density in pre- and post-menopausal women

Kuwahata, A.; Kawamura, Yukie; Yonehara, Yukie; Matsuo, Takashi; Iwamoto, Ichiro; Douchi, Tsutomu

doi:10.1016/j.maturitas.2008.07.005

Cited by 23 publications

(24 citation statements)

References 21 publications

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“…To demonstrate that body composition is related to bone mineral density, body fat mass should be analyzed as visceral fat and subcutaneous fat. Peripheral fat mass is not correlated to bone mineral density,40 whereas visceral fat (intra-abdominal fat) mass might have a linkage with BMD 41. Imaging analysis using CT scans is also essential to evaluate the exact distribution of visceral fat and subcutaneous fat and their effects on bone 41.…”

Section: Discussionmentioning

confidence: 97%

Relation between Obesity and Bone Mineral Density and Vertebral Fractures in Korean Postmenopausal Women

et al. 2010

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PurposeThe traditional belief that obesity is protective against osteoporosis has been questioned. Recent epidemiologic studies show that body fat itself may be a risk factor for osteoporosis and bone fractures. Accumulating evidence suggests that metabolic syndrome and the individual components of metabolic syndrome such as hypertension, increased triglycerides, and reduced high-density lipoprotein cholesterol are also risk factors for low bone mineral density. Using a cross sectional study design, we evaluated the associations between obesity or metabolic syndrome and bone mineral density (BMD) or vertebral fracture.Materials and MethodsA total of 907 postmenopausal healthy female subjects, aged 60-79 years, were recruited from woman hospitals in Seoul, South Korea. BMD, vetebral fracture, bone markers, and body composition including body weight, body mass index (BMI), percentage body fat, and waist circumference were measured.ResultsAfter adjusting for age, smoking status, alcohol consumption, total calcium intake, and total energy intake, waist circumference was negatively related to BMD of all sites (lumbar BMD p = 0.037, all sites of femur BMD p < 0.001) whereas body weight was still positively related to BMD of all sites (p < 0.001). Percentage body fat and waist circumference were much higher in the fracture group than the non-fracture group (p = 0.0383, 0.082 respectively). Serum glucose levels were postively correlated to lumbar BMD (p = 0.016), femoral neck BMD (p = 0.0335), and femoral trochanter BMD (p = 0.0082). Serum high density lipoprotein cholesterol (HDLC) was positively related to femoral trochanter BMD (p = 0.0366) and was lower in the control group than the fracture group (p = 0.011).ConclusionIn contrast to the effect favorable body weight on bone mineral density, high percentage body fat and waist circumference are related to low BMD and a vertebral fracture. Some components of metabolic syndrome were related to BMD and a vertebral fracture.

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Section: Discussionmentioning

confidence: 97%

Relation between Obesity and Bone Mineral Density and Vertebral Fractures in Korean Postmenopausal Women

et al. 2010

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“…Several authors have suggested that LM is the best predictor of BMD, whereas FM is negatively related to bone mass when adjusted for body weight. 15,16 Other cross-sectional studies suggested that bone density is related to FM, 17 and even others showed that both LM and FM are related to bone mass. 6,18 However, most of these studies were conducted with postmenopausal women, and only limited data are available in men, among whom some reported that LM determines bone mass, whereas FM was not related to bone mineral measures in men.…”

Section: Discussionmentioning

confidence: 97%

Age and sex effects on the association between body composition and bone mineral density in healthy Chinese men and women

et al. 2012

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“…This implies that bone strength is primarily determined by the dynamic loads from muscle force, but not by the static loads, such as FM [41]. Furthermore, the effect of ovarian estrogen may override the effect of aromatized estrogen derived from FM on BMD in premenopausal women [42]. After menopause, some changes, including a decrease in LM and increase in FM, occur in body composition, and the biochemical functions of FM may become prominent.…”

Section: Discussionmentioning

confidence: 99%

Associations of fat mass and fat distribution with bone mineral density in pre- and postmenopausal Chinese women

Han

et al. 2010

Osteoporos Int

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Non-weight-bearing effect of trunk and peripheral fat mass on bone mineral density in pre- and post-menopausal women

Cited by 23 publications

References 21 publications

Relation between Obesity and Bone Mineral Density and Vertebral Fractures in Korean Postmenopausal Women

Relation between Obesity and Bone Mineral Density and Vertebral Fractures in Korean Postmenopausal Women

Age and sex effects on the association between body composition and bone mineral density in healthy Chinese men and women

Associations of fat mass and fat distribution with bone mineral density in pre- and postmenopausal Chinese women

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