Non-uniform swelling properties of the corneal stroma

Lee, David; Wilson, Graeme

doi:10.3109/02713688109019986

Cited by 62 publications

(35 citation statements)

References 7 publications

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“…The hydration of each section was calculated for both the physiological and the swollen corneas. The results (Figure 3) confirm results from other species [27][28][29] and show that hydration increases with tissue depth in both the physiological and the swollen human corneas. This may be related to the gradual increase in the KS/DS ratio with depth, since KS is known to show greater water absorption than DS.…”

Section: Direct Summation Of Fields Methodssupporting

confidence: 85%

“…In many animals, the anterior stroma is less ordered, 15 less hydrated, 27-29 has a higher keratocyte density, 22,23 has a lower keratan sulphate (KS) to chondroitin/ dermatan sulphate (DS) ratio, 28 and is less easily swollen [29][30][31] than the posterior stroma. We have examined four frozen human corneas (two at physiological hydration and two swollen in culture medium).…”

Section: Direct Summation Of Fields Methodsmentioning

confidence: 99%

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Transparency, swelling and scarring in the corneal stroma

Meek

Leonard

Connon

et al. 2003

Eye

195

132

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Section: Direct Summation Of Fields Methodssupporting

confidence: 85%

Section: Direct Summation Of Fields Methodsmentioning

confidence: 99%

Transparency, swelling and scarring in the corneal stroma

Meek

Leonard

Connon

et al. 2003

Eye

195

132

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“…It has long been thought that lamella inclination and insertion into Bowman's layer provides mechanical stabilization of the refractive surface [26][27][28][29]. High-resolution macroscopic imaging, which combines many SHG image stacks to produce entire limbus-to-limbus stromal threedimensional cross-sections, has allowed some lamellae to be traced over millimetres, even with branching and led to the discovery of 'bow string' fibres that enter and exit Bowman's layer [35,36].…”

mentioning

confidence: 99%

A structural model for thein vivohuman cornea including collagen-swelling interaction

Cheng

Petsche

Pinsky

2015

J. R. Soc. Interface.

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A structural model of the in vivo cornea, which accounts for tissue swelling behaviour, for the three-dimensional organization of stromal fibres and for collagen-swelling interaction, is proposed. Modelled as a binary electrolyte gel in thermodynamic equilibrium, the stromal electrostatic free energy is based on the mean-field approximation. To account for active endothelial ionic transport in the in vivo cornea, which modulates osmotic pressure and hydration, stromal mobile ions are shown to satisfy a modified Boltzmann distribution. The elasticity of the stromal collagen network is modelled based on three-dimensional collagen orientation probability distributions for every point in the stroma obtained by synthesizing X-ray diffraction data for azimuthal angle distributions and second harmonicgenerated image processing for inclination angle distributions. The model is implemented in a finite-element framework and employed to predict free and confined swelling of stroma in an ionic bath. For the in vivo cornea, the model is used to predict corneal swelling due to increasing intraocular pressure (IOP) and is adapted to model swelling in Fuchs' corneal dystrophy. The biomechanical response of the in vivo cornea to a typical LASIK surgery for myopia is analysed, including tissue fluid pressure and swelling responses. The model provides a new interpretation of the corneal active hydration control (pump-leak) mechanism based on osmotic pressure modulation. The results also illustrate the structural necessity of fibre inclination in stabilizing the corneal refractive surface with respect to changes in tissue hydration and IOP.

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“…34,35 Stromal water content varies with depth. The anterior stroma has a lower water content than the posterior stroma, 36,37 such that deeper ablations may encounter variable tissue hydration. Individual variations in stromal water content may also exist resulting in possible inconsistencies in stromal ablation.…”

Section: Discussionmentioning

confidence: 99%

Variables affecting refractive outcome following LASIK for myopia

Feltham

Wong

Wolfe³

et al. 2007

Eye

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Aim To investigate factors affecting refractive outcome following LASIK for myopia. Method Six hundred and seventy-four consecutive uncomplicated myopic LASIK surgeries, performed by a single surgeon, either using the Technolas 217 planoscan (n ¼ 372) or the NIDEK EC 5000 (n ¼ 302), were evaluated. Stratified random sampling was used to match the groups for refractive error, patient age, and gender. The final analysis included 302 patients from each treatment group. Conditions were identical for both surgeries, and pre-operative refractive errors were between À1.00 and À14.00 DS and oÀ1.50 DC. Refractive success was defined as À0.50 to þ 0.50 DS of the targeted refraction measured 3 months after surgery. A stepwise logistical regression analysis was used to determine variables associated with refractive failure. Results A successful refractive outcome was achieved in 78% (235/302) of surgeries using the Technolas laser and in 88% (266/302) using the NIDEK laser. Predictor variables for not achieving refractive success were pre-operative refractive error of above À5.00 DS, age more than 40 years, and surgery performed with the Technolas laser. Conclusion Both the Technolas 217 and the NIDEK EC-5000 excimer lasers achieve a successful refractive outcome in the majority of cases. However, patient and surgical factors can influence refractive outcome.

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Non-uniform swelling properties of the corneal stroma

Cited by 62 publications

References 7 publications

Transparency, swelling and scarring in the corneal stroma

Transparency, swelling and scarring in the corneal stroma

A structural model for thein vivohuman cornea including collagen-swelling interaction

Variables affecting refractive outcome following LASIK for myopia

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