Non-traditional Alu evolution and primate genomic diversity

Roy-Engel, Astrid M.; Carroll, Marion L.; El-Sawy, M.; Salem, Abdel Halim; Garber, Randall K.; Nguyen, Son; Deininger, Prescott L.; Batzer, Mark A.

doi:10.1006/jmbi.2001.5380

Cited by 91 publications

(67 citation statements)

References 26 publications

(19 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The gene-converted region could be as small as 8 bp (251-259) or as long as 30 bp (237-267) in this case. Thus, the overall gene conversion rate (2/12) we observed here seems to be much higher than in previous studies (Maeda et al 1988;Kass et al 1995;Roy-Engel et al 2002;Salem et al 2003a). However, this is not surprising, since the difference may be due to the small sample size in the current study or reflect the longer evolutionary time period that each element may have been subjected to gene conversion.…”

Section: Aluyb Elements In the Common Chimpanzee Genomecontrasting

confidence: 54%

Under the genomic radar: The Stealth model of Alu amplification

et al. 2005

View full text Add to dashboard Cite

Alu elements are the most successful SINEs (Short INterspersed Elements) in primate genomes and have reached more than 1,000,000 copies in the human genome. The amplification of most Alu elements is thought to occur through a limited number of hyperactive "master" genes that produce a high number of copies during long evolutionary periods of time. However, the existence of long-lived, low-activity Alu lineages in the human genome suggests a more complex propagation mechanism. Using both computational and wet-bench approaches, we reconstructed the evolutionary history of the AluYb lineage, one of the most active Alu lineages in the human genome. We show that the major AluYb lineage expansion in humans is a species-specific event, as nonhuman primates possess only a handful of AluYb elements. However, the oldest existing AluYb element resided in an orthologous position in all hominoid primate genomes examined, demonstrating that the AluYb lineage originated 18-25 million years ago. Thus, the history of the AluYb lineage is characterized by ∼20 million years of retrotranspositional quiescence preceding a major expansion in the human genome within the past few million years. We suggest that the evolutionary success of the Alu family may be driven at least in part by "stealth-driver" elements that maintain low retrotranspositional activity over extended periods of time and occasionally produce short-lived hyperactive copies responsible for the formation and remarkable expansion of Alu elements within the genome.

show abstract

Section: Aluyb Elements In the Common Chimpanzee Genomecontrasting

confidence: 54%

Under the genomic radar: The Stealth model of Alu amplification

et al. 2005

View full text Add to dashboard Cite

show abstract

“…'mosaic evolution' (Labuda and Zietkiewicz, 1994;Zietkiewicz and Labuda, 1996) or 'gene conversion' (Maeda et al, 1988;Roy-Engel et al, 2002a). Such shuffling also occurs with SINE modules.…”

Section: Da Kramerov and Ns Vassetzkymentioning

confidence: 99%

Origin and evolution of SINEs in eukaryotic genomes

2011

View full text Add to dashboard Cite

“…Localization of DSBs may be important for the formation of chromosomal translocations. It has been estimated that approximately 6-13% of genomic DNA consists of repetitive Alu sequences (Mighell et al, 1997;Roy-Engel et al, 2002). DNA sequences of surrounding breakpoint regions involved in the formation of FTKs often revealed homology to Alu (Chen et al, 1989;Chou and Morrison, 1993;Rudiger et al, 1995;Ford et al, 1998;Jeffs et al, 1998;Blanco et al, 2001).…”

Section: Aberrant Repair Of Dsbs Leading To Chromosomal Translocationsmentioning

confidence: 99%