Non-Viral Gene Therapy Vectors for Cancer Treatment

Kanvinde, Shrey; Kulkarni, Tanmay; Deodhar, Suyash; Bhattacharya, Deep; Dasgupta, Aneesha

doi:10.20944/preprints202201.0372.v1

Cited by 3 publications

(2 citation statements)

References 108 publications

(146 reference statements)

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“…Exploring innovative vectors, such as nanoparticles and liposomes, is essential. Non-viral delivery vectors are categorized into lipidbased and polymeric vectors (Kanvinde et al, 2022). Another potential approach for transgene delivery involves gene silencing.…”

Section: Genetics In Neurodegenerative Diseasementioning

confidence: 99%

The role of neuroinflammation in neurodegenerative diseases: current understanding and future therapeutic targets

Adamu,

Li,

Gao

et al. 2024

Front. Aging Neurosci.

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Neuroinflammation refers to a highly complicated reaction of the central nervous system (CNS) to certain stimuli such as trauma, infection, and neurodegenerative diseases. This is a cellular immune response whereby glial cells are activated, inflammatory mediators are liberated and reactive oxygen and nitrogen species are synthesized. Neuroinflammation is a key process that helps protect the brain from pathogens, but inappropriate, or protracted inflammation yields pathological states such as Parkinson’s disease, Alzheimer’s, Multiple Sclerosis, and other neurodegenerative disorders that showcase various pathways of neurodegeneration distributed in various parts of the CNS. This review reveals the major neuroinflammatory signaling pathways associated with neurodegeneration. Additionally, it explores promising therapeutic avenues, such as stem cell therapy, genetic intervention, and nanoparticles, aiming to regulate neuroinflammation and potentially impede or decelerate the advancement of these conditions. A comprehensive understanding of the intricate connection between neuroinflammation and these diseases is pivotal for the development of future treatment strategies that can alleviate the burden imposed by these devastating disorders.

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Section: Genetics In Neurodegenerative Diseasementioning

confidence: 99%

The role of neuroinflammation in neurodegenerative diseases: current understanding and future therapeutic targets

Adamu,

Li,

Gao

et al. 2024

Front. Aging Neurosci.

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“…Based on the literature, PEI/DNA polyplexes have been repeatedly shown to be more stable than PEI/siRNA polyplexes [ 96 ]. Ziebarth and co-workers examined the potential causes of this difference by using molecular dynamic simulations to study complexation between PEI and nucleic acids [ 97 ].…”

Section: Polymer-based Na Vehiclesmentioning

confidence: 99%

Non-Viral Vectors for Delivery of Nucleic Acid Therapies for Cancer

Kanvinde

Kulkarni

Deodhar

et al. 2022

BioTech

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The research and development of non-viral gene therapy has been extensive over the past decade and has received a big push thanks to the recent successful approval of non-viral nucleic acid therapy products. Despite these developments, nucleic acid therapy applications in cancer have been limited. One of the main causes of this has been the imbalance in development of delivery vectors as compared with sophisticated nucleic acid payloads, such as siRNA, mRNA, etc. This paper reviews non-viral vectors that can be used to deliver nucleic acids for cancer treatment. It discusses various types of vectors and highlights their current applications. Additionally, it discusses a perspective on the current regulatory landscape to facilitate the commercial translation of gene therapy.

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