Non-targeted metabolite profiling in activated macrophage secretion

Sugimoto, Masahiro; Sakagami, Hiroshi; Yokote, Yoshiko; Onuma, Hiromi; Kaneko, Miku; Mori, Masayo; Sakaguchi, Yasuko; Soga, Tomoyoshi; Tomita, Masaru

doi:10.1007/s11306-011-0353-9

Cited by 84 publications

(79 citation statements)

References 33 publications

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“…At present, the ability of activated macrophages to secrete itaconic acid has been reported (90,91). In line with this finding, itaconic acid has been found to be more abundant in the serum of pregnant women who subsequently developed diabetes when compared to controls with uncomplicated pregnancies.…”

Section: Itaconic Acid Secretion and Metabolism In Mammalian Cellsmentioning

confidence: 66%

“…(93). In 2011, Sugimoto et al (91) discovered that mammalian immune cells are also able to synthesize itaconic acid (see Section 5).…”

Section: The Beginning Of Itaconic Acid Productionmentioning

confidence: 99%

“…However, industrial companies are still interested in optimizing the production process to satisfy the increasing demand for itaconic acid for widespread applications (47,72). In a recent surprising discovery, itaconic acid biosynthesis was found in mammalian immune cells and has been linked to inflammation (91). Immune cells, such as macrophages and dendritic cells, are known to undergo a drastic metabolic change during inflammatory processes.…”

Section: Introductionmentioning

confidence: 99%

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Itaconic Acid: The Surprising Role of an Industrial Compound as a Mammalian Antimicrobial Metabolite

2015

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Itaconic acid is well known as a precursor for polymer synthesis and has been involved in industrial processes for decades. In a recent surprising discovery, itaconic acid was found to play a role as an immune-supportive metabolite in mammalian immune cells, where it is synthesized as an antimicrobial compound from the citric acid cycle intermediate cis-aconitic acid. Although the immune-responsive gene 1 protein (IRG1) has been associated to immune response without a mechanistic function, the critical link to itaconic acid production through an enzymatic function of this protein was only recently revealed. In this review, we highlight the history of itaconic acid as an industrial and antimicrobial compound, starting with its biotechnological synthesis and ending with its antimicrobial function in mammalian immune cells. 12.1

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Section: Itaconic Acid Secretion and Metabolism In Mammalian Cellsmentioning

confidence: 66%

“…(93). In 2011, Sugimoto et al (91) discovered that mammalian immune cells are also able to synthesize itaconic acid (see Section 5).…”

Section: The Beginning Of Itaconic Acid Productionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Itaconic Acid: The Surprising Role of an Industrial Compound as a Mammalian Antimicrobial Metabolite

2015

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“…For over fifteen years, Irg1 was scarcely researched and had no well-defined function. Then in 2011, three groups described mammalian itaconate production in three separate immune-related contexts – in the lungs of Mycobacterium tuberculosis (MTB) infected mice (Shin et al, 2011), in supernatant of LPS-treated macrophage-like RAW264.7 cells (Sugimoto et al, 2011), and in the intracellular compartment of glia-like VM-M3 cells (Strelko et al, 2011). These findings laid the groundwork for a unifying study by Michelucci et al, which showed that murine and human Irg1 are sufficient to induce itaconate production and that they are necessary for LPS-induced itaconate production (Michelucci et al, 2013).…”

Section: A Second Life For Itaconatementioning

confidence: 99%

Food Fight: Role of Itaconate and Other Metabolites in Antimicrobial Defense

2016

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“…Trans-Aconitate is generated from cis-aconitate by acytosolic aconitate-∆-isomerase (Adi1) that belongs to the PrpF family of [75]. Sugimoto et al [85] discovered that mammalian immune cells are able to synthesize IA.…”

Section: Introductionmentioning

confidence: 99%

Emerging biotechnologies for production of itaconic acid and its applications as a platform chemical

Saha¹

2017

Journal of Industrial Microbiology and Biotechnology

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Recently, itaconic acid (IA), an unsaturated C5-dicarboxylic acid, has attracted much attention as a biobased building block chemical. It is produced industrially (>80 g L) from glucose by fermentation with Aspergillus terreus. The titer is low compared with citric acid production (>200 g L). This review summarizes the latest progress on enhancing the yield and productivity of IA production. IA biosynthesis involves the decarboxylation of the TCA cycle intermediate cis-aconitate through the action of cis-aconitate decarboxylase (CAD) enzyme encoded by the CadA gene in A. terreus. A number of recombinant microorganisms have been developed in an effort to overproduce it. IA is used as a monomer for production of superabsorbent polymer, resins, plastics, paints, and synthetic fibers. Its applications as a platform chemical are highlighted. It has a strong potential to replace petroleum-based methylacrylic acid in industry which will create a huge market for IA.

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Non-targeted metabolite profiling in activated macrophage secretion

Cited by 84 publications

References 33 publications

Itaconic Acid: The Surprising Role of an Industrial Compound as a Mammalian Antimicrobial Metabolite

Itaconic Acid: The Surprising Role of an Industrial Compound as a Mammalian Antimicrobial Metabolite

Food Fight: Role of Itaconate and Other Metabolites in Antimicrobial Defense

Emerging biotechnologies for production of itaconic acid and its applications as a platform chemical

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