Non-vasogenic cystoid maculopathies

Gaudric, Alain; Audo, Isabelle; Vignal, Catherine; Couturier, Aude; Boulanger-Scemama, Élise; Tadayoni, Ramin; Cohen, Salomon Y.

doi:10.1016/j.preteyeres.2022.101092

Cited by 12 publications

(14 citation statements)

References 423 publications

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“…In this case series, we describe NOPPES of the retina, which consists of peripapillary schisis-like IRF, in 1 case in combination with localized SRF, that was not caused by macular neovascularization, a diagnosis from the pachychoroid disease spectrum, such as PPS, or any other diagnostic entity that has been described previously. NOPPES may, therefore, be considered a differential diagnostic entity that has not been described within the broad spectrum of diseases that can cause peripapillary or nasal macular IRF, as well as SRF 1,6 …”

Section: Discussionmentioning

confidence: 99%

“…Diseases that can cause peripapillary IRF range from neovascular diseases (eg, neovascular AMD and polypoidal choroidal vasculopathy) to diseases that are part of the pachychoroid disease spectrum [PPS (Fig. 6C), CSC], tumors (choroidal hemangioma and melanoma), advanced glaucoma, and vascular eye disease (diabetic retinopathy and retinal vein occlusions) 1,6 . Furthermore, ocular developmental disorders, such as an (acquired) optic disc pit (Fig.…”

Section: Discussionmentioning

confidence: 99%

“…NOPPES may, therefore, be considered a differential diagnostic entity that has not been described within the broad spectrum of diseases that can cause peripapillary or nasal macular IRF, as well as SRF. 1,6 NOPPES provides a challenge for clinicians, as alternative diagnoses should first be excluded.…”

Section: Discussionmentioning

confidence: 99%

“…Besides PPS, peripapillary SRF or IRF can be caused by a wide spectrum of diseases, such as neovascularization (eg, in neovascular AMD or polypoidal choroidal vasculopathy), diseases from the pachychoroid disease spectrum (eg, CSC or PPS), diabetic macular edema, or glaucoma-related retinoschisis. 1,[6][7][8][9] A comprehensive differential diagnosis of peripapillary schisis-like IRF is shown in Table 1. It is important to ascertain the correct diagnosis, using multimodal imaging (MMI), as a correct diagnosis ensures the choice of a fitting treatment, when available.…”

Section: Introductionmentioning

confidence: 99%

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NOn-Pachychoroid PEripapillary Schisis (NOPPES) of the Retina: A New Phenotype and its Differential Diagnosis

Sirks,

van Dijk,

Pauleikhoff

et al. 2023

Asia-Pacific Journal of Ophthalmology

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Purpose: The presence of peripapillary intraretinal fluid (IRF) has a broad differential diagnosis, including several types of neovascular and pachychoroid-related diseases. However, the clinician may encounter cases without signs of neovascular or pachychoroid disease, or any other previously described diagnosis. For these patients, we propose the term NOn-Pachychoroid PEripapillary Schisis (NOPPES) of the retina, and we discuss the differential diagnosis. Design: A retrospective chart study set in a tertiary referral center for retinal diseases in Amsterdam, the Netherlands. Methods: Using multimodal imaging, cases suspected of peripapillary pachychoroid syndrome were reviewed. Cases without signs of neovascular or pachychoroid disease were included in this study. These cases were discussed in a group of senior retinal specialists to establish a diagnosis, and if there was no evidence for any previously described diagnostic entity, these cases were categorized as NOPPES. Results: Four cases of NOPPES were identified, 3 female patients and 1 male patient, aged between 58 and 75 years. Two patients were myopic, and 1 patient had a mild hyperopia. Three out of 4 cases showed unilateral peripapillary IRF, and 1 case had bilateral IRF. No improvement was seen after intravitreal bevacizumab or aflibercept, nepafenac eye drops, oral acetazolamide, vitrectomy with internal limiting membrane peeling, or surgery for carotid stenosis. One case showed a reduction in IRF after starting prednisolone eye drops. Conclusions: We describe NOPPES, a new form of peripapillary schisis-like IRF. NOPPES seems relatively therapy-resistant. More research is needed to delineate the clinical spectrum of NOPPES and its pathogenesis and treatment.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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NOn-Pachychoroid PEripapillary Schisis (NOPPES) of the Retina: A New Phenotype and its Differential Diagnosis

Sirks,

van Dijk,

Pauleikhoff

et al. 2023

Asia-Pacific Journal of Ophthalmology

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“…CME occurrence may be related to poor blood-retinal barrier function, localized intraretinal inflammation, autoimmune processes, tangential vitreous traction, and/or reduced RPE function in the retinal dystrophies and the authors suggested that the occurrence of macular cystoid spaces that was already altered by the atrophic process seemed to be a more degenerative process than due to a blood-retina barrier breakdown in BCD patients. 84 Saatci et al 85 described 27-year-old male BCD patient with bilateral CME. There was bilateral petaloid-type late hyperfluorescence documented on fluorescein angiography.…”

Section: Posterior Segment Complicationsmentioning

confidence: 99%

Diagnostic and Management Strategies of Bietti Crystalline Dystrophy: Current Perspectives

Saatçi¹,

Atas²,

Çetin³

et al. 2023

OPTH

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Bietti crystalline dystrophy (BCD) is a rare, genetically determined chorioretinal dystrophy presenting with intraretinal crystalline deposits and varying degrees of progressive chorioretinal atrophy commencing at the posterior pole. In some cases, there can be concomitant corneal crystals noted first in the superior or inferior limbus. CYP4V2 gene, a member of the cytochrome P450 family is responsible for the disease and more than 100 mutations have been defined thus far. However, a genotype–phenotype correlation has not been established yet. Visual impairment commonly occurs between the second and third decades of life. By the fifth or sixth decade of life, vision loss can become so severe that the patient may potentially become legally blind. Multitudes of multimodal imaging modalities can be utilized to demonstrate the clinical features, course, and complications of the disease. This present review aims to reiterate the clinical features of BCD, update the clinical perspectives with the help of multimodal imaging techniques, and overview its genetic background with future therapeutic approaches.

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