Non Urothelial Bladder Cancers: A Case Series

Abstract

Non urothelial bladder cancers frequently present a diagnostic and therapeutic challenge. The article presents a case series of 21 patients of non urothelial urinary bladder cancers presented in our institute over a period of three years and review of literature on this rare condition. Details of patients were reviewed from hospital records of surgical, medical, radiotherapy and pathology departments. Simple percentage and frequencies have been used to interpret the data. Total 21 patients were included in the study. 12 (57.2 %) were males and 9 (42.8 %) were females (M: F :: 4:3). Mean age of the patients was 51.3 years ranging from 22 to 65 years. Eleven (52.3 %) out of twenty one patients had hematuria as their presenting complaint. Out of 21, there were nine (42.8 %) adenocarcinoma, nine (42.8 %) were SCC and one (4.76 %) each of carcinosarcoma, neuroendocrine tumor and sarcoma. Fourteen (66.6 %) patients out of 21 were referred for upfront surgery. Out of remaining seven (33.33 %) patients from the non surgical group three were referred for definitive concurrent chemoradiation, two for definitive radiotherapy. One patient of adenocarcinoma (non urachal) was referred for palliative chemotherapy. Remaining one patient of neuroendocrine tumor who was referred for neoadjuvant chemotherapy died before any definitive treatment could be considered. This study highlights the role of surgery and status of adjuvant therapies in the management of non urothelial bladder cancers.

A clinico-pathological study of non-urothelial bladder cancers in a cohort of patients from a tertiary care urology unit in Sri Lanka

“…The prevalence is reported to be considerably higher in the developing world, accounting for up to 11% [6]. In a series by Ravi et al from India, out of 21 non-urothelial tumours, 9 (42.8 %) were adenocarcinoma with a mean age of 49.33 years [2]. Male to female ratio was 2: 1.…”

“…Male to female ratio was 2: 1. Two (22.2%) were urachal tumours and 4 (44.44%) were moderately differentiated while 5 (55.55%) were poorly differentiated [2]. In a study by Grignon, out of 72 patients with adenocarcinoma 24 patients had urachal and 48 patients had non urachal …”

“…Non-urothelial bladder cancers are known to occur in around 5% of all bladder cancers [1]. Due to the rarity of non-urothelial bladder cancers, understanding of the clinico-pathological characteristics and effective management strategies are poor, particularly in the South Asian region [2]. Therefore, this study aimed to describe the clinico-pathological characteristics of non-urothelial bladder cancers.…”

Oncological Outcomes of Non-Urothelial Bladder Cancers in a Specialized Cancer Hospital of a Developing Country

“…Radical cystectomy is the treatment of choice for localized SCC because benefits from radiation are uncertain, and standard chemotherapy has little effect due to relative chemoresistance of disease [ 10 ]. Adenocarcinoma accounts for about 2% of BCs, and to establish the diagnosis of primary adenocarcinoma of the bladder, other possible primary tumors sites such as adenocarcinoma of the prostate or rectum should be ruled out [ 11 , 12 ]. Apart from endemic areas, adenocarcinoma is the most prevalent NUBC.…”