Non-Targeted Secondary Metabolite Profile Study for Deciphering the Cosmeceutical Potential of Red Marine Macro Alga Jania rubens—An LCMS-Based Approach

Dixit, Dhara; Reddy, C. R. K.

doi:10.3390/cosmetics4040045

Cited by 22 publications

(9 citation statements)

References 69 publications

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“…Phytosterols, including gamma-sitosterol ( Sundarraj et al, 2012 ), campesterol, and stigmasta-5,22-dien-3-ol ( Shahzad et al, 2017 ; Vezza et al, 2020 ), have the potential to trigger the production of anti-inflammatory cytokine, hepatoprotective, hypercholesterolemic, antidiabetic, and anticancer activities. The two most dominant lignans, namely, yangambin ( Monte et al, 2007 ; Bala et al, 2015 ) and sesartemin ( Dixit and Reddy, 2017 ; Ickovski et al, 2020 ), tend to exhibit analgesic, antianaphylactic, antiallergic, antileishmanial, anti-PAF, and anticancer activities and can act as an inhibitor of cytochrome P450-linked oxygenase. Polysaccharide-like mome inositol has been reported with antiallopathic, anticirrhotic, antineuropathic, cholesterolytic, and lipotropic activities ( Das et al, 2014 ).…”

Section: Resultsmentioning

confidence: 99%

Pre-clinical toxicity assessment of Artemisia absinthium extract-loaded polymeric nanoparticles associated with their oral administration

et al. 2023

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Background: This study was designed to quantify the composition of the ethanolic extract of Artemisia absinthium through gas chromatography–mass spectrometry analysis and ensure in vivo safety of A. absinthium extract-loaded polymeric nanoparticles (ANPs) before considering their application as a drug carrier via the oral route.Methods: We synthesized N-isopropylacrylamide, N-vinyl pyrrolidone, and acrylic acid crosslinked polymeric NPs by free-radical polymerization reaction and characterized them by Fourier-transform infrared spectroscopy, transmission electron microscopy, and dynamic light scattering spectroscopy. Different concentrations of extract (50 mg/kg, 300 mg/kg, and 2,000 mg/kg body weight) were encapsulated into the hydrophobic core of polymeric micelles for the assessment of acute oral toxicity and their LD50 cut-off value as per the test procedure of OECD guideline 423. Orally administered female Wistar rats were observed for general appearance, behavioral changes, and mortality for the first 30 min, 4 h, 24 h, and then, daily once for 14 days.Result: ANPs at the dose of 300 mg/kg body weight were used as an initial dose, and rats showed few short-lived signs of toxicity, with few histological alterations in the kidney and intestine. Based on these observations, the next set of rats were treated at a lower dose of 50 mg/kg and a higher dose of 2,000 mg/kg ANPs. Rats administered with 50 mg/kg ANPs remained normal throughout the study with insignificant histological disintegration; however, rats treated at 2,000 mg/kg ANPs showed some signs of toxicity followed by mortality among all three rats within 24–36 h, affecting the intestine, liver, and kidney. There were no significant differences in hematological and biochemical parameters among rats treated at 50 mg/kg and 300 mg/kg ANPs.Conclusion: We conclude that the LD50 cut-off value of these ANPs will be 500 mg/kg extract loaded in polymeric NPs.

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Section: Resultsmentioning

confidence: 99%

Pre-clinical toxicity assessment of Artemisia absinthium extract-loaded polymeric nanoparticles associated with their oral administration

et al. 2023

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“…The analytical platforms being routinely used in metabolomics studies includes GC/MS, LC/MS, and NMR spectroscopy. It may be noted that 20 metabolites were reported from Sargassum wightii, 25 23 from Jania rubens, 26 16 from Dictyota dichotoma, 27 and 13 from G. dura; 24 175 metabolites were reported from four brown, five red, and two green algae species. 17 Nevertheless, compared to terrestrial plants, the database for seaweed metabolite is rudimentary and represented by only 1110 metabolites (SWMD; http://www.swmd.co.in/, 2021).…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Profiling of Peak Intensity and Standard Deviation of Metabolites in Industrially Important Red Seaweed Gracilaria dura (Rhodophyta) by ¹H NMR Spectra for Benchmarking

Jaiswar

Thakur

Dawange

et al. 2021

ACS Food Sci. Technol.

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Mapping of regulatory components of cellular functioning by 1H NMR metabolomics has recently paved the way to study biochemical pathways in plants. Despite the enormous complexity and heterogeneity of the metabolites, the estimation of molar concentration allows for their direct quantification without calibration for individual compounds. 1H NMR spectra of near-native extracts were recorded for a large number (55 each) of wild and cultured samples of the industrially important red seaweed Gracilaria dura to obtain quantitative data of all the metabolites. Average and standard deviation of the respective classes were calculated from 1H NMR spectra wherein significant differences between wild and cultured groups were observed in the 1.56–3.50 ppm region. A significant region in the wild samples having a low average (0–0.98) and standard deviation (0.2–0.81) was 1.56–2.96 ppm representing nitrogen-containing compounds. The same region was found to have a much higher standard deviation (0.13–1.73) with average (0–2.03) in cultured samples. In comparison, sugar metabolites (triethanolamine, galactose, lactate, threonine) have a high average peak intensity and similar standard deviation across both groups of samples. This observation reveals that sugar compounds are critical in central metabolic pathways while nitrogen compounds change due to the environment. PCA analysis revealed an interpretable overview of main information enclosed in a multidimensional data set; the differences were correlated to environmental determinants, developmental, and growth states. A signature metabolite profile is presented with minor standard deviation differences between significant parts of the 1H NMR spectra, confirming its use as a rapid chemo-taxonomic tool supplementary to the conventional approach.

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“…Malonylshisonin and 4′-demalonylsalvianin, two of the anthocyanins that fall under flavonoids, are found in Jania rubens extract. Anthocyanins may provide UV radiation protection, slow down skin aging, and stop inflammation and lipid peroxidation [79]. Figure 3 illustrates the peptide extraction technologies for red algae and their dermal application, as reported in recent studies.…”

Section: Anti-aging Activitymentioning

confidence: 97%

Development of Bioactive Peptides Derived from Red Algae for Dermal Care Applications: Recent Advances

et al. 2023

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Bioactive peptides produced from proteinaceous red algae biomass with varied structures have garnered much attention in biological applications and production. Unfortunately, there have been few studies on developing approaches to feasible bioactive peptide production and purification. Our goal with this article is to explore the latest trends in easily applicable approaches for extracting bioactive peptides for cutaneous applications. Bibliometric statistics show that the number of scientific publications is growing, with Asia ranking as the highest producer. Peptide purity and bioactivity are the most important factors to consider while extracting and identifying peptides using various separation techniques. To generate novel bioactive peptides with high yield and low cost, future research should focus on increasing the yields and improving the separation methods. Moreover, human clinical trials should be conducted to validate their potential health benefits. Thus, the final objective of this literature review was to give an insight into the bioactive properties of red algae-derived peptides, which have proven potential for dermal application with anti-melanogenic, collagenogenic, antioxidant, antiaging, and photoprotective activities, etc. Moreover, it covers the algal peptides’ scope for use in nutraceuticals and pharmaceuticals, and future studies for their emerging applications.

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Non-Targeted Secondary Metabolite Profile Study for Deciphering the Cosmeceutical Potential of Red Marine Macro Alga Jania rubens—An LCMS-Based Approach

Cited by 22 publications

References 69 publications

Pre-clinical toxicity assessment of Artemisia absinthium extract-loaded polymeric nanoparticles associated with their oral administration

Pre-clinical toxicity assessment of Artemisia absinthium extract-loaded polymeric nanoparticles associated with their oral administration

Profiling of Peak Intensity and Standard Deviation of Metabolites in Industrially Important Red Seaweed Gracilaria dura (Rhodophyta) by ¹H NMR Spectra for Benchmarking

Development of Bioactive Peptides Derived from Red Algae for Dermal Care Applications: Recent Advances

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Non-Targeted Secondary Metabolite Profile Study for Deciphering the Cosmeceutical Potential of Red Marine Macro Alga Jania rubens—An LCMS-Based Approach

Cited by 22 publications

References 69 publications

Pre-clinical toxicity assessment of Artemisia absinthium extract-loaded polymeric nanoparticles associated with their oral administration

Pre-clinical toxicity assessment of Artemisia absinthium extract-loaded polymeric nanoparticles associated with their oral administration

Profiling of Peak Intensity and Standard Deviation of Metabolites in Industrially Important Red Seaweed Gracilaria dura (Rhodophyta) by 1H NMR Spectra for Benchmarking

Development of Bioactive Peptides Derived from Red Algae for Dermal Care Applications: Recent Advances

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Profiling of Peak Intensity and Standard Deviation of Metabolites in Industrially Important Red Seaweed Gracilaria dura (Rhodophyta) by ¹H NMR Spectra for Benchmarking