Non-traumatic spinal cord injury in Norway 2012–2016: analysis from a national registry and comparison with traumatic spinal cord injury

Halvorsen, Annette; Pettersen, Ann Louise; Nilsen, Sara Marie; Halle, K Krizak; Schaanning, E Elmenhorst; Rekand, Tiina

doi:10.1038/s41393-018-0223-7

Cited by 22 publications

(17 citation statements)

References 15 publications

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“…NORSCIPI is the first national study of PI in the SCI population in Norway. Our studypopulation was representative and comparable with previous studies in Norway [20][21]. An important finding in our study was the association between psychological impairments and risk of PI, which is in accordance with previous studies [2,22].…”

Section: Discussionsupporting

confidence: 92%

Spinal cord injury and development of pressure injury during acute rehabilitation in Norway: a national retrospective cross-sectional study

et al. 2020

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Study design A national, retrospective, cross-sectional study.Objectives To analyze the prevalence of pressure injury (PI), and characteristics associated with PI development in the hospitalized population of persons with a newly acquired spinal cord injury (SCI) between 2004 and 2014.Setting All three specialized Spinal Cord Units in Norway.Methods Demographic data related to prevalence and potential risk factors was retrieved from the electronic medical record (EMR). Statistical analyses were performed, using IBM SPSS Statistics, version 23. ResultsWe identified 1012 individuals with a new SCI. Mean age at injury was 48 years (SD 19). The period prevalence of PI was 16 % (95 % CI=0.14-0.19), and identified PI associations were complete SCI (OR=0.1), being injured abroad (OR=2.4), bowel (OR=13) and bladder (OR=9.2) dysfunction, comorbidity like diabetes mellitus 1 (OR=7.9), diagnosed depression (OR=3.8), ventilator support (OR=3.0), drug abuse (OR=3.0), and concurrent traumatic brain injury (OR=1.7). Individuals in the age group 15-29 years had higher odds of PI compared to middleaged individuals (45-59 years).Conclusion PI is a serious complication after SCI. The association between depression or comorbidity and PI occurrence should be investigated more thoroughly. We recommend implementation of a simple follow-up program regarding observation and prevention of PI.Increased awareness of factors that could contribute to PI, will help to focus on better prevention and early recognition of PI. This will contribute to more optimal rehabilitation.

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Section: Discussionsupporting

confidence: 92%

Spinal cord injury and development of pressure injury during acute rehabilitation in Norway: a national retrospective cross-sectional study

et al. 2020

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“…Although slightly lower, our findings are comparable to those from the Western Europe WHO Region for both TSCI (16 cases per million) [ 11 ] and NTSCI [ 3 ]. Similarly, our observed male-to-female ratio reflected previously identified proportions for both TSCI [ 22 , 24 ] and NTSCI [ 25 , 26 ]. In European studies, age at TSCI onset varied between 42 years in Russia [ 27 ] and 59 years in Finland [ 28 ].…”

Section: Discussionsupporting

confidence: 89%

Incidence and mortality of spinal cord injury from 2008 to 2020: a retrospective population-based cohort study in the Piedmont Region, Italy

et al. 2022

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Study design Retrospective population-based cohort study. Objectives To determine the incidence and mortality of spinal cord injuries (SCI) in the Piedmont Region of Northwestern Italy. Setting Publicly-funded SCI rehabilitation centres in the Piedmont Region. Methods Administrative databases were used to identify individuals at their first admission to a SCI rehabilitation centre from January 1st, 2008 to December 31st, 2020. Cases were stratified by age and aetiology (traumatic SCI, TSCI; non-traumatic SCI, NTSCI). Age- and aetiology-specific incidence rate and person-year mortality rates were calculated for each year. Case lethality was reported as deaths among prevalent cases for each year. Results A total of 892 cases were identified (56.4% TSCI). The average annual crude incidence rate was 17.9 per million population, decreasing from 26.0 in 2008 to 10.8 in 2020. Young adults and the elderly represented the majority of TSCI and NTSCI cases, respectively. Of the 235 individuals who died during the study period, 58.3% had NTSCI. The mortality rate per 1000 person-years decreased from 16.3 in 2009 to 8.5 in 2020, while case lethality more than tripled (from 17.2 in 2009 to 57.1 in 2020). Conclusions We identified a decreasing trend in SCI incidence and mortality rates, with an increased case lethality over the study period, especially in NTSCI. Given these changes in the epidemiology of SCI, community services offered after rehabilitation should be strengthened to enhance their effectiveness and contribute to increased survival in this population.

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“…While the epidemiological data are limited, the annual incidence of non-traumatic SCI is estimated to be 6–76 individuals per million. Individuals with non-traumatic SCI are generally older and less severely injured because the causes include degenerative disc disease, spinal canal stenosis, cancer, and vascular events [ 12 ]. A review article reported that many spinal registries only include traumatic SCI or poorly capture non-traumatic SCI, meaning that data regarding rehabilitation are lacking, and only a limited number of studies have investigated their management [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

Regenerative Rehabilitation and Stem Cell Therapy Targeting Chronic Spinal Cord Injury: A Review of Preclinical Studies

Tashiro

Nakamura

2022

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Stem cell medicine has led to functional recovery in the acute-to-subacute phase of spinal cord injury (SCI), but not yet in the chronic phase, during which various molecular mechanisms drastically remodel the tissue and render it treatment-resistant. Researchers are attempting to identify effective combinatorial treatments that can overcome the refractory state of the chronically injured spinal cord. Regenerative rehabilitation, combinatorial treatment with regenerative medicine that aims to elicit synergistic effects, is being developed. Rehabilitation upon SCI in preclinical studies has recently attracted more attention because it is safe, induces neuronal plasticity involving transplanted stem cells and sensorimotor circuits, and is routinely implemented in human clinics. However, regenerative rehabilitation has not been extensively reviewed, and only a few reviews have focused on the use of physical medicine modalities for rehabilitative purposes, which might be more important in the chronic phase. Here, we summarize regenerative rehabilitation studies according to the effector, site, and mechanism. Specifically, we describe effects on transplanted cells, microstructures at and distant from the lesion, and molecular changes. To establish a treatment regimen that induces robust functional recovery upon chronic SCI, further investigations are required of combinatorial treatments incorporating stem cell therapy, regenerative rehabilitation, and medication.

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Non-traumatic spinal cord injury in Norway 2012–2016: analysis from a national registry and comparison with traumatic spinal cord injury

Cited by 22 publications

References 15 publications

Spinal cord injury and development of pressure injury during acute rehabilitation in Norway: a national retrospective cross-sectional study

Spinal cord injury and development of pressure injury during acute rehabilitation in Norway: a national retrospective cross-sectional study

Incidence and mortality of spinal cord injury from 2008 to 2020: a retrospective population-based cohort study in the Piedmont Region, Italy

Regenerative Rehabilitation and Stem Cell Therapy Targeting Chronic Spinal Cord Injury: A Review of Preclinical Studies

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