Non-viral gene delivery carrier and its three-dimensional transfection system

He, Cai‐Xia; Tabata, Yasuhiko; Gao, Jian

doi:10.1016/j.ijpharm.2009.11.006

Cited by 91 publications

(88 citation statements)

References 117 publications

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“…Both, lipo-and polyplexes are still under intense investigation as nuclear-targeted DNA delivery systems as alternative to viral transfrection vectors (38)(39)(40)(41)(42). During the 1990s, the assembly of lipid-DNA complexes has been intensively investigated, and several models have been proposed, which are comprehensively summarized in (43).…”

Section: Mitochondria-targeted Dna Deliverymentioning

confidence: 99%

From Serendipity to Mitochondria-Targeted Nanocarriers

Weissig

2011

Pharm Res

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This review illustrates how a random observation at the laboratory bench has helped pave the way towards the development of organelle-targeted pharmaceutical nanocarriers. A fortuitous discovery in the mid 1990s involving the self-assembly of a molecule, known to accumulate inside mitochondria, has lead to the development of subcellular nanocarriers suited for the selective delivery of biologically active molecules to mitochondria inside living mammalian cells. Applications for mitochondria-specific drug and DNA delivery are described, the current state-of-the-art of mitochondrial drug targeting technology is reviewed, and its future perspectives are discussed.

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Section: Mitochondria-targeted Dna Deliverymentioning

confidence: 99%

From Serendipity to Mitochondria-Targeted Nanocarriers

Weissig

2011

Pharm Res

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“…Efforts have been made to increase the delivery efficiency of non-viral vectors, including the creation of sophisticated vehicles able to mimic some of the viral properties regarding both size and biological properties [2]. These vectors are called "artificial viruses" and include polymeric constructs [4][5][6], protein-only shells and virus-like particles [4]. Among the properties of these vectors are the ability to condense and protect DNA from nuclease degradation, low systemic and cellular toxicity, membrane crossing abilities, and steady expression of the therapeutic gene [7].…”

Section: Introductionmentioning

confidence: 99%

Development of a recombinant fusion protein based on the dynein light chain LC8 for non-viral gene delivery

Toledo

Janissen

Favaro

et al. 2012

Journal of Controlled Release

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“…109 The first one used a pDNA encoding for the luciferase enzyme and NIH 3T3 cells ( Figure 20). The second one used a pDNA encoding for bone morphogenetic protein-2 (BMP-2) and human mesenchymal stem cells (hMSCs) (Figure 21).…”

Section: In Vitro Gene Transfection Studiesmentioning

confidence: 99%