Non-vascular vitreoretinopathy: The cells and the cellular basis of contraction

Abstract

SUMMARYBackground: We consider epiretinal membranes in

A comparative study of epiretinal membranes associated with Eales' disease: a clinicopathologic evaluation

“…They include retinal pigment epithelium (RPE) and retinal glial cells in proliferative vitreoretinopathy (PVR), vascular endothelium, fibroblasts, and macrophages in retinal vasoproliferative disorders such as diabetic retinopathy and vascular occlusions and blood cellular components in inflammatory disorders. [11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30] Aetiopathogenesis of Eales' disease is not well understood because of lack of appropriate specimen for microbiology and histopathology studies. The availability of tissue specimen in active stages of the disease is quite unlikely because it is a disease of young healthy persons and involves the retinal periphery in its early stages.…”

Effect of Robo1 on Retinal Pigment Epithelial Cells and Experimental Proliferative Vitreoretinopathy

“…[1][2][3] Although modern vitreoretinal microsurgery has improved treatment in PVR and PDR, in many cases there are technical failures or the visual results are poor. 4 -6 It is therefore important to obtain a better understanding of the pathogenesis of this disorder, to devise strategies for its prevention and for improved treatments.…”

Transforming Growth Factor-β2 and Connective Tissue Growth Factor in Proliferative Vitreoretinal Diseases

“…ontraction and remodeling of matrix are important elements of the tissue repair process; however, excessive contraction induces pathological scarring in a variety of tissues, such as skin (1) and the eye (2,3). Despite the dramatic development of vitreoretinal surgery, proliferative vitreoretinal diseases such as proliferative vitreoretinopathy (PVR) and proliferative diabetic retinopathy (PDR) still remain common causes of severe visual loss or blindness (4,5).…”