Non-uremic calciphylaxis and Chagas disease

Vicco, Miguel Hernán; Ferini, Franco; Rodeles, Luz; Baretta, Melisa; Marcipar, Iván Sergio

doi:10.1016/j.rce.2014.02.013

Cited by 2 publications

(5 citation statements)

References 9 publications

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“…Hammadah et al reported a case of successful resolution of NUC in a patient with acral gangrene with treatment using sodium thiosulphate . Vicco et al reported a case of NUC associated with congestive heart failure secondary to Chagas disease. Vicco found that as the cardiac function improved, so did the NUC wounds.…”

Section: Discussionmentioning

confidence: 99%

“…Vicco found that as the cardiac function improved, so did the NUC wounds. Thus, suggesting a possible connection between poor wound healing and cardiac function . However, Vicco also mentioned that because of the lack of evidence indicating association between cardiac function and wound healing, the coincidence of improving NUC wounds with improved cardiac function could simply be due to the resolution of Chagas disease itself.…”

Section: Discussionmentioning

confidence: 99%

“…Thus, suggesting a possible connection between poor wound healing and cardiac function. 2 However, Vicco also mentioned that because of the lack of evidence indicating association between cardiac function and wound healing, the coincidence of improving NUC wounds with improved cardiac function could simply be due to the resolution of Chagas disease itself. The parasite Trypanosoma cruzi is known to cause several immunological disturbances and could result in the development of NUC.…”

Section: Discussionmentioning

confidence: 99%

“…The hallmarks of calciphylaxis that differentiates it from other vascular calcifications is the systematic calcification of the arterial tunica media layer with potential fibrosis and necrosis of surrounding adipose tissue. People who are diagnosed with calciphylaxis are reported to have 1‐year mortality rates from 52% to as high as 81% . The leading cause of death from calciphylaxis is sepsis.…”

Section: Introductionmentioning

confidence: 99%

“…People who are diagnosed with calciphylaxis are reported to have 1-year mortality rates from 52% to as high as 81%. [1][2][3][4][5] The leading cause of death from calciphylaxis is sepsis. Although calciphylaxis is most common among Caucasian females in their fifth decade of life, it has also been reported among the younger population including children.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Non‐uraemic calciphylaxis successfully treated with pamidronate infusion

Truong

Riedhammer

Zinszer

2018

International Wound Journal

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Calciphylaxis is a rare and potentially fatal disease that affects the subcutaneous layer of the skin. It is a calcific vasculopathy induced by a systemic process that causes occlusion of small blood vessels. The mortality rate for individuals diagnosed with calciphylaxis is estimated between 52% and 81% with sepsis being the leading cause of death. Uraemic calciphylaxis and its known effective treatments are well documented in the literature. Unfortunately, there is no known effective treatment for non‐uraemic calciphylaxis. Most of the current treatments for non‐uraemic calciphylaxis are derived from uraemic calciphylaxis treatment protocols. We report a case of a 75‐year‐old female with calciphylaxis on the right lower extremity who was successfully treated with four pamidronate infusions in addition to local wound care. This case represents a non‐uraemic calciphylaxis wound successfully treated with pamidronate infusions and standard wound care, and suggests that IV pamidronate can be an effective treatment option.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%