Dissolved oxygen, ***Rn, pC02, alkalinity, respiration rate, and discharge have been measured at eight mainstem and seven tributary stations during February-March 1984 in a 1,700-km stretch of the Amazon River between Vargem Grande and Obidos in Brazil. Air-water gas exchange rates were estimated two ways: measurements of the flux of 222Rn into floating domes yielded an average boundary layer thickness of 78 pm, and oxygen mass balance calculations resulted in an average of 38 pm. Given a boundary layer thickness on the order of 50 pm, CO, loss to the atmosphere in the entire reach would have been 37.4 kmol s-l, which is about equal to the total tributary dissolved inorganic carbon (DIC) input (43 kmol s-l) and is about half of the total fluvial DIC input to the section (97.7 kmol s-l). Thus, CO, evasion is a major component of Amazon River DIC balance. Because gas exchange within the section was rapid relative to water travel time through the section, a quasi-steady state was maintained between respiratory input and evasion of CO,. Dissolved ***Rn activities in the mainstem varied from 3.5 to 8.3 dpm liter-' and were always highly supersaturated with respect to the atmosphere. Dissolved radon was also not supported by decay ~f~*~Ra (0.59-0.70 dpm liter-') in the mainstem. A ***Rn mass balance indicated that direct groundwater input into this stretch of the Amazon mainstem probably accounted for no more than 1% of water discharge.