“…Indeed, the clinical implications in terms of hospital overcrowding are critically dependent on the local organization of healthcare; that is, whether or not an immediate and direct transfer from the ED to other appropriate care settings is available. A wide implementation of these care pathways seems to be essential to reduce the burden of unnecessary hospitalization [48]. Moreover, our study might have overestimated the rate of inappropriate hospitalizations because of daytime recruitment of patients, since it is reasonable to assume a higher proportion of patients appropriately accessing the ED, and thus later being appropriately hospitalized, at night and during weekends.…”