1992
DOI: 10.1016/0304-3940(92)90472-j
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Non-uniform distribution of GABA activated chloride channels in cultured cortical neurons

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Cited by 13 publications
(5 citation statements)
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“…Postsynaptic membrane specializations resembling PSDs unapposed to presynaptic elements are observed in developing (Hinds and Hinds, 1976;Blue and Parnavelas, 1983) and adult CNS tissue (Desmond and Levy, 1998). In culture, uninnervated cortical neurons have GABA A response "hot spots" (Frosch and Dichter, 1992), and early in development hippocampal neurons cluster NMDA receptors and associated proteins in the absence of cellcell contact . Cholinergic cultures of purified motoneurons form spontaneous extrasynaptic clusters of glycine and GABA A receptors (Levi et al, 1999).…”
Section: Spontaneous Formation Of Both Presynaptic and Postsynaptic Ementioning
confidence: 97%
“…Postsynaptic membrane specializations resembling PSDs unapposed to presynaptic elements are observed in developing (Hinds and Hinds, 1976;Blue and Parnavelas, 1983) and adult CNS tissue (Desmond and Levy, 1998). In culture, uninnervated cortical neurons have GABA A response "hot spots" (Frosch and Dichter, 1992), and early in development hippocampal neurons cluster NMDA receptors and associated proteins in the absence of cellcell contact . Cholinergic cultures of purified motoneurons form spontaneous extrasynaptic clusters of glycine and GABA A receptors (Levi et al, 1999).…”
Section: Spontaneous Formation Of Both Presynaptic and Postsynaptic Ementioning
confidence: 97%
“…Some variations of this technique have since been developed for specific experimental situations (Levitan and Kramer, 1990;Jonas et al, 1997), and together these methods have allowed recording in an enormous variety of situations. Data from this type of experiment, along with a host of other work, have shown that ion channels frequently associate with specific subcellular structures and are not uniformly distributed on the cell surface; this is important for their function (Joe and Angelides, 1992;Angelides, 1986;Banke et al, 1997;Alkondon, 1996;Tousson et al, 1989;Frosch and Dichter, 1992;Kinnamon et al, 1988;Karpen et al, 1992;Cohen et al, 1991;Gu et al, 2002;Korchev et al, 2000a) However, the available methods remain limited when it comes to studying this subcellular distribution of channels. For example, it is still difficult to record from fine structures such as microvilli and the fine dendritic branches of neurons or to patch opaque samples or obscured structures such as transverse tubules from muscle.…”
Section: Introductionmentioning
confidence: 98%
“…Studies on neuronal cultures, which offer the advantage that an overall picture of receptor distribution can be obtained, have also provided strong evidence for postsynaptic receptor clustering. Clusters of glycine receptors, GABAA receptors, and postsynaptic a-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA)-selective glutamate receptors develop within 1-2 weeks in appropriate neuronal cultures (12)(13)(14), and physiological studies confirm the existence of GABAA and glutamate receptor hot spots (15)(16)(17)(18)(19).…”
mentioning
confidence: 94%