Non-Trophoblastic Tumours of the Placenta

Fox, H.; Sebire, Neil J

doi:10.1016/b978-1-4160-2592-4.50019-9

Cited by 31 publications

(41 citation statements)

References 199 publications

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“…Hyalinisation, necrotic and calcified foci were the other findings. In the current case, our findings were consistent with previous studies in humans and animals (Kirkbride et al, 1973;Batukan et al, 2001;Kurman, 2002;Fox, 2003). We reported chorangioma associated with trophoblastic proliferation in a sheep.…”

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confidence: 83%

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Histopathologic findings in multicentric placental chorangioma with trophoblastic proliferation in a sheep

Azizi¹,

Kheirandish²,

Oloumi³

et al. 2017

BJVM

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The present study described chorangioma in a sheep with clinical signs of dystocia. During surgery, foetus was not found and both of the uterine horns were distended with a lot of liquid. Multiple welldemarcated nodules of firm consistency, yellow-tan colour and 2.5-4 cm diameter were projected from the cotyledons into the lumens. Histopathologically, the nodules showed expanded chorionic villi composed of proliferated blood vessels in a variable amount of loose perivascular stroma. Syncytial trophoblast cells with hyperchromatic nucleus were dispersed in the tumour's parenchyma. Based on pathologic characteristics and according to the abundant vascular proliferation and nodular form, a neoplastic lesion named chorangioma was diagnosed. To the author's knowledge, it is the first report of chorangioma in sheep.

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confidence: 83%

“…Small size chorangiomas are incidental findings and not clinically significant or detectable during gross inspection (Asadourian & Taylor, 1968;Leonidas et al, 1975;Fox, 2003). Multicentric masses or those larger than 5 cm are usually associated with different complications in the mother or foetus (Asadourian & Taylor, 1968;Leonidas et al, 1975).…”

mentioning

confidence: 99%

Histopathologic findings in multicentric placental chorangioma with trophoblastic proliferation in a sheep

Azizi¹,

Kheirandish²,

Oloumi³

et al. 2017

BJVM

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“…The incidence of large chorangiomas varies between 1:3500 and 1:9000 pregnancies. 2 Although it is a benign lesion, a large chorangioma can result in maternal or fetal complications, such as fetal anemia, hydrops, and fetal death. 3,4 Therefore, every effort should be made to diagnose these lesions and their complications as soon as possible.…”

Section: Introductionmentioning

confidence: 99%

Chorangioma Placentae: A Rare Entity

SinghSunita

GargShilpa

VermaRenuka

et al. 2015

Journal of Gynecologic Surgery

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Background: A chorangioma, a nontrophoblastic tumor, is a primary benign neoplasm of the placenta. It is found on the fetal surface of the placenta or in the placental parenchyma. Chorangiomas can have various histopathologic presentations, ranging from vascular to cellular, and can undergo degenerative changes. They can be diagnosed prenatally with ultrasound, color Doppler imaging, and magnetic resonance imaging. Case: A large placental chorangioma with secondary changes was found in a 32-year-old primigravida female who was referred to the Postgraduate Institute of Medical Sciences, in Rohtak, Haryana, India, at 36 weeks of gestation, with polyhydramnios and intrauterine growth restriction. Results: The patient herself delivered a placenta and deceased fetus without surgical intervention. The patient responded well after treatment. Conclusions: Chorangioma must be differentiated from other villous capillary lesions, namely, chorangiomatosis and chorangiosis. Most chorangiomas are small and possess no clinical significance. On the contrary, clinically significant chorangiomas, greater than 5 cm or multiple, may be associated with pregnancy complications. ( J GYNECOL SURG 31:26)

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“…Rates of intrauterine demise can approach 40% [4] . Fortunately, larger chorioangiomas occur less frequently with a reported incidence of 1: 3,500 to 1: 9,000 [1] .…”

Section: Introductionmentioning

confidence: 99%

“…Placental chorioangiomas are abnormal proliferations of chorionic tissue, identified in approximately 1 in 100 placentas [1,2] . They are often small and not associated with risk to the fetus.…”

Section: Introductionmentioning

confidence: 99%

Fetoscopic Laser Photocoagulation of Feeding Vessels to a Large Placental Chorioangioma following Fetal Deterioration after Amnioreduction

Jones¹,

Tierney²,

Grubbs³

et al. 2011

Fetal Diagn Ther

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Large placental chorioangiomas (>4 cm) can precipitate severe polyhydramnios, fetal anemia, growth restriction, high-output cardiac failure, hydrops, and fetal demise. We report a case of a large chorioangioma that was treated in a stepwise fashion with amnioreduction to ameliorate maternal discomfort, followed by fetoscopic laser ablation of the feeding vessels after rapid evolution of heart failure. Although amnioreduction was helpful in improving maternal symptoms, we suspect that the drop in intrauterine pressure from the amniotic fluid decompression may have resulted in increased tumor perfusion, thereby promoting fetal deterioration due to a ‘steal’ phenomenon. Close scrutiny of the fetal status via ultrasound is required, particularly if amnioreduction is necessary, and definitive treatment should be considered once early signs of heart failure develop. Fetoscopic laser ablation of the feeding vessels is a feasible definitive treatment of a large chorioangioma in cases in which perfusion of the tumor is via a superficial nonterminus umbilical artery. Future reports should describe the anatomy of the blood supply to the chorioangioma, in the hopes that further guidelines for surgical candidacy may be established.

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Non-Trophoblastic Tumours of the Placenta

Cited by 31 publications

References 199 publications

Histopathologic findings in multicentric placental chorangioma with trophoblastic proliferation in a sheep

Histopathologic findings in multicentric placental chorangioma with trophoblastic proliferation in a sheep

Chorangioma Placentae: A Rare Entity

Fetoscopic Laser Photocoagulation of Feeding Vessels to a Large Placental Chorioangioma following Fetal Deterioration after Amnioreduction

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