Non-typhoidal Salmonella Osteomyelitis of the Femoral Neck in an Immunocompetent Child

Kung, Yin Hsiang; Liang, Jiun Lung; Kuo, Kuang-Che

doi:10.4172/2167-7921.1000241

Cited by 1 publication

(3 citation statements)

References 7 publications

(15 reference statements)

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“…Salmonella osteomyelitis is more common in children with SCD, primary immunodeficiencies (defects of the IL-2/IFN-γ axis) and acquired immunodeficiencies (HIV, malignancy, immunosuppressive therapy) 4–7 9–11. In otherwise healthy children, it is very rarely reported 4–9. A recent review shows 46 cases of osteomyelitis due to NTS in children without a known immunodeficiency or SCD between 1960 and 2016 7.…”

Section: Discussionmentioning

confidence: 99%

“…MRI is the most sensitive imaging exam in detecting earlier signs of osteomyelitis,1 2 9 such as marrow oedema, which is present in early stages 1. Evidence suggests that earlier MRI leads to a reduced hospital stay 2…”

Section: Discussionmentioning

confidence: 99%

“…Most cases of Salmonella osteomyelitis occur in individuals with immunodeficiencies or haemoglobinopathies, mainly sickle cell disease (SCD), but are very rare in healthy children 4–9. Non-typhoidal Salmonella (NTS) strains are the most commonly implicated, namely Salmonella enteritidis , Salmonella typhimurium and Salmonella paratyphi B 7 8 .…”

Section: Introductionmentioning

confidence: 99%

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MetatarsalSalmonella enteritidisosteomyelitis in a healthy child

Limão¹,

Carvalho

Viana

et al. 2019

BMJ Case Rep

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Non-typhoidal Salmonella osteomyelitis in healthy children is a very rare condition. A previously healthy 7-year-old boy presented with foot pain following a small injury. Local inflammatory signs of the foot were observed, with a normal radiograph. Two weeks before, he had had gastroenteritis. Assuming cellulitis, flucloxacillin was began. Early during admission, surgical subcutaneous abscess drainage was performed and Salmonella enteritidis was identified. According to bacterial susceptibility, antibiotherapy was changed to ceftriaxone. A foot radiograph and an MRI scan, performed on the 9th and the 12th days, revealed findings suggestive of osteomyelitis of the metaphysis of the fifth metatarsal. Clinical worsening persisted and surgical extensive debridement was needed. A 6-week antibiotic treatment was completed, with a good outcome. Osteomyelitis with a poor evolution in children with risk factors (prior gastrointestinal illness, warm weather and previous exposure to antibiotics) can raise the possibility of a non-typhoidal Salmonella infection.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%