Non-Transgenic Mouse Models of Kidney Disease

Rabe, Michael; Schaefer, Franz

doi:10.1159/000445171

Cited by 1,377 publications

(58 citation statements)

References 48 publications

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“…The use of ASL in the management of acute kidney injury has been mostly evaluated in animal models [56]. ASL correlated with renal volume loss and histological changes [57], while the combined measurement of tissue perfusion and oxygenation [58] seems to improve the possibility of early detection of disease onset [59].…”

Section: Asl Mri In the Assessment Of Kidney Pathologiesmentioning

confidence: 99%

Renal Arterial Spin Labeling Magnetic Resonance Imaging

Becker

Rossi²

2016

Nephron

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Arterial spin labeling (ASL) MRI allows the quantification of tissue perfusion without administration of exogenous contrast agents. Patients with reduced renal function or other contraindications to Gadolinium-based contrast media may benefit from the non-invasive monitoring of tissue microcirculation. So far, only few studies have investigated the sensitivity, the specificity and the reliability of the ASL techniques for the assessment of renal perfusion. Moreover, only little is known about the interplay between ASL markers of perfusion and functional renal filtration parameters. In this editorial, we discuss the main technical issues related to the quantification of renal perfusion by ASL and, in particular, the latest results in patients with kidney disorders.

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Section: Asl Mri In the Assessment Of Kidney Pathologiesmentioning

confidence: 99%

Renal Arterial Spin Labeling Magnetic Resonance Imaging

Becker

Rossi²

2016

Nephron

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“…Animal models are vital to understand the mechanisms underlying the progression of renal disease and to implement new therapeutic approaches. Several animal models of kidney failure were proposed to study the pathophysiology and complications associated with CKD [1,2,3,4,5]. The most common animal model of CKD is the so-called 5/6 subtotal nephrectomy model (also referred to as the “remnant kidney” model) in which there is a surgical reduction of the renal mass and nephrons number.…”

Section: Introductionmentioning

confidence: 99%

Adenine Rich Diet Is Not a Surrogate of 5/6 Nephrectomy in Rabbits

Florens

Lemoine

Pelletier

et al. 2017

Nephron

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Background: Animal models are important tools needed to understand the mechanisms underlying the progression of renal disease and to implement new therapeutic approaches. A non-surgical model of chronic kidney disease (CKD) developed by chemical nephrectomy using an adenine-enriched diet has been shown to be a robust model to induce kidney failure in mice and rats. The purpose of this study was to implement an adenine diet to induce CKD in rabbits. Methods: Male New Zealand rabbits were fed for 4 weeks with a diet containing 0.75% (w/w) adenine, and renal function was assessed by measuring plasma urea and creatinine concentrations. The glomerular filtration rate (GFR) was measured using the plasmatic clearance of Iohexol. Kidney histology was performed with haematoxylin erythrosine saffron and Sirius red staining. Results: In contrast to what was observed in rodents, adenine diet failed to induce kidney failure in rabbits as is evident in the plasma concentrations of creatinine and urea and the direct measurement of GFR or histopathological studies. Conclusion: Adenine diet is not a surrogate of subtotal nephrectomy to induce kidney failure in rabbits. Several interspecies differences in metabolism and renal physiology could account for this observation.

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“…The reasons for this are differences in trial times and the high variability in diet phosphate and calcium concentrations [24]. The sensitivity to CV calcification also depends on the genetic background, age, and gender of the animals [27]. Female mice show higher susceptibility to CV calcification than males [28], which is the opposite to what observed in humans, wherein men tend to have higher average coronary artery calcium scores than women [29].…”

Section: Animal Models Of Ckdmentioning

confidence: 98%

“…The most commonly used mouse strain is C57Bl/6, which is resistant to the development of hypertension, glomerulosclerosis, and proteinuria. In addition, it shows decreased activity in the renin-angiotensin-aldosterone system, which is important for fibrosis development after five-sixths nephrectomy [27,30]. In summary, compromises have to be made in choosing the right CKD animal model.…”

Section: Animal Models Of Ckdmentioning

confidence: 99%

Cardiovascular Calcification in Chronic Kidney Disease—Therapeutic Opportunities

Himmelsbach

Ciliox

Goettsch

2020

Toxins

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Patients with chronic kidney disease (CKD) are highly susceptible to cardiovascular (CV) complications, thus suffering from clinical manifestations such as heart failure and stroke. CV calcification greatly contributes to the increased CV risk in CKD patients. However, no clinically viable therapies towards treatment and prevention of CV calcification or early biomarkers have been approved to date, which is largely attributed to the asymptomatic progression of calcification and the dearth of high-resolution imaging techniques to detect early calcification prior to the ‘point of no return’. Clearly, new intervention and management strategies are essential to reduce CV risk factors in CKD patients. In experimental rodent models, novel promising therapeutic interventions demonstrate decreased CKD-induced calcification and prevent CV complications. Potential diagnostic markers such as the serum T50 assay, which demonstrates an association of serum calcification propensity with all-cause mortality and CV death in CKD patients, have been developed. This review provides an overview of the latest observations and evaluates the potential of these new interventions in relation to CV calcification in CKD patients. To this end, potential therapeutics have been analyzed, and their properties compared via experimental rodent models, human clinical trials, and meta-analyses.

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Non-Transgenic Mouse Models of Kidney Disease

Cited by 1,377 publications

References 48 publications

Renal Arterial Spin Labeling Magnetic Resonance Imaging

Renal Arterial Spin Labeling Magnetic Resonance Imaging

Adenine Rich Diet Is Not a Surrogate of 5/6 Nephrectomy in Rabbits

Cardiovascular Calcification in Chronic Kidney Disease—Therapeutic Opportunities

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