Non-systemic vasculitic neuropathy

Collins, Michael; Periquet, Magali

doi:10.1097/00019052-200410000-00009

Cited by 65 publications

(42 citation statements)

References 83 publications

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“…Therefore, increased protein levels can be used as a supportive but not mandatory criterion for the diagnosis 13 . Increased CSF protein without pleocytosis is usually present in patients with peripheral neuropathy associated with chronic GHVD 6,15 . Of the published CSF analyses, there was no evidence of blood-brain barrier disruption with increased CFS protein from chronic myeloid leukemia patients studied during HSCT and chronic GVHD, but there is report of increased CSF protein secondary to CIDP after HSCT (Table 2) 6,7,10, 11,16 .…”

Section: Discussionmentioning

confidence: 99%

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Chronic inflammatory demyelinating polyradiculoneuropathy in chronic graft-versus-host disease following allogeneic hematopoietic stem cell transplantation: case report

Lorenzoni

Scola

Moreira

et al. 2007

Arq. Neuro-Psiquiatr.

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-The chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is an unusual but important complication of hematopoietic stem cell transplantation (HSCT) rarely reported to date. We describe a 17-year-old woman with a diagnosis of acute myeloid leukemia due to Fanconi's anemia who was submitted to allogeneic HSCT and developed CIDP as part of graft-versus-host disease. Investigation showed high cerebrospinal fluid protein; electrophysiological studies revealed sensory-motor demyelinating polyradiculoneuropathy; muscle and nerve biopsy were compatible with CIDP.KEY WORDS: graft-versus-host disease, hematopoietic stem cell transplant, bone marrow transplantation, neuropathy, polyneuropathy.polirradiculoneuropatia desmielinizante inflamatória crônica na doença do enxerto contra o hospedeiro após transplante de células hematopoiéticas alogênicas: relato de caso RESUMO -A polirradiculoneuropatia desmielinizante inflamatória crônica (CIDP) é uma incomum, porém, importante complicação do transplante de células hematopoiéticas (HSCT) raramente relatada até a data. Nós descrevemos uma mulher de 17 anos com diagnóstico de leucemia mielóide aguda por anemia de Fanconi que foi submetida à HSCT e desenvolveu CIDP como parte da doença do enxerto contra o hospedeiro. A investigação mostrou elevação na proteína no líquor; estudo eletrofisiológico revelando polirradiculoneuropatia desmielinizante sensitivo-motora; e biópsia de músculo e nervo compatível com CIDP. PALAVRAS-CHAVE: doença do enxerto contra o hospedeiro, transplante de células hematopoiéticas, transplante de medula óssea, neuropatia, polineuropatia.

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Section: Discussionmentioning

confidence: 99%

“…The nerve ischemia secondary to inflammatory processes could induce acute axonal asymmetrical degeneration within the fascicle, that can occurs in CIDP, but had not been described to date in CIDP by chronic GVHD after HSCT 15,18 .…”

mentioning

confidence: 99%

Chronic inflammatory demyelinating polyradiculoneuropathy in chronic graft-versus-host disease following allogeneic hematopoietic stem cell transplantation: case report

Lorenzoni

Scola

Moreira

et al. 2007

Arq. Neuro-Psiquiatr.

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“…Damage to the blood-nerve-barrier is induced by pro-inflammatory cytokines, oxidative stress-derived molecules, or metallo-proteinases [7]. Altered expression and function of adhesion molecules or leukocytes (primary T-cell) and endothelial cell activation play a key role in the pathogenesis [8,9].…”

Section: Discussionmentioning

confidence: 99%

An Unusual Case of Henoch Schönlein Purpura Presenting as Mononeuritis Multiplex

Goyal¹,

Mohan²,

Sehgal³

2016

Arc Cas Rep CMed

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IgA vasculitis [Henoch Schönlein Purpura (HSP)] is characterized by leukocytoclastic vasculitis involving the small vessels with deposition of immune complexes that contain IgA. Clinical signs include purpura, arthralgia, glomerulonephritis and gastrointestinal involvement. HSP with nervous system involvement is very uncommon. We report a 12 year old boy with IgA vasculitis who presented with typical rash and Mononeuritis Multiplex and responded well to steroid therapy. HSP presenting as Mononeuritis Multiplex has rarely been reported in children. Clinicians must know of this rare complication of HSP which, when present, may be well managed with steroids.

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“…Most patients present with subacute onset, which progresses with a painful, multifocal, asymmetric, and predominantly distal weakness [4]. Although NSVN appears to have a better prognosis than systemic vasculitides after treatment, more than 30% of patients relapse, and 60% have residual pain [5].…”

Section: Introductionmentioning

confidence: 99%

Gait Disturbance due to Foot Drop Is Refractory to Treatment in Nonsystemic Vasculitic Neuropathy

et al. 2014

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Background: Nonsystemic vasculitic neuropathy (NSVN) is a vasculitis syndrome clinically restricted to the peripheral nervous system. Although treatment may improve prognosis, daily activities of such patients after treatment have not been well studied. Methods: We evaluated clinical features, laboratory data, nerve conduction, and sural nerve biopsy findings for 16 unbiased consecutive patients with NSVN. Results: Initial symptoms included neuropathic pain (31%) and lower limb sensory disturbance (19%). The mean duration between disease onset and initial treatment was 4.1 ± 4.8 months. Mean modified Rankin scale scores were 3.13 at hospital admission and 2.69 at final follow-up. The poor outcome group had significantly decreased compound muscle action potentials of peroneal nerves and significantly more patients presenting with foot drop compared with the good outcome group. No other significant differences were found. Conclusion: Pretreatment foot drop signaled poor outcome in daily activities of patients with NSVN, and earlier treatment may be critical for these patients.

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Non-systemic vasculitic neuropathy

Cited by 65 publications

References 83 publications

Chronic inflammatory demyelinating polyradiculoneuropathy in chronic graft-versus-host disease following allogeneic hematopoietic stem cell transplantation: case report

Chronic inflammatory demyelinating polyradiculoneuropathy in chronic graft-versus-host disease following allogeneic hematopoietic stem cell transplantation: case report

An Unusual Case of Henoch Schönlein Purpura Presenting as Mononeuritis Multiplex

Gait Disturbance due to Foot Drop Is Refractory to Treatment in Nonsystemic Vasculitic Neuropathy

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